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P45971

- OST48_CAEEL

UniProt

P45971 - OST48_CAEEL

Protein

Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Gene

T09A5.11

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.By similarity

    Catalytic activityi

    Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.

    Pathwayi

    GO - Molecular functioni

    1. dolichyl-diphosphooligosaccharide-protein glycotransferase activity Source: InterPro

    GO - Biological processi

    1. protein N-linked glycosylation via asparagine Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_183192. Advanced glycosylation endproduct receptor signaling.
    REACT_197749. SRP-dependent cotranslational protein targeting to membrane.
    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (EC:2.4.99.18)
    Short name:
    Oligosaccharyl transferase 48 kDa subunit
    Gene namesi
    ORF Names:T09A5.11
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiT09A5.11; CE01081; WBGene00011638; ostb-1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 445425Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitPRO_0000021954Add
    BLAST

    Proteomic databases

    PaxDbiP45971.

    Interactioni

    Subunit structurei

    Component of the oligosaccharyltransferase (OST) complex.By similarity

    Protein-protein interaction databases

    STRINGi6239.T09A5.11.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP45971.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 405385LumenalSequence AnalysisAdd
    BLAST
    Topological domaini427 – 44519CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DDOST 48 kDa subunit family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263094.
    GeneTreeiENSGT00390000017294.
    HOGENOMiHOG000173744.
    InParanoidiP45971.
    KOiK12670.
    OMAiDVSDLGQ.
    PhylomeDBiP45971.

    Family and domain databases

    InterProiIPR005013. WBP1.
    [Graphical view]
    PANTHERiPTHR10830. PTHR10830. 1 hit.
    PfamiPF03345. DDOST_48kD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P45971-1 [UniParc]FASTAAdd to Basket

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    MRWLPGLLLI ASIGFHQSLA DRVLVLGETA AVKDTHSVFL NSVKERGHEL    50
    TVRAADDSQL ALFKHGQLIF DHLFILAPGV QVFGGSLSPS EISKFVDAGG 100
    NVLVAAGSNI GDALREIAAE HGFEFEEAGT SVIDHHNYDQ TLDSGDHTTL 150
    VVGKDQLISA ELIVGNSAKL HPVLFKGIGL VAGKTNNLAL SIVRASGTAY 200
    SYDPKAVRAT NPSIAGSRTL LVGGLQSRNN ARIVFTGSSE LFSNTFFSAK 250
    TNSVNPSVQG AQSGNADFAT AITRWVMKES GVLRVKTVNH HKKGETVPPV 300
    EGYFITEDVV YTIEIEELKN GKWVPFQGKD VQLEFVRIDP FVRATLKNSN 350
    GRLSVAFKLP DVLGVFKFLV DYRRVGYTHL YDVQQVSVRP LWHTQYERFI 400
    RSAYPYYASS FSMMAGLVLF SIVYLYHKDT PVKGAKVLDS EKKKN 445
    Length:445
    Mass (Da):48,760
    Last modified:November 1, 1995 - v1
    Checksum:i59A14E6ECF43F0F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36753 Genomic DNA. Translation: CAA85337.1.
    PIRiT24723.
    RefSeqiNP_495655.1. NM_063254.5.
    UniGeneiCel.17464.

    Genome annotation databases

    EnsemblMetazoaiT09A5.11.1; T09A5.11.1; WBGene00011638.
    T09A5.11.2; T09A5.11.2; WBGene00011638.
    GeneIDi174268.
    KEGGicel:CELE_T09A5.11.
    UCSCiT09A5.11.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36753 Genomic DNA. Translation: CAA85337.1 .
    PIRi T24723.
    RefSeqi NP_495655.1. NM_063254.5.
    UniGenei Cel.17464.

    3D structure databases

    ProteinModelPortali P45971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T09A5.11.1.

    Proteomic databases

    PaxDbi P45971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T09A5.11.1 ; T09A5.11.1 ; WBGene00011638 .
    T09A5.11.2 ; T09A5.11.2 ; WBGene00011638 .
    GeneIDi 174268.
    KEGGi cel:CELE_T09A5.11.
    UCSCi T09A5.11.2. c. elegans.

    Organism-specific databases

    CTDi 174268.
    WormBasei T09A5.11 ; CE01081 ; WBGene00011638 ; ostb-1.

    Phylogenomic databases

    eggNOGi NOG263094.
    GeneTreei ENSGT00390000017294.
    HOGENOMi HOG000173744.
    InParanoidi P45971.
    KOi K12670.
    OMAi DVSDLGQ.
    PhylomeDBi P45971.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_183192. Advanced glycosylation endproduct receptor signaling.
    REACT_197749. SRP-dependent cotranslational protein targeting to membrane.

    Miscellaneous databases

    NextBioi 883303.
    PROi P45971.

    Family and domain databases

    InterProi IPR005013. WBP1.
    [Graphical view ]
    PANTHERi PTHR10830. PTHR10830. 1 hit.
    Pfami PF03345. DDOST_48kD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiOST48_CAEEL
    AccessioniPrimary (citable) accession number: P45971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3