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Protein

Acyl-CoA-binding protein homolog

Gene
N/A
Organism
Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play important functions in the control of brain and pituitary activities. May regulate GABA neurotransmission through a paracrine and/or autocrine mechanism. May not bind acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Acyl-CoABy similarity1
Binding sitei52Acyl-CoABy similarity1
Binding sitei56Acyl-CoABy similarity1
Binding sitei75Acyl-CoABy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein homolog
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor homolog
Short name:
DBI
OrganismiPelophylax ridibundus (Marsh frog) (Rana ridibunda)
Taxonomic identifieri8406 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002140092 – 88Acyl-CoA-binding protein homologAdd BLAST87

Expressioni

Tissue specificityi

Brain. Is selectively expressed in glial cells.

Structurei

3D structure databases

ProteinModelPortaliP45883.
SMRiP45883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 88ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 34Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

HOVERGENiHBG000398.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiView protein in InterPro
IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR035984. Acyl-CoA-binding_sf.
IPR014352. FERM/acyl-CoA-bd_prot_sf.
PfamiView protein in Pfam
PF00887. ACBP. 1 hit.
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiView protein in PROSITE
PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQADFDKA AGDVKKLKTK PTDDELKELY GLYKQSTVGD INIECPGMLD
60 70 80
LKGKAKWDAW NLKKGLSKED AMSAYVSKAH ELIEKYGL
Length:88
Mass (Da):9,808
Last modified:January 23, 2007 - v2
Checksum:i4B2BCA61E8BD54C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09205 mRNA. Translation: AAB60606.1.
PIRiA57711.

Similar proteinsi

Entry informationi

Entry nameiACBP_PELRI
AccessioniPrimary (citable) accession number: P45883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: January 31, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families