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Protein

Antigen KI-67

Gene

MKI67

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be required for maintaining cell proliferation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3034 – 30418ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Antigen KI-67
Gene namesi
Name:MKI67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:7107. MKI67.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: Ensembl
  • condensed chromosome Source: Ensembl
  • cytoplasm Source: Ensembl
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30825.

Polymorphism and mutation databases

BioMutaiMKI67.
DMDMi118572663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32563256Antigen KI-67PRO_0000084301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei128 – 1281PhosphoserineCombined sources
Modified residuei264 – 2641PhosphoserineCombined sources
Modified residuei308 – 3081PhosphoserineCombined sources
Modified residuei328 – 3281PhosphothreonineCombined sources
Modified residuei347 – 3471PhosphothreonineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei357 – 3571PhosphoserineCombined sources
Modified residuei401 – 4011PhosphothreonineCombined sources
Modified residuei411 – 4111PhosphoserineCombined sources
Modified residuei538 – 5381PhosphoserineCombined sources
Modified residuei543 – 5431PhosphothreonineCombined sources
Modified residuei579 – 5791PhosphoserineCombined sources
Modified residuei584 – 5841PhosphoserineCombined sources
Modified residuei648 – 6481PhosphoserineCombined sources
Modified residuei761 – 7611PhosphothreonineCombined sources
Modified residuei859 – 8591PhosphoserineCombined sources
Modified residuei1017 – 10171PhosphothreonineCombined sources
Cross-linki1035 – 1035Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1071 – 10711PhosphoserineCombined sources
Modified residuei1091 – 10911PhosphothreonineCombined sources
Cross-linki1093 – 1093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei1098 – 10981PhosphoserineCombined sources
Modified residuei1111 – 11111PhosphothreonineCombined sources
Modified residuei1131 – 11311PhosphoserineCombined sources
Modified residuei1139 – 11391PhosphothreonineCombined sources
Modified residuei1142 – 11421PhosphoserineCombined sources
Modified residuei1167 – 11671PhosphothreonineCombined sources
Modified residuei1176 – 11761PhosphothreonineCombined sources
Modified residuei1193 – 11931PhosphothreonineCombined sources
Modified residuei1207 – 12071PhosphoserineCombined sources
Modified residuei1233 – 12331PhosphothreonineCombined sources
Modified residuei1253 – 12531PhosphoserineCombined sources
Modified residuei1256 – 12561PhosphoserineCombined sources
Modified residuei1261 – 12611PhosphothreonineCombined sources
Modified residuei1298 – 12981PhosphothreonineCombined sources
Modified residuei1315 – 13151PhosphothreonineCombined sources
Modified residuei1327 – 13271PhosphothreonineCombined sources
Modified residuei1329 – 13291PhosphoserineCombined sources
Modified residuei1335 – 13351PhosphothreonineCombined sources
Modified residuei1355 – 13551PhosphothreonineCombined sources
Modified residuei1376 – 13761PhosphoserineCombined sources
Modified residuei1383 – 13831PhosphothreonineCombined sources
Modified residuei1496 – 14961PhosphoserineCombined sources
Modified residuei1503 – 15031PhosphothreonineCombined sources
Modified residuei1506 – 15061PhosphoserineCombined sources
Modified residuei1540 – 15401PhosphothreonineCombined sources
Modified residuei1552 – 15521PhosphotyrosineCombined sources
Modified residuei1557 – 15571PhosphothreonineCombined sources
Modified residuei1569 – 15691PhosphothreonineCombined sources
Modified residuei1571 – 15711PhosphoserineCombined sources
Modified residuei1639 – 16391N6-acetyllysineCombined sources
Cross-linki1643 – 1643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1679 – 16791PhosphoserineCombined sources
