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P45971 (OST48_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Short name=Oligosaccharyl transferase 48 kDa subunit
EC=2.4.99.18
Gene names
ORF Names:T09A5.11
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains By similarity.

Catalytic activity

Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.

Pathway

Protein modification; protein glycosylation.

Subunit structure

Component of the oligosaccharyltransferase (OST) complex By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the DDOST 48 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 445425Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
PRO_0000021954

Regions

Topological domain21 – 405385Lumenal Potential
Transmembrane406 – 42621Helical; Potential
Topological domain427 – 44519Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P45971 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 59A14E6ECF43F0F9

FASTA44548,760
        10         20         30         40         50         60 
MRWLPGLLLI ASIGFHQSLA DRVLVLGETA AVKDTHSVFL NSVKERGHEL TVRAADDSQL 

        70         80         90        100        110        120 
ALFKHGQLIF DHLFILAPGV QVFGGSLSPS EISKFVDAGG NVLVAAGSNI GDALREIAAE 

       130        140        150        160        170        180 
HGFEFEEAGT SVIDHHNYDQ TLDSGDHTTL VVGKDQLISA ELIVGNSAKL HPVLFKGIGL 

       190        200        210        220        230        240 
VAGKTNNLAL SIVRASGTAY SYDPKAVRAT NPSIAGSRTL LVGGLQSRNN ARIVFTGSSE 

       250        260        270        280        290        300 
LFSNTFFSAK TNSVNPSVQG AQSGNADFAT AITRWVMKES GVLRVKTVNH HKKGETVPPV 

       310        320        330        340        350        360 
EGYFITEDVV YTIEIEELKN GKWVPFQGKD VQLEFVRIDP FVRATLKNSN GRLSVAFKLP 

       370        380        390        400        410        420 
DVLGVFKFLV DYRRVGYTHL YDVQQVSVRP LWHTQYERFI RSAYPYYASS FSMMAGLVLF 

       430        440 
SIVYLYHKDT PVKGAKVLDS EKKKN 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36753 Genomic DNA. Translation: CAA85337.1.
PIRT24723.
RefSeqNP_495655.1. NM_063254.5.
UniGeneCel.17464.

3D structure databases

ProteinModelPortalP45971.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T09A5.11.1.

Proteomic databases

PaxDbP45971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT09A5.11.1; T09A5.11.1; T09A5.11.
T09A5.11.2; T09A5.11.2; T09A5.11.
T09A5.11.3; T09A5.11.3; T09A5.11.
GeneID174268.
KEGGcel:CELE_T09A5.11.
UCSCT09A5.11.2. c. elegans.

Organism-specific databases

CTD174268.
WormBaseT09A5.11; CE01081; WBGene00011638; ostb-1.

Phylogenomic databases

eggNOGNOG263094.
HOGENOMHOG000173744.
InParanoidP45971.
KOK12670.
OMALEHTQYE.
PhylomeDBP45971.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR005013. WBP1.
[Graphical view]
PANTHERPTHR10830. PTHR10830. 1 hit.
PfamPF03345. DDOST_48kD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883303.
PROP45971.

Entry information

Entry nameOST48_CAEEL
AccessionPrimary (citable) accession number: P45971
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase