Reviewed, UniProtKB/Swiss-Prot P45959 (ALDH2_BACST)

Names and origin

Protein names	Recommended name:     Aldehyde dehydrogenase     EC=1.2.1.3
Organism	Bacillus stearothermophilus (Geobacillus stearothermophilus)
Taxonomic identifier	1422 [NCBI]
Taxonomic lineage	Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	73 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›73	›73	Aldehyde dehydrogenase		PRO_0000056443
Experimental info
	Non-terminal residue	73	1

Sequences

	Sequence		Length	Mass (Da)
	P45959-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A023C282B453C9AD	FASTA	73	7,946
	10 20 30 40 50 60 MMSSIAAPKL KEKVEKFLSG KKKMYINGSF VESASGKTFD TPNPATGERL ATVYEGDAED 70 IDRAVKAARE AFD

References

[1]	"Gene structure and amino acid sequences of alcohol dehydrogenases of Bacillus stearothermophilus." Robinson G.A., Bailey C.J., Dowds B.C.A. Biochim. Biophys. Acta 1218:432-434(1994) [PubMed: 8049268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 2334 / Var. Non-diastaticus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z25544 Genomic DNA. Translation: CAA80990.1.
PIR	S47644.
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_BACST

Accession

Primary (citable) accession number: P45959

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 4, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)