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Protein

Arsenite resistance protein ArsB

Gene

arsB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump.1 Publication

Miscellaneous

Deletion of the arsB gene results in both an aresenite- and arsenate-sensitive phenotype in the absence of IPTG.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processArsenical resistance, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU25790-MONOMER.

Protein family/group databases

TCDBi2.A.59.1.2. the arsenical resistance-3 (acr3) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenite resistance protein ArsB
Gene namesi
Name:arsB
Synonyms:yqcL
Ordered Locus Names:BSU25790
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei285 – 307HelicalSequence analysisAdd BLAST23
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002014821 – 346Arsenite resistance protein ArsBAdd BLAST346

Proteomic databases

PaxDbiP45946.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014106.

Structurei

3D structure databases

ProteinModelPortaliP45946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D6J. Bacteria.
COG0798. LUCA.
HOGENOMiHOG000112302.
InParanoidiP45946.
KOiK03325.
OMAiCTAMVLM.
PhylomeDBiP45946.

Family and domain databases

InterProiView protein in InterPro
IPR004706. Arsenical-R_Acr3.
IPR002657. BilAc:Na_symport/Acr3.
PANTHERiPTHR43057. PTHR43057. 1 hit.
PfamiView protein in Pfam
PF01758. SBF. 1 hit.
PIRSFiPIRSF005508. Acr3. 1 hit.
TIGRFAMsiTIGR00832. acr3. 1 hit.

Sequencei

Sequence statusi: Complete.

P45946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLSFLDRY LTIWIFLAMA LGIGLGFIFP SFVGGLNKLQ VGTTSIPLAI
60 70 80 90 100
GLVLMMYPPL AKVRYEEIGR VFKDIKVLIL SLVQNWIIGP TLMFILAIIF
110 120 130 140 150
LPDKPEYMIG LIMIGLARCI AMVIVWNDLS KGDTEYAAGL VAFNSIFQML
160 170 180 190 200
FFSVYAYIFV TVIPQWLGME GAVVNITMAE VAKSVFIYLG VPFIAGMVTR
210 220 230 240 250
YIFVKVKGKE WYEKVFIPKI SPITLIALLF TIIVMFSLKG DVIVSLPLDV
260 270 280 290 300
VRVAIPLLIY FVLMFFVSFF LGKKIGANYA VTTTLAFTAG SNNFELAIAV
310 320 330 340
AVGVFGIHSG AAFAAVIGPL VEVPVMIALV KVALWFQRKY FGSHSM
Length:346
Mass (Da):38,312
Last modified:July 7, 2009 - v2
Checksum:i05739D0B768A8644
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152F → S in BAA06969 (PubMed:7704261).Curated1
Sequence conflicti152F → S in BAA12433 (PubMed:8969508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32216 Genomic DNA. Translation: BAA06969.1.
D84432 Genomic DNA. Translation: BAA12433.1.
AL009126 Genomic DNA. Translation: CAB14520.2.
PIRiB69950.
RefSeqiNP_390456.2. NC_000964.3.
WP_004398718.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14520; CAB14520; BSU25790.
GeneIDi937800.
KEGGibsu:BSU25790.
PATRICifig|224308.179.peg.2803.

Similar proteinsi

Entry informationi

Entry nameiARSB_BACSU
AccessioniPrimary (citable) accession number: P45946
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 7, 2009
Last modified: September 27, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families