Dwarfin sma-4 - Caenorhabditis elegans

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P45897 (SMA4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 93. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Dwarfin sma-4

Alternative name(s):
MAD protein homolog 3

Gene names

Name:	sma-4
Synonyms:	cem-3
ORF Names:	R12B2.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in TGF-beta pathway.
Subcellular location	Cytoplasm. Nucleus Probable.
Sequence similarities	Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain.
Sequence caution	The sequence CCD73313.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	body morphogenesis Inferred from mutant phenotype. Source: WormBase dauer larval development Inferred from genetic interaction. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase negative regulation of vulval development Inferred from mutant phenotype. Source: WormBase positive regulation of cell size Inferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase positive regulation of organ growth Inferred from mutant phenotype. Source: WormBase positive regulation of protein catabolic process Inferred from mutant phenotype. Source: WormBase tail tip morphogenesis Inferred from mutant phenotype. Source: WormBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription factor complex Inferred from electronic annotation. Source: InterPro
Molecular function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 570

570

Dwarfin sma-4

PRO_0000090881

Regions

Domain

150 – 273

124

MH1

Domain

350 – 570

221

MH2

Sequences

Sequence

Length

Mass (Da)

Tools

P45897 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EFDC218B9FC336AD
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FASTA

570

63,369

        10         20         30         40         50         60 
MFHPGMTSQP STSNQMYYDP LYGAEQIVQC NPMDYHQANI LCGMQYFNNS HNRYPLLPQM 

        70         80         90        100        110        120 
PPQFTNDHPY DFPNVPTIST LDEASSFNGF LIPSQPSSYN NNNISCVFTP TPCTSSQASS 

       130        140        150        160        170        180 
QPPPTPTVNP TPIPPNAGAV LTTAMDSCQQ ISHVLQCYQQ GGEDSDFVRK AIESLVKKLK 

       190        200        210        220        230        240 
DKRIELDALI TAVTSNGKQP TGCVTIQRSL DGRLQVAGRK GVPHVVYARI WRWPKVSKNE 

       250        260        270        280        290        300 
LVKLVQCQTS SDHPDNICIN PYHYERVVSN RITSADQSLH VENSPMKSEY LGDAGVIDSC 

       310        320        330        340        350        360 
SDWPNTPPDN NFNGGFAPDQ PQLVTPIISD IPIDLNQIYV PTPPQLLDNW CSIIYYELDT 

       370        380        390        400        410        420 
PIGETFKVSA RDHGKVIVDG GMDPHGENEG RLCLGALSNV HRTEASEKAR IHIGRGVELT 

       430        440        450        460        470        480 
AHADGNISIT SNCKIFVRSG YLDYTHGSEY SSKAHRFTPN ESSFTVFDIR WAYMQMLRRS 

       490        500        510        520        530        540 
RSSNEAVRAQ AAAVAGYAPM SVMPAIMPDS GVDRMRRDFC TIAISFVKAW GDVYQRKTIK 

       550        560        570 
ETPCWIEVTL HRPLQILDQL LKNSSQFGSS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components." Savage C., Das P., Finelli A.L., Townsend S.R., Sun C.-Y., Baird S.E., Padgett R.W. Proc. Natl. Acad. Sci. U.S.A. 93:790-794(1996) [PubMed: 8570636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster." Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., Gelbart W.M. Genetics 139:1347-1358(1995) [PubMed: 7768443] [Abstract] Cited for: GENE NAME CEM-3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U34596 mRNA. Translation: AAA97605.1. FO081686 Genomic DNA. Translation: CCD73313.1. Different initiation.
PIR	T16725.
RefSeq	NP_001040864.1. NM_001047399.1.
UniGene	Cel.19734.
3D structure databases
ProteinModelPortal	P45897.
SMR	P45897. Positions 143-269, 346-569.
ModBase	Search...
Protein-protein interaction databases
IntAct	P45897. 14 interactions.
MINT	MINT-1045366.
STRING	P45897.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	175815.
KEGG	cel:R12B2.1.
UCSC	R12B2.1a.1. c. elegans.
Organism-specific databases
CTD	175815.
WormBase	R12B2.1a; CE25077; WBGene00004858; sma-4.
Phylogenomic databases
eggNOG	meNOG06918.
HOGENOM	HBG443554.
InParanoid	P45897.
Gene expression databases
ArrayExpress	P45897.
Family and domain databases
InterPro	IPR013790. Dwarfin. IPR003619. MAD_homology1_Dwarfin-type. IPR013019. MAD_homology_MH1. IPR017855. SMAD_dom-like. IPR001132. SMAD_dom_Dwarfin-type. IPR008984. SMAD_FHA_domain. [Graphical view]
Gene3D	G3DSA:3.90.520.10. MAD_MH1. 1 hit. G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
KO	K04501.
PANTHER	PTHR13703. Dwarfin. 1 hit.
Pfam	PF03165. MH1. 1 hit. PF03166. MH2. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. SM00524. DWB. 1 hit. [Graphical view]
SUPFAM	SSF56366. MAD_MH1. 1 hit. SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS51075. MH1. 1 hit. PS51076. MH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SMA4_CAEEL

Accession

Primary (citable) accession number: P45897

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents