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Protein

Voltage-dependent anion-selective channel protein 2

Gene

VDAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei84 – 841Involved in hexokinase bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi253 – 2553NADBy similarity
Nucleotide bindingi271 – 2755NADBy similarity

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. porin activity Source: UniProtKB-KW
  3. voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  1. anion transport Source: ProtInc
  2. negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  3. negative regulation of protein polymerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

NAD, Nucleotide-binding

Protein family/group databases

TCDBi1.B.8.1.12. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 2
Short name:
VDAC-2
Short name:
hVDAC2
Alternative name(s):
Outer mitochondrial membrane protein porin 2
Gene namesi
Name:VDAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:12672. VDAC2.

Subcellular locationi

Mitochondrion outer membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 4610Beta strandedBy similarity
Transmembranei50 – 589Beta strandedBy similarity
Transmembranei65 – 7511Beta strandedBy similarityAdd
BLAST
Transmembranei80 – 878Beta strandedBy similarity
Transmembranei91 – 10010Beta strandedBy similarity
Transmembranei106 – 11510Beta strandedBy similarity
Transmembranei122 – 13110Beta strandedBy similarity
Transmembranei134 – 1418Beta strandedBy similarity
Transmembranei148 – 1569Beta strandedBy similarity
Transmembranei161 – 1699Beta strandedBy similarity
Transmembranei174 – 18613Beta strandedBy similarityAdd
BLAST
Transmembranei189 – 1968Beta strandedBy similarity
Transmembranei200 – 20910Beta strandedBy similarity
Transmembranei213 – 22210Beta strandedBy similarity
Transmembranei229 – 23810Beta strandedBy similarity
Transmembranei242 – 2498Beta strandedBy similarity
Transmembranei253 – 26210Beta strandedBy similarity
Transmembranei265 – 27410Beta strandedBy similarity
Transmembranei284 – 29310Beta strandedBy similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. mitochondrial inner membrane Source: Ensembl
  3. mitochondrial nucleoid Source: BHF-UCL
  4. mitochondrial outer membrane Source: ProtInc
  5. mitochondrion Source: UniProtKB
  6. nucleus Source: UniProtKB
  7. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 294293Voltage-dependent anion-selective channel protein 2PRO_0000050505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei31 – 311N6-acetyllysine; alternate1 Publication
Modified residuei31 – 311N6-succinyllysine; alternateBy similarity
Cross-linki31 – 31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki64 – 64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki72 – 72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei120 – 1201N6-acetyllysineBy similarity
Cross-linki120 – 120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki121 – 121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki124 – 124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki277 – 277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki285 – 285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP45880.
PaxDbiP45880.
PRIDEiP45880.

2D gel databases

DOSAC-COBS-2DPAGEP45880.
OGPiP45880.
REPRODUCTION-2DPAGEP45880.
SWISS-2DPAGEP45880.
UCD-2DPAGEP45880.

PTM databases

PhosphoSiteiP45880.

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

BgeeiP45880.
CleanExiHS_VDAC2.
ExpressionAtlasiP45880. baseline.
GenevestigatoriP45880.

Organism-specific databases

HPAiHPA043475.

Interactioni

Subunit structurei

Interacts with hexokinases.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM162AQ96A262EBI-354022,EBI-6123466

Protein-protein interaction databases

BioGridi113260. 53 interactions.
IntActiP45880. 19 interactions.
MINTiMINT-3016132.
STRINGi9606.ENSP00000361686.

Structurei

3D structure databases

ProteinModelPortaliP45880.
SMRiP45880. Positions 12-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiNOG243169.
GeneTreeiENSGT00390000011336.
HOVERGENiHBG054036.
InParanoidiP45880.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG7P8P8G.
PhylomeDBiP45880.
TreeFamiTF315091.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030277. VDAC2.
[Graphical view]
PANTHERiPTHR11743:SF12. PTHR11743:SF12. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P45880-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV
60 70 80 90 100
EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED
110 120 130 140 150
QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH
160 170 180 190 200
GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE
210 220 230 240 250
FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN
260 270 280 290
SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA
Length:294
Mass (Da):31,567
Last modified:September 10, 2007 - v2
Checksum:iF4EAE732E653637E
GO
Isoform 1 (identifier: P45880-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MATHGQTCARP → MSWCNELRLPALKQHSIGRGLESHIT

