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Protein

Chromo domain-containing protein cec-3

Gene

cec-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromo domain-containing protein cec-3
Gene namesi
Name:cec-3
ORF Names:T09A5.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT09A5.8; CE01089; WBGene00011636; cec-3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Expression of unc-4 in all 6 VC motor neurons in contrast to wild-type expression which is only detected in the vulval VC neurons, leading to hyperinhibition of HSN neuron activity and egg-laying defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Chromo domain-containing protein cec-3PRO_0000080243Add
BLAST

Proteomic databases

PaxDbiP45968.
PRIDEiP45968.

Interactioni

Protein-protein interaction databases

IntActiP45968. 1 interaction.
STRINGi6239.T09A5.8.

Structurei

3D structure databases

ProteinModelPortaliP45968.
SMRiP45968. Positions 22-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8461ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG277048.
HOGENOMiHOG000016666.
InParanoidiP45968.
OMAiYLLDRCE.
OrthoDBiEOG7MD4T0.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEGSREES REPEAREGKS DEIFEVEKIL AHKVTDNLLV LQVRWLGYGA
60 70 80 90 100
DEDTWEPEED LQECASEVVA EYYKKLKVTD KTELIELLQK QIKKNKSQKS
110 120 130 140 150
KKRSKTVSDH ESNHDSDGSY GTPKTSKKSK KSAKNETPVS SKVPKVPTKA
160 170 180 190 200
ALKSYEATVS GPVAPNNAKK AAMEVRDTRR NWLDEESSDD EAETTAPLSD
210 220 230 240 250
VEKIASKVKV VKAVEEKAEE PVKRPSTPPK PREVVIKKDP SESPVASASS
260 270 280 290 300
VIPTSKRKSI NAETSNGRQR TLAPPVIVKD ETTWTVDGIA RHTDVDNTKT
310 320 330
KLILMTNSAT GERKVVEGRE AFELDGWALA KYLLDRCEF
Length:339
Mass (Da):37,736
Last modified:October 31, 1995 - v1
Checksum:i9396D2A18C404241
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36753 Genomic DNA. Translation: CAA85339.1.
PIRiT24725.
RefSeqiNP_495652.1. NM_063251.6.
UniGeneiCel.7475.

Genome annotation databases

EnsemblMetazoaiT09A5.8; T09A5.8; WBGene00011636.
GeneIDi174265.
KEGGicel:CELE_T09A5.8.
UCSCiT09A5.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36753 Genomic DNA. Translation: CAA85339.1.
PIRiT24725.
RefSeqiNP_495652.1. NM_063251.6.
UniGeneiCel.7475.

3D structure databases

ProteinModelPortaliP45968.
SMRiP45968. Positions 22-76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP45968. 1 interaction.
STRINGi6239.T09A5.8.

Proteomic databases

PaxDbiP45968.
PRIDEiP45968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT09A5.8; T09A5.8; WBGene00011636.
GeneIDi174265.
KEGGicel:CELE_T09A5.8.
UCSCiT09A5.8. c. elegans.

Organism-specific databases

CTDi174265.
WormBaseiT09A5.8; CE01089; WBGene00011636; cec-3.

Phylogenomic databases

eggNOGiNOG277048.
HOGENOMiHOG000016666.
InParanoidiP45968.
OMAiYLLDRCE.
OrthoDBiEOG7MD4T0.

Miscellaneous databases

NextBioi883291.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans."
    Zheng C., Karimzadegan S., Chiang V., Chalfie M.
    PLoS Genet. 9:E1004017-E1004017(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCEC3_CAEEL
AccessioniPrimary (citable) accession number: P45968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 31, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.