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P45971

- OST48_CAEEL

UniProt

P45971 - OST48_CAEEL

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Protein
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Gene
T09A5.11
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains By similarity.

Catalytic activityi

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.

Pathwayi

GO - Molecular functioni

  1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro

GO - Biological processi

  1. protein N-linked glycosylation via asparagine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_183192. Advanced glycosylation endproduct receptor signaling.
REACT_197749. SRP-dependent cotranslational protein targeting to membrane.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (EC:2.4.99.18)
Short name:
Oligosaccharyl transferase 48 kDa subunit
Gene namesi
ORF Names:T09A5.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiT09A5.11; CE01081; WBGene00011638; ostb-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 405385Lumenal Reviewed prediction
Add
BLAST
Transmembranei406 – 42621Helical; Reviewed prediction
Add
BLAST
Topological domaini427 – 44519Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 445425Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
PRO_0000021954Add
BLAST

Proteomic databases

PaxDbiP45971.

Interactioni

Subunit structurei

Component of the oligosaccharyltransferase (OST) complex By similarity.

Protein-protein interaction databases

STRINGi6239.T09A5.11.1.

Structurei

3D structure databases

ProteinModelPortaliP45971.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263094.
GeneTreeiENSGT00390000017294.
HOGENOMiHOG000173744.
InParanoidiP45971.
KOiK12670.
OMAiDVSDLGQ.
PhylomeDBiP45971.

Family and domain databases

InterProiIPR005013. WBP1.
[Graphical view]
PANTHERiPTHR10830. PTHR10830. 1 hit.
PfamiPF03345. DDOST_48kD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45971-1 [UniParc]FASTAAdd to Basket

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MRWLPGLLLI ASIGFHQSLA DRVLVLGETA AVKDTHSVFL NSVKERGHEL    50
TVRAADDSQL ALFKHGQLIF DHLFILAPGV QVFGGSLSPS EISKFVDAGG 100
NVLVAAGSNI GDALREIAAE HGFEFEEAGT SVIDHHNYDQ TLDSGDHTTL 150
VVGKDQLISA ELIVGNSAKL HPVLFKGIGL VAGKTNNLAL SIVRASGTAY 200
SYDPKAVRAT NPSIAGSRTL LVGGLQSRNN ARIVFTGSSE LFSNTFFSAK 250
TNSVNPSVQG AQSGNADFAT AITRWVMKES GVLRVKTVNH HKKGETVPPV 300
EGYFITEDVV YTIEIEELKN GKWVPFQGKD VQLEFVRIDP FVRATLKNSN 350
GRLSVAFKLP DVLGVFKFLV DYRRVGYTHL YDVQQVSVRP LWHTQYERFI 400
RSAYPYYASS FSMMAGLVLF SIVYLYHKDT PVKGAKVLDS EKKKN 445
Length:445
Mass (Da):48,760
Last modified:November 1, 1995 - v1
Checksum:i59A14E6ECF43F0F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36753 Genomic DNA. Translation: CAA85337.1.
PIRiT24723.
RefSeqiNP_495655.1. NM_063254.5.
UniGeneiCel.17464.

Genome annotation databases

EnsemblMetazoaiT09A5.11.1; T09A5.11.1; WBGene00011638.
T09A5.11.2; T09A5.11.2; WBGene00011638.
GeneIDi174268.
KEGGicel:CELE_T09A5.11.
UCSCiT09A5.11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36753 Genomic DNA. Translation: CAA85337.1 .
PIRi T24723.
RefSeqi NP_495655.1. NM_063254.5.
UniGenei Cel.17464.

3D structure databases

ProteinModelPortali P45971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T09A5.11.1.

Proteomic databases

PaxDbi P45971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T09A5.11.1 ; T09A5.11.1 ; WBGene00011638 .
T09A5.11.2 ; T09A5.11.2 ; WBGene00011638 .
GeneIDi 174268.
KEGGi cel:CELE_T09A5.11.
UCSCi T09A5.11.2. c. elegans.

Organism-specific databases

CTDi 174268.
WormBasei T09A5.11 ; CE01081 ; WBGene00011638 ; ostb-1.

Phylogenomic databases

eggNOGi NOG263094.
GeneTreei ENSGT00390000017294.
HOGENOMi HOG000173744.
InParanoidi P45971.
KOi K12670.
OMAi DVSDLGQ.
PhylomeDBi P45971.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_183192. Advanced glycosylation endproduct receptor signaling.
REACT_197749. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

NextBioi 883303.
PROi P45971.

Family and domain databases

InterProi IPR005013. WBP1.
[Graphical view ]
PANTHERi PTHR10830. PTHR10830. 1 hit.
Pfami PF03345. DDOST_48kD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiOST48_CAEEL
AccessioniPrimary (citable) accession number: P45971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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