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P45968

- CEC3_CAEEL

UniProt

P45968 - CEC3_CAEEL

Protein

Chromo domain-containing protein cec-3

Gene

cec-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. methyltransferase activity Source: InterPro

    GO - Biological processi

    1. DNA methylation Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromo domain-containing protein cec-3
    Gene namesi
    Name:cec-3
    ORF Names:T09A5.8
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiT09A5.8; CE01089; WBGene00011636; cec-3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: WormBase

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Expression of unc-4 in all 6 VC motor neurons in contrast to wild-type expression which is only detected in the vulval VC neurons, leading to hyperinhibition of HSN neuron activity and egg-laying defects.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Chromo domain-containing protein cec-3PRO_0000080243Add
    BLAST

    Proteomic databases

    PaxDbiP45968.
    PRIDEiP45968.

    Interactioni

    Protein-protein interaction databases

    IntActiP45968. 1 interaction.
    STRINGi6239.T09A5.8.

    Structurei

    3D structure databases

    ProteinModelPortaliP45968.
    SMRiP45968. Positions 22-76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 8461ChromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chromo domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG277048.
    HOGENOMiHOG000016666.
    InParanoidiP45968.
    OMAiYLLDRCE.
    OrthoDBiEOG7MD4T0.

    Family and domain databases

    InterProiIPR001525. C5_MeTfrase.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF00385. Chromo. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45968-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNEGSREES REPEAREGKS DEIFEVEKIL AHKVTDNLLV LQVRWLGYGA    50
    DEDTWEPEED LQECASEVVA EYYKKLKVTD KTELIELLQK QIKKNKSQKS 100
    KKRSKTVSDH ESNHDSDGSY GTPKTSKKSK KSAKNETPVS SKVPKVPTKA 150
    ALKSYEATVS GPVAPNNAKK AAMEVRDTRR NWLDEESSDD EAETTAPLSD 200
    VEKIASKVKV VKAVEEKAEE PVKRPSTPPK PREVVIKKDP SESPVASASS 250
    VIPTSKRKSI NAETSNGRQR TLAPPVIVKD ETTWTVDGIA RHTDVDNTKT 300
    KLILMTNSAT GERKVVEGRE AFELDGWALA KYLLDRCEF 339
    Length:339
    Mass (Da):37,736
    Last modified:November 1, 1995 - v1
    Checksum:i9396D2A18C404241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36753 Genomic DNA. Translation: CAA85339.1.
    PIRiT24725.
    RefSeqiNP_495652.1. NM_063251.6.
    UniGeneiCel.7475.

    Genome annotation databases

    EnsemblMetazoaiT09A5.8; T09A5.8; WBGene00011636.
    GeneIDi174265.
    KEGGicel:CELE_T09A5.8.
    UCSCiT09A5.8. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36753 Genomic DNA. Translation: CAA85339.1 .
    PIRi T24725.
    RefSeqi NP_495652.1. NM_063251.6.
    UniGenei Cel.7475.

    3D structure databases

    ProteinModelPortali P45968.
    SMRi P45968. Positions 22-76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P45968. 1 interaction.
    STRINGi 6239.T09A5.8.

    Proteomic databases

    PaxDbi P45968.
    PRIDEi P45968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T09A5.8 ; T09A5.8 ; WBGene00011636 .
    GeneIDi 174265.
    KEGGi cel:CELE_T09A5.8.
    UCSCi T09A5.8. c. elegans.

    Organism-specific databases

    CTDi 174265.
    WormBasei T09A5.8 ; CE01089 ; WBGene00011636 ; cec-3.

    Phylogenomic databases

    eggNOGi NOG277048.
    HOGENOMi HOG000016666.
    InParanoidi P45968.
    OMAi YLLDRCE.
    OrthoDBi EOG7MD4T0.

    Miscellaneous databases

    NextBioi 883291.

    Family and domain databases

    InterProi IPR001525. C5_MeTfrase.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF00385. Chromo. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans."
      Zheng C., Karimzadegan S., Chiang V., Chalfie M.
      PLoS Genet. 9:E1004017-E1004017(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCEC3_CAEEL
    AccessioniPrimary (citable) accession number: P45968
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3