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Protein

Protein ArsC

Gene

arsC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciBSUB:BSU25780-MONOMER.
BRENDAi1.20.4.B2. 658.
SABIO-RKP45947.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsCUniRule annotation
Alternative name(s):
Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifierUniRule annotation
Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Synonyms:yqcM
Ordered Locus Names:BSU25780
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Protein ArsCPRO_0000162520Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP45947.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014101.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 1512Combined sources
Helixi16 – 2712Combined sources
Turni28 – 303Combined sources
Beta strandi32 – 409Combined sources
Helixi46 – 549Combined sources
Helixi59 – 613Combined sources
Helixi69 – 724Combined sources
Beta strandi76 – 805Combined sources
Helixi83 – 886Combined sources
Beta strandi96 – 1005Combined sources
Helixi106 – 1083Combined sources
Helixi113 – 13725Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JL3X-ray1.60A/B/C/D1-139[»]
1Z2DNMR-A1-139[»]
1Z2ENMR-A1-139[»]
2IPANMR-B1-139[»]
ProteinModelPortaliP45947.
SMRiP45947. Positions 3-139.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45947.

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
InParanoidiP45947.
KOiK03741.
OMAiEMRIVIT.
PhylomeDBiP45947.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P45947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKIIYFLC TGNSCRSQMA EGWAKQYLGD EWKVYSAGIE AHGLNPNAVK
60 70 80 90 100
AMKEVGIDIS NQTSDIIDSD ILNNADLVVT LCGDAADKCP MTPPHVKREH
110 120 130
WGFDDPARAQ GTEEEKWAFF QRVRDEIGNR LKEFAETGK
Length:139
Mass (Da):15,595
Last modified:November 1, 1995 - v1
Checksum:i880EE1C77D1FE130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32216 Genomic DNA. Translation: BAA06970.1.
D84432 Genomic DNA. Translation: BAA12434.1.
AL009126 Genomic DNA. Translation: CAB14519.1.
PIRiC69950.
RefSeqiNP_390455.1. NC_000964.3.
WP_004398596.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14519; CAB14519; BSU25780.
GeneIDi937801.
KEGGibsu:BSU25780.
PATRICi18977000. VBIBacSub10457_2689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32216 Genomic DNA. Translation: BAA06970.1.
D84432 Genomic DNA. Translation: BAA12434.1.
AL009126 Genomic DNA. Translation: CAB14519.1.
PIRiC69950.
RefSeqiNP_390455.1. NC_000964.3.
WP_004398596.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JL3X-ray1.60A/B/C/D1-139[»]
1Z2DNMR-A1-139[»]
1Z2ENMR-A1-139[»]
2IPANMR-B1-139[»]
ProteinModelPortaliP45947.
SMRiP45947. Positions 3-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014101.

Proteomic databases

PaxDbiP45947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14519; CAB14519; BSU25780.
GeneIDi937801.
KEGGibsu:BSU25780.
PATRICi18977000. VBIBacSub10457_2689.

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
InParanoidiP45947.
KOiK03741.
OMAiEMRIVIT.
PhylomeDBiP45947.

Enzyme and pathway databases

BioCyciBSUB:BSU25780-MONOMER.
BRENDAi1.20.4.B2. 658.
SABIO-RKP45947.

Miscellaneous databases

EvolutionaryTraceiP45947.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
[Graphical view]
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSC_BACSU
AccessioniPrimary (citable) accession number: P45947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.