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P46002 (PTAFR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Platelet-activating factor receptor
Short name=PAF-R
Short name=PAFr
Gene names
Name:Ptafr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

Subunit structure

Interacts with ARRB1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Present in almost all organs including spleen, small intestine, kidney, lung, liver and brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Platelet-activating factor receptor
PRO_0000070096

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3822Helical; Name=1; Potential
Topological domain39 – 5416Cytoplasmic Potential
Transmembrane55 – 7420Helical; Name=2; Potential
Topological domain75 – 9117Extracellular Potential
Transmembrane92 – 11322Helical; Name=3; Potential
Topological domain114 – 13320Cytoplasmic Potential
Transmembrane134 – 15522Helical; Name=4; Potential
Topological domain156 – 18429Extracellular Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 23328Cytoplasmic Potential
Transmembrane234 – 25421Helical; Name=6; Potential
Topological domain255 – 27521Extracellular Potential
Transmembrane276 – 29520Helical; Name=7; Potential
Topological domain296 – 34146Cytoplasmic Potential

Amino acid modifications

Modified residue3091Phosphoserine By similarity
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 173 By similarity

Sequences

Sequence LengthMass (Da)Tools
P46002 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D0AF7290C3D34A5B

FASTA34139,204
        10         20         30         40         50         60 
MEQNGSFRVD SEFRYTLFPI VYSVIFVLGV VANGYVLWVF ATLYPSKKLN EIKIFMVNLT 

        70         80         90        100        110        120 
VADLLFLMTL PLWIVYYSNE GDWIVHKFLC NLAGCLFFIN TYCSVAFLGV ITYNRYQAVA 

       130        140        150        160        170        180 
YPIKTAQATT RKRGITLSLV IWISIAATAS YFLATDSTNV VPKKDGSGNI TRCFEHYEPY 

       190        200        210        220        230        240 
SVPILVVHIF ITSCFFLVFF LIFYCNMVII HTLLTRPVRQ QRKPEVKRRA LWMVCTVLAV 

       250        260        270        280        290        300 
FVICFVPHHV VQLPWTLAEL GYQTNFHQAI NDAHQITLCL LSTNCVLDPV IYCFLTKKFR 

       310        320        330        340 
KHLSEKFYSM RSSRKCSRAT SDTCTEVMMP ANQTPVLPLK N

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA."
Bito H., Honda Z., Nakamura M., Shimizu T.
Eur. J. Biochem. 221:211-218(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U04740 mRNA. Translation: AAA18422.1.
BC072491 mRNA. Translation: AAH72491.1.
IPIIPI00207993.
PIRS43252.
RefSeqNP_445773.1. NM_053321.2.
UniGeneRn.10137.

3D structure databases

ProteinModelPortalP46002.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000017687.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP46002.

Proteomic databases

PRIDEP46002.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017687; ENSRNOP00000017687; ENSRNOG00000013231.
GeneID58949.
KEGGrno:58949.
UCSCRGD:61897. rat.

Organism-specific databases

CTD5724.
RGD61897. Ptafr.

Phylogenomic databases

eggNOGNOG149133.
GeneTreeENSGT00690000102073.
HOGENOMHOG000013041.
HOVERGENHBG101106.
InParanoidP46002.
KOK04279.
OMAYVLWVFA.
OrthoDBEOG4GHZPH.

Gene expression databases

GenevestigatorP46002.
GermOnlineENSRNOG00000013231. Rattus norvegicus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002282. PAF_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01153. PAFRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP46002.
ChEMBLCHEMBL4127.
NextBio611566.

Entry information

Entry namePTAFR_RAT
AccessionPrimary (citable) accession number: P46002
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents