P45890 (ARP6_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-like protein 13E

Alternative name(s):
Actin-related protein 6
Short name=dArp6

Gene names

Name:	Actr13E
Synonyms:	Acrp
ORF Names:	CG11678

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus. Cytoplasm › cytoskeleton. Note: Localized on centric heterochromatin.
Sequence similarities	Belongs to the actin family. ARP6 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Actin-like protein 13E		PRO_0000089108

Sequences

	Sequence		Length	Mass (Da)
	P45890 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 71905627B3F0FC05	FASTA	398	45,415
	10 20 30 40 50 60 MANAVVVLDN GAHTAKVGLA NQDEPHVVPN CIMKAKSERR RAFVGNQIDE CRDTSALYYI 70 80 90 100 110 120 LAFQRGYLLN WHTQKTVWDY IFSKDGIGCS LENRNIVITE PQMNFQSIQE ATLEILFEEY 130 140 150 160 170 180 KVDGVYKTTA ADLAAFNYVA DSEERTTMES LNCIIIDVGY SFTHVVPFVL GRRVLQGIRR 190 200 210 220 230 240 IDMGGKALTN QLKELISYRH LNVMDESHVV NQIKEDVCFV AEDFKQAMQV HYSEEKRREV 250 260 270 280 290 300 TVDYVLPDFT TVKRGYVRVP GKPREDEEQQ QMVSLCNERF TVPELLFNPS DIGVQQVGIP 310 320 330 340 350 360 EAVADCLKAC PWEAHRELLL NILIVGGSAQ FPGFLPRLKR DLRALVPDDL EVSLICPEDP 370 380 390 VRYAWYGGKE VATSPNFEEF VYTQDDYEEY GFQGINQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a divergent actin-related protein in Drosophila." Frankel S., Heintzelman M.B., Artavanis-Tsakonas S., Mooseker M.S. J. Mol. Biol. 235:1351-1356(1994) [PubMed: 8308899] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25314 mRNA. Translation: AAA17685.1. AE014298 Genomic DNA. Translation: AAF48499.1. AY058726 mRNA. Translation: AAL13955.1.
PIR	S44028.
RefSeq	NP_511165.1. NM_078610.2.
UniGene	Dm.19111.
3D structure databases
ProteinModelPortal	P45890.
SMR	P45890. Positions 3-398.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-17460N.
IntAct	P45890. 4 interactions.
MINT	MINT-295789.
STRING	P45890.
Proteomic databases
PRIDE	P45890.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0074203; FBpp0073983; FBgn0011741.
GeneID	32514.
KEGG	dme:Dmel_CG11678.
NMPDR	fig|7227.3.peg.17988.
Organism-specific databases
CTD	32514.
FlyBase	FBgn0011741. Actr13E.
Phylogenomic databases
eggNOG	inNOG07981.
GeneTree	EMGT00050000003738.
InParanoid	P45890.
OMA	QKTVWDY.
OrthoDB	EOG4KD52F.
PhylomeDB	P45890.
Gene expression databases
Bgee	P45890.
GermOnline	CG11678. Drosophila melanogaster.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
KO	K11662.
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	778857.

Entry information

Entry name

ARP6_DROME

Accession

Primary (citable) accession number: P45890
Secondary accession number(s): Q9VXQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project