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Reviewed, UniProtKB/Swiss-Prot P45963 (ACR7_CAEEL)

Last modified November 24, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Acetylcholine receptor subunit alpha-type acr-7
Gene names
Name: acr-7
ORF Names: T09A5.3
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane By similarity.

Subunit structure

Forms a homo-oligomeric channel blocked by alpha-bungarotoxin. The structure is probably pentameric By similarity.

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein Probable. Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 538511Acetylcholine receptor subunit alpha-type acr-7
PRO_0000000400

Regions

Topological domain28 – 250223Extracellular Potential
Transmembrane251 – 27121 Potential
Transmembrane280 – 30021 Potential
Transmembrane313 – 33321 Potential
Topological domain334 – 513180Cytoplasmic Potential
Transmembrane514 – 53421 Potential

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Ref.3
Disulfide bond160 ↔ 174 By similarity
Disulfide bond229 ↔ 230Associated with receptor activation By similarity

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Sequences

Sequence LengthMass (Da)Tools
P45963-1 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: A33C6514FF64F56C

FASTA53862,823
        10         20         30         40         50         60 
MMVQSIQIVL PVALFFLIVF NGFTVEGSKK EAQLYRDLLT NYSYLVRPVR NPKKALTVTM 

        70         80         90        100        110        120 
KVFIQQVLLV DAKHQMIEVN AWLKYIWTDF RLRWNPLDYE NITSVRFQGE DQIWQPDILL 

       130        140        150        160        170        180 
YNRYIEDEQE SFDITYKTNA VAYSDGVINW IPPGIFKLSC KMDITLFPFD EQICFMKFGS 

       190        200        210        220        230        240 
WTYHGFALDL RLDVVKGQEP SADLSTYITN GEWHLLSAPA RREEKFYKCC KEPYPTVKFY 

       250        260        270        280        290        300 
LHLRRRTFYY VFNVVLPTLL VSFMSLLAFC LPATDLSEKI GLQTTILLSV CFFLTILSEM 

       310        320        330        340        350        360 
TPTTSEAVPL LGVFFSALTF IVAMSTTFTI LVLNIRYRQI TNHYLSPMFR SIFLECLPWL 

       370        380        390        400        410        420 
MMMKRPDHKF RRGSSYRDSS ADQCVQCAKN AELKSILRGT DNQQQIETNT FYPFPTETLS 

       430        440        450        460        470        480 
LNRKVGDGLF IQRRCQIHEE ARSEKFTHGM LACEKSLREN GSELANILVT ILKMYEVMVS 

       490        500        510        520        530 
QVERIRKRIA LKRKRKDIQD EWKFAAQAVD RFCLIIFTIV FIICCFIFVA IPPIKILD

« Hide

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References

« Hide 'large scale' references
[1]"An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans."
Mongan N.P., Baylis H.A., Adcock C., Smith G.R., Sansom M.S.P., Sattelle D.B.
Recept. Channels 6:213-228(1998) [PubMed: 10100329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed: 17761667] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-101, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF187012 mRNA. Translation: AAG35182.1.
Z36753 Genomic DNA. Translation: CAA85338.2.
PIRT24724.
RefSeqNP_495647.1.
UniGeneCel.19448

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblT09A5.3; T09A5.3; T09A5.3; Caenorhabditis elegans. [Genome view]
GeneID174262.
KEGGcel:T09A5.3.
NMPDRfig|6239.3.peg.6386.
UCSCT09A5.3. c. elegans.

Organism-specific databases

CTD174262.
WormBaseWBGene00000046. acr-7.
WormPepT09A5.3. CE28078. [WorfDB]

Phylogenomic databases

OMAVINWIPP

Family and domain databases

InterProIPR006029. Neu_channel_TM.
IPR006202. Neur_chan_lig_bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
Gene3DG3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
PANTHERPTHR18945. Neur_channel. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00252. NRIONCHANNEL.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio883279.

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Entry information

Entry nameACR7_CAEEL
AccessionPrimary (citable) accession number: P45963
Secondary accession number(s): Q9GQV0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 27, 2002
Last modified: November 24, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents