Reviewed, UniProtKB/Swiss-Prot P45884 (ATTA_DROME)

Names and origin

Protein names

Recommended name:
    Attacin-A

Gene names

Name:	AttA
ORF Names:	CG10146

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hemolymph antibacterial protein.
Subcellular location	Secreted.
Sequence similarities	Belongs to the attacin/sarcotoxin-2 family.

Ontologies

Keywords
Biological process	Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial
PTM	Cleavage on pair of basic residues
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antibacterial humoral response Inferred from expression pattern. Source: FlyBase defense response to Gram-negative bacterium Ref.2 Inferred from expression pattern. Source: FlyBase innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 34	14	Potential		PRO_0000004893
	Chain	35 – 224	190	Attacin-A		PRO_0000004894
Experimental info
	Sequence conflict	3	1	K → N in AAF58215. Ref.3
	Sequence conflict	22 – 24	3	Missing in AAF58215. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P45884-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 6B1965557847BBBA	FASTA	224	23,239
	10 20 30 40 50 60 MQKTSILIVA LVALFAITEA LPSLPTTGPI RVRRQVLGGS LTSNPAGGAD ARLDLTKGIG 70 80 90 100 110 120 NPNHNVVGQV FAAGNTQSGP VTTGGTLAYN NAGHGASLTK THTPGVKDVF QQEAHANLFN 130 140 150 160 170 180 NGRHNLDAKV FASQNKLANG FEFQRNGAGL DYSHINGHGA SLTHSNFPGI GQQLGLDGRA 190 200 210 220 NLWSSPNRAT TLDLTGSASK WTSGPFANQK PNFGAGLGLS HHFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteins." Aasling B., Dushay M.S., Hultmark D. Insect Biochem. Mol. Biol. 25:511-518(1995) [PubMed: 7742836] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[2]	"Two attacin antibacterial genes of Drosophila melanogaster." Dushay M.S., Roethele J.B., Chaverri J.M., Dulek D.E., Syed S.K., Kitami T., Eldon E.D. Gene 246:49-57(2000) [PubMed: 10767526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z46893 Genomic DNA. Translation: CAA86995.1. AF220544 Genomic DNA. Translation: AAF70455.1. AE013599 Genomic DNA. Translation: AAF58215.1.
RefSeq	NP_523745.1.
UniGene	Dm.3981
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P45884. 9 interactions.
Proteomic databases
PRIDE	P45884.
Genome annotation databases
Ensembl	FBgn0012042. Drosophila melanogaster. [Contig view]
GeneID	36636.
KEGG	dme:Dmel_CG10146.
Organism-specific databases
FlyBase	FBgn0012042. AttA.
Phylogenomic databases
HOGENOM	P45884.
Gene expression databases
GermOnline	CG10146. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005521. Attacin_C. IPR005520. Attacin_N. [Graphical view]
Pfam	PF03769. Attacin_C. 1 hit. PF03768. Attacin_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	799616.

Entry information

Entry name

ATTA_DROME

Accession

Primary (citable) accession number: P45884
Secondary accession number(s): Q9V750

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project