Modified residuei1689 – 16891PhosphoserineCombined sources
Modified residuei1719 – 17191PhosphothreonineCombined sources
Modified residuei1721 – 17211PhosphoserineCombined sources
Modified residuei1740 – 17401PhosphoserineCombined sources
Modified residuei1747 – 17471PhosphothreonineCombined sources
Modified residuei1764 – 17641PhosphothreonineCombined sources
Modified residuei1784 – 17841PhosphothreonineCombined sources
Modified residuei1801 – 18011PhosphothreonineCombined sources
Modified residuei1815 – 18151PhosphoserineCombined sources
Modified residuei1841 – 18411PhosphothreonineCombined sources
Modified residuei1861 – 18611PhosphoserineCombined sources
Modified residuei1864 – 18641PhosphoserineCombined sources
Modified residuei1869 – 18691PhosphothreonineCombined sources
Modified residuei1897 – 18971PhosphothreonineCombined sources
Modified residuei1923 – 19231PhosphothreonineCombined sources
Modified residuei1937 – 19371PhosphoserineCombined sources
Modified residuei1963 – 19631PhosphothreonineCombined sources
Modified residuei1983 – 19831PhosphoserineCombined sources
Modified residuei2005 – 20051N6-acetyllysineCombined sources
Cross-linki2009 – 2009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki2009 – 2009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2065 – 20651PhosphothreonineCombined sources
Cross-linki2067 – 2067Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei2072 – 20721PhosphoserineCombined sources
Modified residuei2085 – 20851PhosphothreonineCombined sources
Modified residuei2105 – 21051PhosphoserineCombined sources
Modified residuei2113 – 21131PhosphothreonineCombined sources
Modified residuei2135 – 21351PhosphoserineCombined sources
Modified residuei2203 – 22031PhosphothreonineCombined sources
Modified residuei2223 – 22231PhosphoserineCombined sources
Modified residuei2231 – 22311PhosphothreonineCombined sources
Modified residuei2233 – 22331PhosphothreonineCombined sources
Modified residuei2239 – 22391PhosphoserineCombined sources
Modified residuei2268 – 22681PhosphothreonineCombined sources
Modified residuei2285 – 22851PhosphothreonineCombined sources
Modified residuei2325 – 23251PhosphothreonineCombined sources
Modified residuei2328 – 23281PhosphothreonineCombined sources
Modified residuei2333 – 23331PhosphothreonineCombined sources
Modified residuei2344 – 23441PhosphoserineCombined sources
Modified residuei2352 – 23521PhosphothreonineCombined sources
Modified residuei2389 – 23891PhosphothreonineCombined sources
Modified residuei2395 – 23951PhosphoserineCombined sources
Modified residuei2406 – 24061PhosphothreonineCombined sources
Modified residuei2420 – 24201PhosphoserineCombined sources
Modified residuei2426 – 24261PhosphothreonineCombined sources
Modified residuei2446 – 24461PhosphothreonineCombined sources
Modified residuei2466 – 24661PhosphoserineCombined sources
Cross-linki2492 – 2492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei2505 – 25051PhosphoserineCombined sources
Modified residuei2528 – 25281PhosphoserineCombined sources
Modified residuei2588 – 25881PhosphoserineCombined sources
Cross-linki2613 – 2613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki2613 – 2613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2638 – 26381PhosphoserineCombined sources
Modified residuei2708 – 27081PhosphoserineCombined sources
Cross-linki2734 – 2734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki2734 – 2734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2827 – 28271PhosphoserineCombined sources
Modified residuei2828 – 28281PhosphoserineCombined sources
Cross-linki2852 – 2852Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki2852 – 2852Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei3041 – 30411PhosphoserineCombined sources
Modified residuei3128 – 31281PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP46013.
MaxQBiP46013.
PaxDbiP46013.
PeptideAtlasiP46013.
PRIDEiP46013.

PTM databases

iPTMnetiP46013.
PhosphoSiteiP46013.
SwissPalmiP46013.

Expressioni

Developmental stagei

Expression of this antigen occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected.

Gene expression databases

BgeeiENSG00000148773.
CleanExiHS_MKI67.
ExpressionAtlasiP46013. baseline and differential.
GenevisibleiP46013. HS.

Organism-specific databases

HPAiCAB000058.
CAB068198.
HPA000451.
HPA001164.

Interactioni

Subunit structurei

Interacts with KIF15. Binds through the FHA domain to NIFK. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.6 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110434. 53 interactions.
DIPiDIP-28132N.
IntActiP46013. 34 interactions.
MINTiMINT-137995.
STRINGi9606.ENSP00000357643.

Structurei

Secondary structure

1
3256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 128Combined sources
Beta strandi15 – 217Combined sources
Beta strandi24 – 329Combined sources
Beta strandi35 – 384Combined sources
Beta strandi49 – 535Combined sources
Beta strandi58 – 603Combined sources
Beta strandi65 – 673Combined sources
Beta strandi80 – 823Combined sources
Beta strandi86 – 894Combined sources
Beta strandi94 – 996Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R21NMR-A1-120[»]
2AFFNMR-A1-120[»]
ProteinModelPortaliP46013.
SMRiP46013. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7650FHAPROSITE-ProRule annotationAdd
BLAST
Repeati1000 – 11121131Add
BLAST
Repeati1122 – 12341132Add
BLAST
Repeati1244 – 13561133Add
BLAST
Repeati1366 – 14771124Add
BLAST
Repeati1487 – 15981125Add
BLAST
Repeati1608 – 17201136Add
BLAST
Repeati1730 – 18421137Add
BLAST
Repeati1851 – 19641148Add
BLAST
Repeati1974 – 20861139Add
BLAST
Repeati2096 – 220410910Add
BLAST
Repeati2214 – 232611311Add
BLAST
Repeati2335 – 244711312Add
BLAST
Repeati2457 – 256911313Add
BLAST
Repeati2579 – 268911114Add
BLAST
Repeati2699 – 280811015Add
BLAST
Repeati2818 – 292811116Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1000 – 2928192916 X 122 AA approximate repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JR7C. Eukaryota.
ENOG410ZXYW. LUCA.
GeneTreeiENSGT00530000064425.
HOGENOMiHOG000113223.
HOVERGENiHBG006213.
InParanoidiP46013.
KOiK17582.
OMAiQTPKEKA.
OrthoDBiEOG091G005S.
PhylomeDBiP46013.
TreeFamiTF336000.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08065. K167R. 16 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM01295. K167R. 16 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P46013-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPTRRLVTI KRSGVDGPHF PLSLSTCLFG RGIECDIRIQ LPVVSKQHCK
