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Reviewed, UniProtKB/Swiss-Prot P45897 (SMA4_CAEEL)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dwarfin sma-4
Alternative name(s):
    MAD protein homolog 3
Gene names
Name: sma-4
Synonyms: cem-3
ORF Names: R12B2.1
OrganismCaenorhabditis elegans [Complete proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in TGF-beta pathway.

Subcellular location

Cytoplasm. Nucleus Probable.

Sequence similarities

Belongs to the dwarfin/SMAD family.

Contains 1 MH1 (MAD homology 1) domain.

Contains 1 MH2 (MAD homology 2) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Dwarfin sma-4
PRO_0000090881

Regions

Domain150 – 273124MH1
Domain350 – 570221MH2

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Sequences

Sequence LengthMass (Da)Tools
P45897-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EFDC218B9FC336AD

FASTA57063,369
        10         20         30         40         50         60 
MFHPGMTSQP STSNQMYYDP LYGAEQIVQC NPMDYHQANI LCGMQYFNNS HNRYPLLPQM 

        70         80         90        100        110        120 
PPQFTNDHPY DFPNVPTIST LDEASSFNGF LIPSQPSSYN NNNISCVFTP TPCTSSQASS 

       130        140        150        160        170        180 
QPPPTPTVNP TPIPPNAGAV LTTAMDSCQQ ISHVLQCYQQ GGEDSDFVRK AIESLVKKLK 

       190        200        210        220        230        240 
DKRIELDALI TAVTSNGKQP TGCVTIQRSL DGRLQVAGRK GVPHVVYARI WRWPKVSKNE 

       250        260        270        280        290        300 
LVKLVQCQTS SDHPDNICIN PYHYERVVSN RITSADQSLH VENSPMKSEY LGDAGVIDSC 

       310        320        330        340        350        360 
SDWPNTPPDN NFNGGFAPDQ PQLVTPIISD IPIDLNQIYV PTPPQLLDNW CSIIYYELDT 

       370        380        390        400        410        420 
PIGETFKVSA RDHGKVIVDG GMDPHGENEG RLCLGALSNV HRTEASEKAR IHIGRGVELT 

       430        440        450        460        470        480 
AHADGNISIT SNCKIFVRSG YLDYTHGSEY SSKAHRFTPN ESSFTVFDIR WAYMQMLRRS 

       490        500        510        520        530        540 
RSSNEAVRAQ AAAVAGYAPM SVMPAIMPDS GVDRMRRDFC TIAISFVKAW GDVYQRKTIK 

       550        560        570 
ETPCWIEVTL HRPLQILDQL LKNSSQFGSS

« Hide

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References

« Hide 'large scale' references
[1]"Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components."
Savage C., Das P., Finelli A.L., Townsend S.R., Sun C.-Y., Baird S.E., Padgett R.W.
Proc. Natl. Acad. Sci. U.S.A. 93:790-794(1996) [PubMed: 8570636] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster."
Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., Gelbart W.M.
Genetics 139:1347-1358(1995) [PubMed: 7768443] [Abstract]
Cited for: GENE NAME CEM-3.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U34596 mRNA. Translation: AAA97605.1.
U00066 Genomic DNA. Translation: AAA50739.2. Different initiation.
PIRT16725.
UniGeneCel.19734

3D structure databases

HSSPHSSP built from PDB template 1YGS based on UniProtKB Q13485.
ModBaseSearch...

Protein-protein interaction databases

IntActP45897. 33 interactions.

Genome annotation databases

EnsemblR12B2.1. Caenorhabditis elegans. [Contig view]

Organism-specific databases

WormBaseWBGene00004858. sma-4.
WormPepR12B2.1. CE01364. [WorfDB]

Gene expression databases

ArrayExpressP45897.

Family and domain databases

InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
[Graphical view]
Gene3DG3DSA:3.90.520.10. MAD_MH1. 1 hit.
G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit.
PANTHERPTHR13703. Dwarfin. 1 hit.
PfamPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
PROSITEPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSMA4_CAEEL
AccessionPrimary (citable) accession number: P45897
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectCaenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents