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Protein

Dwarfin sma-3

Gene

sma-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in TGF-beta pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65ZincBy similarity1
Metal bindingi110ZincBy similarity1
Metal bindingi124ZincBy similarity1
Metal bindingi129ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: WormBase
  • defense response to fungus Source: WormBase
  • innate immune response Source: WormBase
  • nematode larval development Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase
  • pharynx development Source: UniProtKB
  • positive regulation of cell size Source: WormBase
  • positive regulation of multicellular organism growth Source: WormBase
  • positive regulation of organ growth Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • regulation of mesodermal cell fate specification Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-1181150. Signaling by NODAL.
R-CEL-1502540. Signaling by Activin.
R-CEL-201451. Signaling by BMP.
R-CEL-2173788. Downregulation of TGF-beta receptor signaling.
R-CEL-2173789. TGF-beta receptor signaling activates SMADs.
R-CEL-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-CEL-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-8941855. RUNX3 regulates CDKN1A transcription.
SignaLinkiP45896.

Names & Taxonomyi

Protein namesi
Recommended name:
Dwarfin sma-3
Alternative name(s):
MAD protein homolog 2
Gene namesi
Name:sma-3
Synonyms:cem-2
ORF Names:R13F6.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR13F6.9; CE25974; WBGene00004857; sma-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908801 – 393Dwarfin sma-3Add BLAST393

Proteomic databases

PaxDbiP45896.
PeptideAtlasiP45896.

Expressioni

Gene expression databases

BgeeiWBGene00004857.

Interactioni

Protein-protein interaction databases

BioGridi41170. 14 interactors.
IntActiP45896. 16 interactors.
MINTiMINT-1039136.
STRINGi6239.R13F6.9.

Structurei

3D structure databases

ProteinModelPortaliP45896.
SMRiP45896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 139MH1PROSITE-ProRule annotationAdd BLAST130
Domaini197 – 393MH2PROSITE-ProRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

eggNOGiKOG3701. Eukaryota.
ENOG410XQKU. LUCA.
GeneTreeiENSGT00760000119091.
HOGENOMiHOG000286018.
InParanoidiP45896.
KOiK04676.
OMAiCFIRISF.
OrthoDBiEOG091G082C.
PhylomeDBiP45896.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiView protein in InterPro
IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiView protein in Pfam
PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiView protein in PROSITE
PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.

Sequencei

Sequence statusi: Complete.

P45896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGLLHMHGP AVKKLLGWKI GEDEEKWCEK AVEALVKKLK KKNNGCGTLE
60 70 80 90 100
DLECVLANPC TNSRCITIAK SLDGRLQVSH KKGLPHVIYC RVWRWPDISS
110 120 130 140 150
PHELRSIDTC SYPYESSSKT MYICINPYHY QRLSRPQGLN SSMPSPQPIS
160 170 180 190 200
SPNTIWQSSG SSTASCASSP SPSVFSEDGG EVQVHQRPPP FRHPKSWAQI
210 220 230 240 250
TYFELNSRVG EVFKLVNLSI TVDGYTNPSN SNTRICLGQL TNVNRNGTIE
260 270 280 290 300
NTRMHIGKGI QLDNKEDQMH IMITNNSDMP VFVQSKNTNL MMNMPLVKVC
310 320 330 340 350
RIPPHSQLCV FEFNLFFQML EQSCNDSDGL NELSKHCFIR ISFVKGWGED
360 370 380 390
YPRQDVTSTP CWLELRLNVP LAYIDQKMKQ TPRTNLMEPN SMT
Length:393
Mass (Da):44,527
Last modified:November 1, 1995 - v1
Checksum:iD3C4601CA291D8C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34902 mRNA. Translation: AAA97607.1.
FO081247 Genomic DNA. Translation: CCD70180.1.
PIRiT16750.
RefSeqiNP_498493.1. NM_066092.3.
UniGeneiCel.19733.

Genome annotation databases

EnsemblMetazoaiR13F6.9; R13F6.9; WBGene00004857.
GeneIDi175955.
KEGGicel:CELE_R13F6.9.
UCSCiR13F6.9. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiSMA3_CAEEL
AccessioniPrimary (citable) accession number: P45896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families