60 70 80 90 100
IEIHEQEAIL HNFSSTNPTQ VNGSVIDEPV RLKHGDVITI IDRSFRYENE
110 120 130 140 150
SLQNGRKSTE FPRKIREQEP ARRVSRSSFS SDPDEKAQDS KAYSKITEGK
160 170 180 190 200
VSGNPQVHIK NVKEDSTADD SKDSVAQGTT NVHSSEHAGR NGRNAADPIS
210 220 230 240 250
GDFKEISSVK LVSRYGELKS VPTTQCLDNS KKNESPFWKL YESVKKELDV
260 270 280 290 300
KSQKENVLQY CRKSGLQTDY ATEKESADGL QGETQLLVSR KSRPKSGGSG
310 320 330 340 350
HAVAEPASPE QELDQNKGKG RDVESVQTPS KAVGASFPLY EPAKMKTPVQ
360 370 380 390 400
YSQQQNSPQK HKNKDLYTTG RRESVNLGKS EGFKAGDKTL TPRKLSTRNR
410 420 430 440 450
TPAKVEDAAD SATKPENLSS KTRGSIPTDV EVLPTETEIH NEPFLTLWLT
460 470 480 490 500
QVERKIQKDS LSKPEKLGTT AGQMCSGLPG LSSVDINNFG DSINESEGIP
510 520 530 540 550
LKRRRVSFGG HLRPELFDEN LPPNTPLKRG EAPTKRKSLV MHTPPVLKKI
560 570 580 590 600
IKEQPQPSGK QESGSEIHVE VKAQSLVISP PAPSPRKTPV ASDQRRRSCK
610 620 630 640 650
TAPASSSKSQ TEVPKRGGRK SGNLPSKRVS ISRSQHDILQ MICSKRRSGA
660 670 680 690 700
SEANLIVAKS WADVVKLGAK QTQTKVIKHG PQRSMNKRQR RPATPKKPVG
710 720 730 740 750
EVHSQFSTGH ANSPCTIIIG KAHTEKVHVP ARPYRVLNNF ISNQKMDFKE
760 770 780 790 800
DLSGIAEMFK TPVKEQPQLT STCHIAISNS ENLLGKQFQG TDSGEEPLLP
810 820 830 840 850
TSESFGGNVF FSAQNAAKQP SDKCSASPPL RRQCIRENGN VAKTPRNTYK
860 870 880 890 900
MTSLETKTSD TETEPSKTVS TANRSGRSTE FRNIQKLPVE SKSEETNTEI
910 920 930 940 950
VECILKRGQK ATLLQQRREG EMKEIERPFE TYKENIELKE NDEKMKAMKR
960 970 980 990 1000
SRTWGQKCAP MSDLTDLKSL PDTELMKDTA RGQNLLQTQD HAKAPKSEKG
1010 1020 1030 1040 1050
KITKMPCQSL QPEPINTPTH TKQQLKASLG KVGVKEELLA VGKFTRTSGE
1060 1070 1080 1090 1100
TTHTHREPAG DGKSIRTFKE SPKQILDPAA RVTGMKKWPR TPKEEAQSLE
1110 1120 1130 1140 1150
DLAGFKELFQ TPGPSEESMT DEKTTKIACK SPPPESVDTP TSTKQWPKRS
1160 1170 1180 1190 1200
LRKADVEEEF LALRKLTPSA GKAMLTPKPA GGDEKDIKAF MGTPVQKLDL
1210 1220 1230 1240 1250
AGTLPGSKRQ LQTPKEKAQA LEDLAGFKEL FQTPGHTEEL VAAGKTTKIP
1260 1270 1280 1290 1300
CDSPQSDPVD TPTSTKQRPK RSIRKADVEG ELLACRNLMP SAGKAMHTPK
1310 1320 1330 1340 1350
PSVGEEKDII IFVGTPVQKL DLTENLTGSK RRPQTPKEEA QALEDLTGFK
1360 1370 1380 1390 1400
ELFQTPGHTE EAVAAGKTTK MPCESSPPES ADTPTSTRRQ PKTPLEKRDV
1410 1420 1430 1440 1450
QKELSALKKL TQTSGETTHT DKVPGGEDKS INAFRETAKQ KLDPAASVTG
1460 1470 1480 1490 1500
SKRHPKTKEK AQPLEDLAGL KELFQTPVCT DKPTTHEKTT KIACRSQPDP
1510 1520 1530 1540 1550
VDTPTSSKPQ SKRSLRKVDV EEEFFALRKR TPSAGKAMHT PKPAVSGEKN
1560 1570 1580 1590 1600
IYAFMGTPVQ KLDLTENLTG SKRRLQTPKE KAQALEDLAG FKELFQTRGH
1610 1620 1630 1640 1650
TEESMTNDKT AKVACKSSQP DPDKNPASSK RRLKTSLGKV GVKEELLAVG
1660 1670 1680 1690 1700