Show »
Length:309
Mass (Da):33,372
Checksum:i7A94C18F1C07DEBA
GO
Isoform 2 (identifier: P45880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:283
Mass (Da):30,412
Checksum:i9A66CDF9CF0542B9
GO

Sequence cautioni

Isoform 1 : The sequence AAA60144.1 differs from that shown. Reason: Frameshift at position 303. Curated
Isoform 2 : The sequence AAA60145.1 differs from that shown. Reason: Frameshift at position 277. Curated
The sequence CAH73106.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40910.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241A → V.1 Publication
VAR_006380

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111MATHGQTCARP → MSWCNELRLPALKQHSIGRG LESHIT in isoform 1. 1 PublicationVSP_005077Add
BLAST
Alternative sequencei1 – 1111Missing in isoform 2. 2 PublicationsVSP_005076Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08666 mRNA. Translation: AAA60144.1. Frameshift.
L08666 mRNA. Translation: AAA60145.1. Frameshift.
L06328 mRNA. Translation: AAB59457.1.
AF152227
, AF152220, AF152221, AF152222, AF152223, AF152224, AF152225, AF152226 Genomic DNA. Translation: AAD40241.1.
CR456964 mRNA. Translation: CAG33245.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73108.1.
AL392111, AL390034 Genomic DNA. Translation: CAI40914.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73107.1.
AL392111, AL390034 Genomic DNA. Translation: CAI40911.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73106.1. Sequence problems.
AL392111, AL390034 Genomic DNA. Translation: CAI40910.1. Sequence problems.
BC000165 mRNA. Translation: AAH00165.2.
BC012883 mRNA. Translation: AAH12883.2.
BC072407 mRNA. Translation: AAH72407.1.
CCDSiCCDS53544.1. [P45880-1]
CCDS7348.1. [P45880-3]
PIRiA45972.
B44422.
RefSeqiNP_001171712.1. NM_001184783.1. [P45880-1]
NP_001171752.1. NM_001184823.1. [P45880-3]
NP_003366.2. NM_003375.3. [P45880-3]
XP_006718024.1. XM_006717961.1. [P45880-3]
UniGeneiHs.355927.

Genome annotation databases

EnsembliENST00000313132; ENSP00000361635; ENSG00000165637. [P45880-1]
ENST00000332211; ENSP00000361686; ENSG00000165637. [P45880-3]
ENST00000543351; ENSP00000443092; ENSG00000165637. [P45880-3]
GeneIDi7417.
KEGGihsa:7417.
UCSCiuc001jwz.3. human. [P45880-3]
uc001jxa.3. human. [P45880-1]

Polymorphism databases

DMDMi158518391.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08666 mRNA. Translation: AAA60144.1. Frameshift.
L08666 mRNA. Translation: AAA60145.1. Frameshift.
L06328 mRNA. Translation: AAB59457.1.
AF152227
, AF152220, AF152221, AF152222, AF152223, AF152224, AF152225, AF152226 Genomic DNA. Translation: AAD40241.1.
CR456964 mRNA. Translation: CAG33245.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73108.1.
AL392111, AL390034 Genomic DNA. Translation: CAI40914.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73107.1.
AL392111, AL390034 Genomic DNA. Translation: CAI40911.1.
AL390034, AL392111 Genomic DNA. Translation: CAH73106.1. Sequence problems.
AL392111, AL390034 Genomic DNA. Translation: CAI40910.1. Sequence problems.
BC000165 mRNA. Translation: AAH00165.2.
BC012883 mRNA. Translation: AAH12883.2.
BC072407 mRNA. Translation: AAH72407.1.
CCDSiCCDS53544.1. [P45880-1]
CCDS7348.1. [P45880-3]
PIRiA45972.
B44422.
RefSeqiNP_001171712.1. NM_001184783.1. [P45880-1]
NP_001171752.1. NM_001184823.1. [P45880-3]
NP_003366.2. NM_003375.3. [P45880-3]
XP_006718024.1. XM_006717961.1. [P45880-3]
UniGeneiHs.355927.

