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Protein

Mitogen-activated protein kinase 9

Gene

MAPK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).1 Publication
MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • JUN kinase activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • Fc-epsilon receptor signaling pathway Source: Reactome
  • JNK cascade Source: UniProtKB
  • positive regulation of apoptotic signaling pathway Source: Ensembl
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of podosome assembly Source: Ensembl
  • protein phosphorylation Source: UniProtKB
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of sequence-specific DNA binding transcription factor activity Source: Reactome
  • response to cadmium ion Source: Ensembl
  • response to stress Source: ProtInc
  • rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00637-MONOMER.
BRENDAi2.7.11.24. 2681.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-450341. Activation of the AP-1 family of transcription factors.
SignaLinkiP45984.
SIGNORiP45984.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 9 (EC:2.7.11.24)
Short name:
MAP kinase 9
Short name:
MAPK 9
Alternative name(s):
JNK-55
Stress-activated protein kinase 1a
Short name:
SAPK1a
Stress-activated protein kinase JNK2
c-Jun N-terminal kinase 2
Gene namesi
Name:MAPK9
Synonyms:JNK2, PRKM9, SAPK1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6886. MAPK9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5601.
OpenTargetsiENSG00000050748.
PharmGKBiPA30630.

Chemistry databases

ChEMBLiCHEMBL4179.
GuidetoPHARMACOLOGYi1497.

Polymorphism and mutation databases

BioMutaiMAPK9.
DMDMi85700366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862731 – 424Mitogen-activated protein kinase 9Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183Phosphothreonine; by MAP2K71 Publication1
Modified residuei185Phosphotyrosine; by MAP2K41 Publication1

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP45984.
MaxQBiP45984.
PaxDbiP45984.
PeptideAtlasiP45984.
PRIDEiP45984.

2D gel databases

REPRODUCTION-2DPAGEP45984.

PTM databases

iPTMnetiP45984.
PhosphoSitePlusiP45984.

Expressioni

Gene expression databases

BgeeiENSG00000050748.
CleanExiHS_MAPK9.
ExpressionAtlasiP45984. baseline and differential.
GenevisibleiP45984. HS.

Organism-specific databases

HPAiCAB008910.
HPA055483.

Interactioni

Subunit structurei

Interacts with MECOM and DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with BCL10. Interacts with CTNNB1 and GSK3B.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRB1P494075EBI-713568,EBI-743313
ARRB2P321217EBI-713568,EBI-714559
ATF2P153365EBI-713568,EBI-1170906
C1orf94Q6P1W53EBI-713568,EBI-946029
CEP44Q9C0F16EBI-713568,EBI-744115
CTBP1Q13363-23EBI-713568,EBI-10171858
EFHC2Q5JST65EBI-713568,EBI-2349927
L3MBTL3Q96JM73EBI-713568,EBI-2686809
LNX1Q8TBB13EBI-713568,EBI-739832
MEOX1P502215EBI-713568,EBI-2864512
SF3B4Q154276EBI-713568,EBI-348469
SHMT1P348965EBI-713568,EBI-715117
SMCO3A2RU483EBI-713568,EBI-10173195
STAT3P407633EBI-713586,EBI-518675
TEX11Q8IYF33EBI-713568,EBI-742397
WDR62O433794EBI-713568,EBI-714790

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111587. 112 interactors.
DIPiDIP-270N.
DIP-281N.
IntActiP45984. 71 interactors.
MINTiMINT-1400230.
STRINGi9606.ENSP00000389338.

Chemistry databases

BindingDBiP45984.

Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Beta strandi18 – 23Combined sources6
Beta strandi26 – 33Combined sources8
Beta strandi38 – 45Combined sources8
Turni46 – 49Combined sources4
Beta strandi50 – 58Combined sources9
Helixi64 – 79Combined sources16
Beta strandi88 – 92Combined sources5
Turni98 – 100Combined sources3
Beta strandi105 – 109Combined sources5
Beta strandi112 – 114Combined sources3
Helixi115 – 118Combined sources4
Helixi125 – 144Combined sources20
Helixi154 – 156Combined sources3
Beta strandi157 – 159Combined sources3
Beta strandi165 – 167Combined sources3
Turni176 – 178Combined sources3
Beta strandi180 – 183Combined sources4
Helixi189 – 191Combined sources3
Helixi194 – 197Combined sources4
Helixi206 – 220Combined sources15
Helixi232 – 241Combined sources10
Helixi246 – 250Combined sources5
Helixi254 – 261Combined sources8
Helixi271 – 274Combined sources4
Helixi277 – 279Combined sources3
Helixi286 – 301Combined sources16
Turni306 – 308Combined sources3
Helixi312 – 316Combined sources5
Helixi319 – 322Combined sources4
Helixi327 – 330Combined sources4
Turni341 – 343Combined sources3
Helixi349 – 360Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E7OX-ray2.14A/B7-362[»]
3NPCX-ray2.35A/B1-364[»]
ProteinModelPortaliP45984.
SMRiP45984.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45984.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 321Protein kinasePROSITE-ProRule annotationAdd BLAST296

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 185TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0665. Eukaryota.
ENOG410XSHI. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP45984.
KOiK04440.
OMAiHSIEQWK.
OrthoDBiEOG091G09G2.
PhylomeDBiP45984.
TreeFamiTF105100.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha-2 (identifier: P45984-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI
60 70 80 90 100
NVAVKKLSRP FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE
110 120 130 140 150
FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIK HLHSAGIIHR
160 170 180 190 200
DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM
210 220 230 240 250
GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK
260 270 280 290 300
KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK
310 320 330 340 350
MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE
360 370 380 390 400
EWKELIYKEV MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS
410 420
TEQTLASDTD SSLDASTGPL EGCR
Length:424
Mass (Da):48,139
Last modified:January 24, 2006 - v2
Checksum:i9C15DA79981290AF
GO
Isoform Alpha-1 (identifier: P45984-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-424: DAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR → AQMQQ

Show »
Length:382
Mass (Da):44,051
Checksum:iA1963C01247BDFF4
GO
Isoform Beta-1 (identifier: P45984-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-230: GELVKGCVIFQGTDH → AEMVLHKVLFPGRDY
     378-424: DAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR → AQMQQ

Show »
Length:382
Mass (Da):44,223
Checksum:i808ED1F85085CB4E
GO
Isoform Beta-2 (identifier: P45984-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-230: GELVKGCVIFQGTDH → AEMVLHKVLFPGRDY

Show »
Length:424
Mass (Da):48,311
Checksum:iA1B5FB794F373EB9
GO
Isoform 5 (identifier: P45984-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-242: HIDQWNKVIEQLG → RILPRDLGPAMLS
     243-424: Missing.

Show »
Length:242
Mass (Da):27,334
Checksum:iB37D5C58904AE9F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51N → S in AAA56831 (PubMed:7969172).Curated1
Sequence conflicti51N → S in AAC50606 (PubMed:8654373).Curated1
Sequence conflicti51N → S in AAC50608 (PubMed:8654373).Curated1
Sequence conflicti51N → S in AAC50609 (PubMed:8654373).Curated1
Sequence conflicti377S → P in AAA74740 (PubMed:8001819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04226013V → M in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04226156K → N in a head & Neck squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042262246A → T.1 PublicationCorresponds to variant rs35421153dbSNPEnsembl.1
Natural variantiVAR_025175268G → A.1 PublicationCorresponds to variant rs35693958dbSNPEnsembl.1
Natural variantiVAR_042263366R → I.1 PublicationCorresponds to variant rs55736180dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004834216 – 230GELVK…QGTDH → AEMVLHKVLFPGRDY in isoform Beta-1 and isoform Beta-2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_041908230 – 242HIDQW…IEQLG → RILPRDLGPAMLS in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_041909243 – 424Missing in isoform 5. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_004835378 – 424DAAVS…LEGCR → AQMQQ in isoform Alpha-1 and isoform Beta-1. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31951 mRNA. Translation: AAA56831.1.
U09759 mRNA. Translation: AAA74740.1.
U34821 mRNA. Translation: AAC50606.1.
U35002 mRNA. Translation: AAC50608.1.
U35003 mRNA. Translation: AAC50609.1.
EU927388 mRNA. Translation: ACH57450.1.
CR536580 mRNA. Translation: CAG38817.1.
AK289638 mRNA. Translation: BAF82327.1.
DQ066599 Genomic DNA. Translation: AAY46156.1.
AB451302 mRNA. Translation: BAG70116.1.
AB451355 mRNA. Translation: BAG70169.1.
AC008610 Genomic DNA. No translation available.
AC104115 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53759.1.
CH471165 Genomic DNA. Translation: EAW53757.1.
CH471165 Genomic DNA. Translation: EAW53758.1.
CH471165 Genomic DNA. Translation: EAW53762.1.
BC032539 mRNA. Translation: AAH32539.1.
CCDSiCCDS43409.1. [P45984-2]
CCDS43410.1. [P45984-3]
CCDS4453.1. [P45984-1]
CCDS4454.1. [P45984-4]
CCDS47356.1. [P45984-5]
PIRiA55480.
S71102.
RefSeqiNP_001128516.1. NM_001135044.1. [P45984-5]
NP_001295173.1. NM_001308244.1.
NP_002743.3. NM_002752.4. [P45984-1]
NP_620707.1. NM_139068.2. [P45984-2]
NP_620708.1. NM_139069.2. [P45984-3]
NP_620709.1. NM_139070.2. [P45984-4]
XP_006714954.1. XM_006714891.2. [P45984-1]
XP_016865127.1. XM_017009638.1. [P45984-4]
XP_016865130.1. XM_017009641.1. [P45984-2]
UniGeneiHs.484371.

Genome annotation databases

EnsembliENST00000343111; ENSP00000345524; ENSG00000050748. [P45984-3]
ENST00000393360; ENSP00000377028; ENSG00000050748. [P45984-2]
ENST00000425491; ENSP00000397422; ENSG00000050748. [P45984-5]
ENST00000452135; ENSP00000394560; ENSG00000050748. [P45984-1]
ENST00000455781; ENSP00000389338; ENSG00000050748. [P45984-4]
GeneIDi5601.
KEGGihsa:5601.
UCSCiuc003mls.5. human. [P45984-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31951 mRNA. Translation: AAA56831.1.
U09759 mRNA. Translation: AAA74740.1.
U34821 mRNA. Translation: AAC50606.1.
U35002 mRNA. Translation: AAC50608.1.
U35003 mRNA. Translation: AAC50609.1.
EU927388 mRNA. Translation: ACH57450.1.
CR536580 mRNA. Translation: CAG38817.1.
AK289638 mRNA. Translation: BAF82327.1.
DQ066599 Genomic DNA. Translation: AAY46156.1.
AB451302 mRNA. Translation: BAG70116.1.
AB451355 mRNA. Translation: BAG70169.1.
AC008610 Genomic DNA. No translation available.
AC104115 Genomic DNA. No translation available.
CH471165 Genomic DNA. Translation: EAW53759.1.
CH471165 Genomic DNA. Translation: EAW53757.1.
CH471165 Genomic DNA. Translation: EAW53758.1.
CH471165 Genomic DNA. Translation: EAW53762.1.
BC032539 mRNA. Translation: AAH32539.1.
CCDSiCCDS43409.1. [P45984-2]
CCDS43410.1. [P45984-3]
CCDS4453.1. [P45984-1]
CCDS4454.1. [P45984-4]
CCDS47356.1. [P45984-5]
PIRiA55480.
S71102.
RefSeqiNP_001128516.1. NM_001135044.1. [P45984-5]
NP_001295173.1. NM_001308244.1.
NP_002743.3. NM_002752.4. [P45984-1]
NP_620707.1. NM_139068.2. [P45984-2]
NP_620708.1. NM_139069.2. [P45984-3]
NP_620709.1. NM_139070.2. [P45984-4]
XP_006714954.1. XM_006714891.2. [P45984-1]
XP_016865127.1. XM_017009638.1. [P45984-4]
XP_016865130.1. XM_017009641.1. [P45984-2]
UniGeneiHs.484371.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E7OX-ray2.14A/B7-362[»]
3NPCX-ray2.35A/B1-364[»]
ProteinModelPortaliP45984.
SMRiP45984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111587. 112 interactors.
DIPiDIP-270N.
DIP-281N.
IntActiP45984. 71 interactors.
MINTiMINT-1400230.
STRINGi9606.ENSP00000389338.

Chemistry databases

BindingDBiP45984.
ChEMBLiCHEMBL4179.
GuidetoPHARMACOLOGYi1497.

PTM databases

iPTMnetiP45984.
PhosphoSitePlusiP45984.

Polymorphism and mutation databases

BioMutaiMAPK9.
DMDMi85700366.

2D gel databases

REPRODUCTION-2DPAGEP45984.

Proteomic databases

EPDiP45984.
MaxQBiP45984.
PaxDbiP45984.
PeptideAtlasiP45984.
PRIDEiP45984.

Protocols and materials databases

DNASUi5601.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343111; ENSP00000345524; ENSG00000050748. [P45984-3]
ENST00000393360; ENSP00000377028; ENSG00000050748. [P45984-2]
ENST00000425491; ENSP00000397422; ENSG00000050748. [P45984-5]
ENST00000452135; ENSP00000394560; ENSG00000050748. [P45984-1]
ENST00000455781; ENSP00000389338; ENSG00000050748. [P45984-4]
GeneIDi5601.
KEGGihsa:5601.
UCSCiuc003mls.5. human. [P45984-1]

Organism-specific databases

CTDi5601.
DisGeNETi5601.
GeneCardsiMAPK9.
HGNCiHGNC:6886. MAPK9.
HPAiCAB008910.
HPA055483.
MIMi602896. gene.
neXtProtiNX_P45984.
OpenTargetsiENSG00000050748.
PharmGKBiPA30630.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0665. Eukaryota.
ENOG410XSHI. LUCA.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP45984.
KOiK04440.
OMAiHSIEQWK.
OrthoDBiEOG091G09G2.
PhylomeDBiP45984.
TreeFamiTF105100.

Enzyme and pathway databases

BioCyciZFISH:HS00637-MONOMER.
BRENDAi2.7.11.24. 2681.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-450341. Activation of the AP-1 family of transcription factors.
SignaLinkiP45984.
SIGNORiP45984.

Miscellaneous databases

ChiTaRSiMAPK9. human.
EvolutionaryTraceiP45984.
GeneWikiiMitogen-activated_protein_kinase_9.
GenomeRNAii5601.
PROiP45984.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000050748.
CleanExiHS_MAPK9.
ExpressionAtlasiP45984. baseline and differential.
GenevisibleiP45984. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMK09_HUMAN
AccessioniPrimary (citable) accession number: P45984
Secondary accession number(s): A8K0S3
, B5BU66, B5M0B4, D3DWQ8, D3DWQ9, Q15708, Q15710, Q15711, Q8N5C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.