KLTQTSGETT HTHTEPTGDG KSMKAFMESP KQILDSAASL TGSKRQLRTP
1710 1720 1730 1740 1750
KGKSEVPEDL AGFIELFQTP SHTKESMTNE KTTKVSYRAS QPDLVDTPTS
1760 1770 1780 1790 1800
SKPQPKRSLR KADTEEEFLA FRKQTPSAGK AMHTPKPAVG EEKDINTFLG
1810 1820 1830 1840 1850
TPVQKLDQPG NLPGSNRRLQ TRKEKAQALE ELTGFRELFQ TPCTDNPTTD
1860 1870 1880 1890 1900
EKTTKKILCK SPQSDPADTP TNTKQRPKRS LKKADVEEEF LAFRKLTPSA
1910 1920 1930 1940 1950
GKAMHTPKAA VGEEKDINTF VGTPVEKLDL LGNLPGSKRR PQTPKEKAKA
1960 1970 1980 1990 2000
LEDLAGFKEL FQTPGHTEES MTDDKITEVS CKSPQPDPVK TPTSSKQRLK
2010 2020 2030 2040 2050
ISLGKVGVKE EVLPVGKLTQ TSGKTTQTHR ETAGDGKSIK AFKESAKQML
2060 2070 2080 2090 2100
DPANYGTGME RWPRTPKEEA QSLEDLAGFK ELFQTPDHTE ESTTDDKTTK
2110 2120 2130 2140 2150
IACKSPPPES MDTPTSTRRR PKTPLGKRDI VEELSALKQL TQTTHTDKVP
2160 2170 2180 2190 2200
GDEDKGINVF RETAKQKLDP AASVTGSKRQ PRTPKGKAQP LEDLAGLKEL
2210 2220 2230 2240 2250
FQTPICTDKP TTHEKTTKIA CRSPQPDPVG TPTIFKPQSK RSLRKADVEE
2260 2270 2280 2290 2300
ESLALRKRTP SVGKAMDTPK PAGGDEKDMK AFMGTPVQKL DLPGNLPGSK
2310 2320 2330 2340 2350
RWPQTPKEKA QALEDLAGFK ELFQTPGTDK PTTDEKTTKI ACKSPQPDPV
2360 2370 2380 2390 2400
DTPASTKQRP KRNLRKADVE EEFLALRKRT PSAGKAMDTP KPAVSDEKNI
2410 2420 2430 2440 2450
NTFVETPVQK LDLLGNLPGS KRQPQTPKEK AEALEDLVGF KELFQTPGHT
2460 2470 2480 2490 2500
EESMTDDKIT EVSCKSPQPE SFKTSRSSKQ RLKIPLVKVD MKEEPLAVSK
2510 2520 2530 2540 2550
LTRTSGETTQ THTEPTGDSK SIKAFKESPK QILDPAASVT GSRRQLRTRK
2560 2570 2580 2590 2600
EKARALEDLV DFKELFSAPG HTEESMTIDK NTKIPCKSPP PELTDTATST
2610 2620 2630 2640 2650
KRCPKTRPRK EVKEELSAVE RLTQTSGQST HTHKEPASGD EGIKVLKQRA
2660 2670 2680 2690 2700
KKKPNPVEEE PSRRRPRAPK EKAQPLEDLA GFTELSETSG HTQESLTAGK
2710 2720 2730 2740 2750
ATKIPCESPP LEVVDTTAST KRHLRTRVQK VQVKEEPSAV KFTQTSGETT
2760 2770 2780 2790 2800
DADKEPAGED KGIKALKESA KQTPAPAASV TGSRRRPRAP RESAQAIEDL
2810 2820 2830 2840 2850
AGFKDPAAGH TEESMTDDKT TKIPCKSSPE LEDTATSSKR RPRTRAQKVE
2860 2870 2880 2890 2900
VKEELLAVGK LTQTSGETTH TDKEPVGEGK GTKAFKQPAK RKLDAEDVIG
2910 2920 2930 2940 2950
SRRQPRAPKE KAQPLEDLAS FQELSQTPGH TEELANGAAD SFTSAPKQTP
2960 2970 2980 2990 3000
DSGKPLKISR RVLRAPKVEP VGDVVSTRDP VKSQSKSNTS LPPLPFKRGG
3010 3020 3030 3040 3050
GKDGSVTGTK RLRCMPAPEE IVEELPASKK QRVAPRARGK SSEPVVIMKR
3060 3070 3080 3090 3100
SLRTSAKRIE PAEELNSNDM KTNKEEHKLQ DSVPENKGIS LRSRRQNKTE
3110 3120 3130 3140 3150
AEQQITEVFV LAERIEINRN EKKPMKTSPE MDIQNPDDGA RKPIPRDKVT
3160 3170 3180 3190 3200
ENKRCLRSAR QNESSQPKVA EESGGQKSAK VLMQNQKGKG EAGNSDSMCL
3210 3220 3230 3240 3250
RSRKTKSQPA ASTLESKSVQ RVTRSVKRCA ENPKKAEDNV CVKKIRTRSH

RDSEDI
Length:3,256
Mass (Da):358,694
Last modified:November 28, 2006 - v2
Checksum:i1332BC6C799AD64D
GO
Isoform Short (identifier: P46013-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-495: Missing.

Show »
Length:2,896
Mass (Da):319,444
Checksum:i4FACAA90AC686C72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti619 – 6268RKSGNLPS → ERVATCLQ in CAA46519 (PubMed:8227122).Curated
Sequence conflicti619 – 6268RKSGNLPS → ERVATCLQ in CAA46520 (PubMed:8227122).Curated
Sequence conflicti2205 – 22051I → V in CAA46519 (PubMed:8227122).Curated
Sequence conflicti2205 – 22051I → V in CAA46520 (PubMed:8227122).Curated
Sequence conflicti2892 – 28932KL → NV in CAA46519 (PubMed:8227122).Curated
Sequence conflicti2892 – 28932KL → NV in CAA46520 (PubMed:8227122).Curated
Sequence conflicti3246 – 32461R → T in CAA46519 (PubMed:8227122).Curated
Sequence conflicti3246 – 32461R → T in CAA46520 (PubMed:8227122).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041N → S.
Corresponds to variant rs2071498 [ dbSNP | Ensembl ].
VAR_029055
Natural varianti238 – 2381W → R.
Corresponds to variant rs7095325 [ dbSNP | Ensembl ].
VAR_029056
Natural varianti497 – 4971E → D.
Corresponds to variant rs11016076 [ dbSNP | Ensembl ].
VAR_029057
Natural varianti574 – 5741Q → P.
Corresponds to variant rs4471342 [ dbSNP | Ensembl ].
VAR_029058
Natural varianti631 – 6311I → L.
Corresponds to variant rs997983 [ dbSNP | Ensembl ].
VAR_024161
Natural varianti832 – 8321R → W.
Corresponds to variant rs34916904 [ dbSNP | Ensembl ].
VAR_033995
Natural varianti854 – 8541L → V.
Corresponds to variant rs2240 [ dbSNP | Ensembl ].
VAR_024162
Natural varianti872 – 8721A → V.1 Publication
Corresponds to variant rs2853344 [ dbSNP | Ensembl ].
VAR_029059
Natural varianti1042 – 10421G → S.
Corresponds to variant rs2152143 [ dbSNP | Ensembl ].
VAR_024163
Natural varianti1120 – 11201T → S.
Corresponds to variant rs11016074 [ dbSNP | Ensembl ].
VAR_029060
Natural varianti1247 – 12471T → I.
Corresponds to variant rs4750685 [ dbSNP | Ensembl ].
VAR_021838
Natural varianti1403 – 14031E → V.
Corresponds to variant rs3740423 [ dbSNP | Ensembl ].
VAR_020047
Natural varianti1470 – 14701L → W.1 Publication
Corresponds to variant rs2853345 [ dbSNP | Ensembl ].
VAR_029061
Natural varianti1559 – 15591V → M.
Corresponds to variant rs7918199 [ dbSNP | Ensembl ].
VAR_029062
Natural varianti1622 – 16221P → L.1 Publication
Corresponds to variant rs2782871 [ dbSNP | Ensembl ].
VAR_029063
Natural varianti1849 – 18491T → A.1 Publication
Corresponds to variant rs2782872 [ dbSNP | Ensembl ].
VAR_029064
Natural varianti1876 – 18761R → Q.
Corresponds to variant rs11591817 [ dbSNP | Ensembl ].
VAR_029065
Natural varianti1951 – 19511L → I.
Corresponds to variant rs34116632 [ dbSNP | Ensembl ].
VAR_033996
Natural varianti2101 – 21011I → T.
Corresponds to variant rs11016073 [ dbSNP | Ensembl ].
VAR_029066
Natural varianti2337 – 23371T → N.
Corresponds to variant rs7083622 [ dbSNP | Ensembl ].
VAR_024164
Natural varianti2363 – 23631N → S.
Corresponds to variant rs7071768 [ dbSNP | Ensembl ].
VAR_029067
Natural varianti2607 – 26071R → H.
Corresponds to variant rs34688192 [ dbSNP | Ensembl ].
VAR_061671
Natural varianti2608 – 26081P → L.
Corresponds to variant rs1063535 [ dbSNP | Ensembl ].
VAR_024165
Natural varianti2649 – 26491R → H.
Corresponds to variant rs12777740 [ dbSNP | Ensembl ].
VAR_029068
Natural varianti2720 – 27201T → P.
Corresponds to variant rs1050767 [ dbSNP | Ensembl ].
VAR_024166
Natural varianti2760 – 27601D → G.
Corresponds to variant rs10082391 [ dbSNP | Ensembl ].
VAR_029069
Natural varianti2786 – 27861R → Q.
Corresponds to variant rs10764749 [ dbSNP | Ensembl ].
VAR_029070
Natural varianti2793 – 27931S → N.
Corresponds to variant rs10082533 [ dbSNP | Ensembl ].
VAR_029071
Natural varianti2845 – 28451R → H.
Corresponds to variant rs11016072 [ dbSNP | Ensembl ].
VAR_029072
Natural varianti2868 – 28681T → S.
Corresponds to variant rs2071496 [ dbSNP | Ensembl ].
VAR_024167
Natural varianti2904 – 29041Q → R.
Corresponds to variant rs11016071 [ dbSNP | Ensembl ].
VAR_029073
Natural varianti3097 – 30971N → D.1 Publication
Corresponds to variant rs2798669 [ dbSNP | Ensembl ].
VAR_029074
Natural varianti3102 – 31021E → G.
Corresponds to variant rs34750407 [ dbSNP | Ensembl ].
VAR_033997
Natural varianti3150 – 31501T → S.
Corresponds to variant rs11106 [ dbSNP | Ensembl ].
VAR_014858
Natural varianti3217 – 32171K → E.
Corresponds to variant rs8473 [ dbSNP | Ensembl ].
VAR_014859

