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P45968

- CEC3_CAEEL

UniProt

P45968 - CEC3_CAEEL

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Protein

Chromo domain-containing protein cec-3

Gene

cec-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc-4 is expressed in the vulval but not in the non-vulval VC neurons.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromo domain-containing protein cec-3
Gene namesi
Name:cec-3
ORF Names:T09A5.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiT09A5.8; CE01089; WBGene00011636; cec-3.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Expression of unc-4 in all 6 VC motor neurons in contrast to wild-type expression which is only detected in the vulval VC neurons, leading to hyperinhibition of HSN neuron activity and egg-laying defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Chromo domain-containing protein cec-3PRO_0000080243Add
BLAST

Proteomic databases

PaxDbiP45968.
PRIDEiP45968.

Interactioni

Protein-protein interaction databases

IntActiP45968. 1 interaction.
STRINGi6239.T09A5.8.

Structurei

3D structure databases

ProteinModelPortaliP45968.
SMRiP45968. Positions 22-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 8461ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG277048.
HOGENOMiHOG000016666.
InParanoidiP45968.
OMAiYLLDRCE.
OrthoDBiEOG7MD4T0.

Family and domain databases

InterProiIPR001525. C5_MeTfrase.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45968-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNEGSREES REPEAREGKS DEIFEVEKIL AHKVTDNLLV LQVRWLGYGA
60 70 80 90 100
DEDTWEPEED LQECASEVVA EYYKKLKVTD KTELIELLQK QIKKNKSQKS
110 120 130 140 150
KKRSKTVSDH ESNHDSDGSY GTPKTSKKSK KSAKNETPVS SKVPKVPTKA
160 170 180 190 200
ALKSYEATVS GPVAPNNAKK AAMEVRDTRR NWLDEESSDD EAETTAPLSD
210 220 230 240 250
VEKIASKVKV VKAVEEKAEE PVKRPSTPPK PREVVIKKDP SESPVASASS
260 270 280 290 300
VIPTSKRKSI NAETSNGRQR TLAPPVIVKD ETTWTVDGIA RHTDVDNTKT
310 320 330
KLILMTNSAT GERKVVEGRE AFELDGWALA KYLLDRCEF
Length:339
Mass (Da):37,736
Last modified:November 1, 1995 - v1
Checksum:i9396D2A18C404241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36753 Genomic DNA. Translation: CAA85339.1.
PIRiT24725.
RefSeqiNP_495652.1. NM_063251.6.
UniGeneiCel.7475.

Genome annotation databases

EnsemblMetazoaiT09A5.8; T09A5.8; WBGene00011636.
GeneIDi174265.
KEGGicel:CELE_T09A5.8.
UCSCiT09A5.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36753 Genomic DNA. Translation: CAA85339.1 .
PIRi T24725.
RefSeqi NP_495652.1. NM_063251.6.
UniGenei Cel.7475.

3D structure databases

ProteinModelPortali P45968.
SMRi P45968. Positions 22-76.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P45968. 1 interaction.
STRINGi 6239.T09A5.8.

Proteomic databases

PaxDbi P45968.
PRIDEi P45968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T09A5.8 ; T09A5.8 ; WBGene00011636 .
GeneIDi 174265.
KEGGi cel:CELE_T09A5.8.
UCSCi T09A5.8. c. elegans.

Organism-specific databases

CTDi 174265.
WormBasei T09A5.8 ; CE01089 ; WBGene00011636 ; cec-3.

Phylogenomic databases

eggNOGi NOG277048.
HOGENOMi HOG000016666.
InParanoidi P45968.
OMAi YLLDRCE.
OrthoDBi EOG7MD4T0.

Miscellaneous databases

NextBioi 883291.

Family and domain databases

InterProi IPR001525. C5_MeTfrase.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00385. Chromo. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans."
    Zheng C., Karimzadegan S., Chiang V., Chalfie M.
    PLoS Genet. 9:E1004017-E1004017(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCEC3_CAEEL
AccessioniPrimary (citable) accession number: P45968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3