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P45880

- VDAC2_HUMAN

UniProt

P45880 - VDAC2_HUMAN

Protein

Voltage-dependent anion-selective channel protein 2

Gene

VDAC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei84 – 841Involved in hexokinase bindingBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi253 – 2553NADBy similarity
    Nucleotide bindingi271 – 2755NADBy similarity

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. porin activity Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. voltage-gated anion channel activity Source: UniProtKB

    GO - Biological processi

    1. anion transport Source: ProtInc
    2. negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    3. negative regulation of protein polymerization Source: Ensembl

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    NAD, Nucleotide-binding

    Protein family/group databases

    TCDBi1.B.8.1.12. the mitochondrial and plastid porin (mpp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent anion-selective channel protein 2
    Short name:
    VDAC-2
    Short name:
    hVDAC2
    Alternative name(s):
    Outer mitochondrial membrane protein porin 2
    Gene namesi
    Name:VDAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12672. VDAC2.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial inner membrane Source: Ensembl
    3. mitochondrial nucleoid Source: BHF-UCL
    4. mitochondrial outer membrane Source: ProtInc
    5. mitochondrion Source: UniProt
    6. nucleus Source: UniProt
    7. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37295.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 294293Voltage-dependent anion-selective channel protein 2PRO_0000050505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei31 – 311N6-acetyllysine; alternate1 Publication
    Modified residuei31 – 311N6-succinyllysine; alternateBy similarity
    Modified residuei120 – 1201N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP45880.
    PaxDbiP45880.
    PRIDEiP45880.

    2D gel databases

    DOSAC-COBS-2DPAGEP45880.
    OGPiP45880.
    REPRODUCTION-2DPAGEP45880.
    SWISS-2DPAGEP45880.
    UCD-2DPAGEP45880.

    PTM databases

    PhosphoSiteiP45880.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined.

    Gene expression databases

    BgeeiP45880.
    CleanExiHS_VDAC2.
    GenevestigatoriP45880.

    Organism-specific databases

    HPAiHPA043475.

    Interactioni

    Subunit structurei

    Interacts with hexokinases.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FAM162AQ96A262EBI-354022,EBI-6123466

    Protein-protein interaction databases

    BioGridi113260. 53 interactions.
    IntActiP45880. 17 interactions.
    MINTiMINT-3016132.
    STRINGi9606.ENSP00000361686.

    Structurei

    3D structure databases

    ProteinModelPortaliP45880.
    SMRiP45880. Positions 12-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 4610Beta strandedBy similarity
    Transmembranei50 – 589Beta strandedBy similarity
    Transmembranei65 – 7511Beta strandedBy similarityAdd
    BLAST
    Transmembranei80 – 878Beta strandedBy similarity
    Transmembranei91 – 10010Beta strandedBy similarity
    Transmembranei106 – 11510Beta strandedBy similarity
    Transmembranei122 – 13110Beta strandedBy similarity
    Transmembranei134 – 1418Beta strandedBy similarity
    Transmembranei148 – 1569Beta strandedBy similarity
    Transmembranei161 – 1699Beta strandedBy similarity
    Transmembranei174 – 18613Beta strandedBy similarityAdd
    BLAST
    Transmembranei189 – 1968Beta strandedBy similarity
    Transmembranei200 – 20910Beta strandedBy similarity
    Transmembranei213 – 22210Beta strandedBy similarity
    Transmembranei229 – 23810Beta strandedBy similarity
    Transmembranei242 – 2498Beta strandedBy similarity
    Transmembranei253 – 26210Beta strandedBy similarity
    Transmembranei265 – 27410Beta strandedBy similarity
    Transmembranei284 – 29310Beta strandedBy similarity

    Family & Domainsi

    Domaini

    Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiNOG243169.
    HOVERGENiHBG054036.
    KOiK15040.
    OMAiTGKVNGS.
    OrthoDBiEOG7P8P8G.
    PhylomeDBiP45880.
    TreeFamiTF315091.