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 495360Missing in isoform Short. 1 PublicationVSP_004298Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65550 mRNA. Translation: CAA46519.1.
X65551 mRNA. Translation: CAA46520.1.
AL390236, AL355529 Genomic DNA. Translation: CAH73169.1.
X94762 Genomic DNA. Translation: CAA64388.1.
CCDSiCCDS53588.1. [P46013-2]
CCDS7659.1. [P46013-1]
PIRiA48666.
RefSeqiNP_001139438.1. NM_001145966.1. [P46013-2]
NP_002408.3. NM_002417.4. [P46013-1]
UniGeneiHs.689823.
Hs.80976.

Genome annotation databases

EnsembliENST00000368653; ENSP00000357642; ENSG00000148773. [P46013-2]
ENST00000368654; ENSP00000357643; ENSG00000148773. [P46013-1]
GeneIDi4288.
KEGGihsa:4288.
UCSCiuc001lke.4. human. [P46013-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Ki-67 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65550 mRNA. Translation: CAA46519.1.
X65551 mRNA. Translation: CAA46520.1.
AL390236, AL355529 Genomic DNA. Translation: CAH73169.1.
X94762 Genomic DNA. Translation: CAA64388.1.
CCDSiCCDS53588.1. [P46013-2]
CCDS7659.1. [P46013-1]
PIRiA48666.
RefSeqiNP_001139438.1. NM_001145966.1. [P46013-2]
NP_002408.3. NM_002417.4. [P46013-1]
UniGeneiHs.689823.
Hs.80976.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R21NMR-A1-120[»]
2AFFNMR-A1-120[»]
ProteinModelPortaliP46013.
SMRiP46013. Positions 1-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110434. 53 interactions.
DIPiDIP-28132N.
IntActiP46013. 34 interactions.
MINTiMINT-137995.
STRINGi9606.ENSP00000357643.

PTM databases

iPTMnetiP46013.
PhosphoSiteiP46013.
SwissPalmiP46013.

Polymorphism and mutation databases

BioMutaiMKI67.
DMDMi118572663.

Proteomic databases

EPDiP46013.
MaxQBiP46013.
PaxDbiP46013.
PeptideAtlasiP46013.
PRIDEiP46013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368653; ENSP00000357642; ENSG00000148773. [P46013-2]
ENST00000368654; ENSP00000357643; ENSG00000148773. [P46013-1]
GeneIDi4288.
KEGGihsa:4288.
UCSCiuc001lke.4. human. [P46013-1]

Organism-specific databases

CTDi4288.
GeneCardsiMKI67.
HGNCiHGNC:7107. MKI67.
HPAiCAB000058.
CAB068198.
HPA000451.
HPA001164.
MIMi176741. gene.
neXtProtiNX_P46013.
PharmGKBiPA30825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JR7C. Eukaryota.
ENOG410ZXYW. LUCA.
GeneTreeiENSGT00530000064425.
HOGENOMiHOG000113223.
HOVERGENiHBG006213.
InParanoidiP46013.
KOiK17582.
OMAiQTPKEKA.
OrthoDBiEOG091G005S.
PhylomeDBiP46013.
TreeFamiTF336000.

Miscellaneous databases

ChiTaRSiMKI67. human.
EvolutionaryTraceiP46013.
GeneWikiiKi-67_(protein).
GenomeRNAii4288.
PROiP46013.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148773.
CleanExiHS_MKI67.
ExpressionAtlasiP46013. baseline and differential.
GenevisibleiP46013. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR012568. K167R.
IPR029334. PP1-bd.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
PF08065. K167R. 16 hits.
PF15276. PP1_bind. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
SM01295. K167R. 16 hits.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI67_HUMAN
AccessioniPrimary (citable) accession number: P46013
Secondary accession number(s): Q5VWH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 28, 2006
Last modified: September 7, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.