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P45959 (ALDH2_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

EC=1.2.1.3
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length73 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processethanol catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›73›73Aldehyde dehydrogenase
PRO_0000056443

Experimental info

Non-terminal residue731

Sequences

Sequence LengthMass (Da)Tools
P45959 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A023C282B453C9AD

FASTA737,946
        10         20         30         40         50         60 
MMSSIAAPKL KEKVEKFLSG KKKMYINGSF VESASGKTFD TPNPATGERL ATVYEGDAED 

        70 
IDRAVKAARE AFD 

« Hide

References

[1]"Gene structure and amino acid sequences of alcohol dehydrogenases of Bacillus stearothermophilus."
Robinson G.A., Bailey C.J., Dowds B.C.A.
Biochim. Biophys. Acta 1218:432-434(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 2334 / Var. Non-diastaticus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z25544 Genomic DNA. Translation: CAA80990.1.
PIRS47644.

3D structure databases

ProteinModelPortalP45959.
SMRP45959. Positions 23-72.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00780; UER00768.

Family and domain databases

Gene3D3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALDH2_GEOSE
AccessionPrimary (citable) accession number: P45959
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways