##gff-version 3 P45880 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:25944712;Dbxref=PMID:19413330,PMID:25944712 P45880 UniProtKB Chain 2 294 . . . ID=PRO_0000050505;Note=Voltage-dependent anion-selective channel protein 2 P45880 UniProtKB Transmembrane 37 46 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 50 58 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 65 75 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 80 87 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 91 100 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 106 115 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 122 131 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 134 141 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 148 156 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 161 169 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 174 186 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 189 196 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 200 209 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 213 222 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 229 238 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 242 249 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 253 262 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 265 274 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Transmembrane 284 293 . . . Note=Beta stranded;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Binding site 253 255 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Binding site 271 275 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Site 84 84 . . . Note=Involved in ceramide and phosphatidylcholine binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31015432;Dbxref=PMID:31015432 P45880 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:25944712;Dbxref=PMID:19413330,PMID:25944712 P45880 UniProtKB Modified residue 31 31 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P45880 UniProtKB Modified residue 31 31 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60930 P45880 UniProtKB Modified residue 78 78 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60932 P45880 UniProtKB Modified residue 118 118 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Modified residue 120 120 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60930 P45880 UniProtKB Modified residue 251 251 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Modified residue 277 277 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Cross-link 31 31 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 64 64 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 72 72 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 120 120 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 121 121 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 124 124 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 172 172 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P21796 P45880 UniProtKB Cross-link 277 277 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Cross-link 285 285 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25621951;Dbxref=PMID:25621951 P45880 UniProtKB Alternative sequence 1 11 . . . ID=VSP_005077;Note=In isoform 1. MATHGQTCARP->MSWCNELRLPALKQHSIGRGLESHIT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:7685033;Dbxref=PMID:7685033 P45880 UniProtKB Alternative sequence 1 11 . . . ID=VSP_005076;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:7685033,ECO:0000303|Ref.4;Dbxref=PMID:7685033 P45880 UniProtKB Natural variant 24 24 . . . ID=VAR_006380;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8420959;Dbxref=PMID:8420959 P45880 UniProtKB Mutagenesis 84 84 . . . Note=Abolishes ceramide and phosphatidylcholine binding. Decreases apoptosis frequency following mitochondrial targeting of ceramide. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31015432;Dbxref=PMID:31015432