3D structure databases

ProteinModelPortaliP45880.
SMRiP45880. Positions 12-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113260. 53 interactions.
IntActiP45880. 19 interactions.
MINTiMINT-3016132.
STRINGi9606.ENSP00000361686.

Chemistry

BindingDBiP45880.
ChEMBLiCHEMBL6190.
DrugBankiDB01375. Dihydroxyaluminium.

Protein family/group databases

TCDBi1.B.8.1.12. the mitochondrial and plastid porin (mpp) family.

PTM databases

PhosphoSiteiP45880.

Polymorphism databases

DMDMi158518391.

2D gel databases

DOSAC-COBS-2DPAGEP45880.
OGPiP45880.
REPRODUCTION-2DPAGEP45880.
SWISS-2DPAGEP45880.
UCD-2DPAGEP45880.

Proteomic databases

MaxQBiP45880.
PaxDbiP45880.
PRIDEiP45880.

Protocols and materials databases

DNASUi7417.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313132; ENSP00000361635; ENSG00000165637. [P45880-1]
ENST00000332211; ENSP00000361686; ENSG00000165637. [P45880-3]
ENST00000543351; ENSP00000443092; ENSG00000165637. [P45880-3]
GeneIDi7417.
KEGGihsa:7417.
UCSCiuc001jwz.3. human. [P45880-3]
uc001jxa.3. human. [P45880-1]

Organism-specific databases

CTDi7417.
GeneCardsiGC10P076969.
H-InvDBHIX0029994.
HGNCiHGNC:12672. VDAC2.
HPAiHPA043475.
MIMi193245. gene.
neXtProtiNX_P45880.
PharmGKBiPA37295.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG243169.
GeneTreeiENSGT00390000011336.
HOVERGENiHBG054036.
InParanoidiP45880.
KOiK15040.
OMAiMCVPPSY.
OrthoDBiEOG7P8P8G.
PhylomeDBiP45880.
TreeFamiTF315091.

Miscellaneous databases

GeneWikiiVDAC2.
GenomeRNAii7417.
NextBioi29042.
PROiP45880.
SOURCEiSearch...

Gene expression databases

BgeeiP45880.
CleanExiHS_VDAC2.
ExpressionAtlasiP45880. baseline.
GenevestigatoriP45880.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
IPR030277. VDAC2.
[Graphical view]
PANTHERiPTHR11743:SF12. PTHR11743:SF12. 1 hit.
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PRINTSiPR00185. EUKARYTPORIN.
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mitochondrial porin cDNA predicts the existence of multiple human porins."
    Ha H., Hajek P., Bedwell D.M., Burrows P.D.
    J. Biol. Chem. 268:12143-12149(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: B-cell.
  2. "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
    Blachly-Dyson E., Zambronicz E.B., Yu W.H., Adams V., McCabe E.R., Adelman J.P., Colombini M., Forte M.A.
    J. Biol. Chem. 268:1835-1841(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-24.
    Tissue: Liver.
  3. "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
    Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
    Mamm. Genome 10:1041-1042(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Cervix and Eye.
  7. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (NOV-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 86-120; 178-229 AND 248-267, IDENTIFICATION BY IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  8. Bienvenut W.V.
    Submitted (MAY-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 11-23 (ISOFORM 3), PROTEIN SEQUENCE OF 46-64; 75-85; 108-120; 178-185; 236-263 AND 268-277 (ISOFORMS 1/2/3), IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  9. "Subcellular localization of human voltage-dependent anion channel isoforms."
    Yu W.H., Wolfgang W., Forte M.A.
    J. Biol. Chem. 270:13998-14006(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  20. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."
    Cunningham C.N., Baughman J.M., Phu L., Tea J.S., Yu C., Coons M., Kirkpatrick D.S., Bingol B., Corn J.E.
    Nat. Cell Biol. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-31; LYS-64; LYS-72; LYS-120; LYS-121; LYS-124; LYS-277 AND LYS-285.

Entry informationi

Entry nameiVDAC2_HUMAN
AccessioniPrimary (citable) accession number: P45880
Secondary accession number(s): Q5VWK1
, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: September 10, 2007
Last modified: March 31, 2015
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.