    Family and domain databases

    Gene3Di2.40.160.10. 1 hit.
    InterProiIPR023614. Porin_dom.
    IPR001925. Porin_Euk.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view]
    PfamiPF01459. Porin_3. 1 hit.
    [Graphical view]
    PRINTSiPR00185. EUKARYTPORIN.
    PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: P45880-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV    50
    EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED 100
    QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH 150
    GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE 200
    FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN 250
    SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA 294
    Length:294
    Mass (Da):31,567
    Last modified:September 11, 2007 - v2
    Checksum:iF4EAE732E653637E
    GO
    Isoform 1 (identifier: P45880-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: MATHGQTCARP → MSWCNELRLPALKQHSIGRGLESHIT

    Show »
    Length:309
    Mass (Da):33,372
    Checksum:i7A94C18F1C07DEBA
    GO
    Isoform 2 (identifier: P45880-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:283
    Mass (Da):30,412
    Checksum:i9A66CDF9CF0542B9
    GO

    Sequence cautioni

    Isoform 1 : The sequence AAA60144.1 differs from that shown. Reason: Frameshift at position 303.
    Isoform 2 : The sequence AAA60145.1 differs from that shown. Reason: Frameshift at position 277.
    The sequence CAH73106.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40910.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241A → V.1 Publication
    VAR_006380

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111MATHGQTCARP → MSWCNELRLPALKQHSIGRG LESHIT in isoform 1. 1 PublicationVSP_005077Add
    BLAST
    Alternative sequencei1 – 1111Missing in isoform 2. 2 PublicationsVSP_005076Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08666 mRNA. Translation: AAA60144.1. Frameshift.
    L08666 mRNA. Translation: AAA60145.1. Frameshift.
    L06328 mRNA. Translation: AAB59457.1.
    AF152227
    , AF152220, AF152221, AF152222, AF152223, AF152224, AF152225, AF152226 Genomic DNA. Translation: AAD40241.1.
    CR456964 mRNA. Translation: CAG33245.1.
    AL390034, AL392111 Genomic DNA. Translation: CAH73108.1.
    AL392111, AL390034 Genomic DNA. Translation: CAI40914.1.
    AL390034, AL392111 Genomic DNA. Translation: CAH73107.1.
    AL392111, AL390034 Genomic DNA. Translation: CAI40911.1.
    AL390034, AL392111 Genomic DNA. Translation: CAH73106.1. Sequence problems.
    AL392111, AL390034 Genomic DNA. Translation: CAI40910.1. Sequence problems.
    BC000165 mRNA. Translation: AAH00165.2.
    BC012883 mRNA. Translation: AAH12883.2.
    BC072407 mRNA. Translation: AAH72407.1.
    CCDSiCCDS53544.1. [P45880-1]
    CCDS7348.1. [P45880-3]
    PIRiA45972.
    B44422.
    RefSeqiNP_001171712.1. NM_001184783.1. [P45880-1]
    NP_001171752.1. NM_001184823.1. [P45880-3]
    NP_003366.2. NM_003375.3. [P45880-3]
    XP_006718024.1. XM_006717961.1. [P45880-3]
    UniGeneiHs.355927.

    Genome annotation databases

    EnsembliENST00000313132; ENSP00000361635; ENSG00000165637. [P45880-1]
    ENST00000332211; ENSP00000361686; ENSG00000165637. [P45880-3]
    ENST00000543351; ENSP00000443092; ENSG00000165637. [P45880-3]
    GeneIDi7417.
    KEGGihsa:7417.
    UCSCiuc001jwz.3. human. [P45880-3]
    uc001jxa.3. human. [P45880-1]

    Polymorphism databases

    DMDMi158518391.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08666 mRNA. Translation: AAA60144.1 . Frameshift.
    L08666 mRNA. Translation: AAA60145.1 . Frameshift.
    L06328 mRNA. Translation: AAB59457.1 .
    AF152227
    , AF152220 , AF152221 , AF152222 , AF152223 , AF152224 , AF152225 , AF152226 Genomic DNA. Translation: AAD40241.1 .
    CR456964 mRNA. Translation: CAG33245.1 .
    AL390034 , AL392111 Genomic DNA. Translation: CAH73108.1 .
    AL392111 , AL390034 Genomic DNA. Translation: CAI40914.1 .
    AL390034 , AL392111 Genomic DNA. Translation: CAH73107.1 .
    AL392111 , AL390034 Genomic DNA. Translation: CAI40911.1 .
    AL390034 , AL392111 Genomic DNA. Translation: CAH73106.1 . Sequence problems.
    AL392111 , AL390034 Genomic DNA. Translation: CAI40910.1 . Sequence problems.
    BC000165 mRNA. Translation: AAH00165.2 .
    BC012883 mRNA. Translation: AAH12883.2 .
    BC072407 mRNA. Translation: AAH72407.1 .
    CCDSi CCDS53544.1. [P45880-1 ]
    CCDS7348.1. [P45880-3 ]
    PIRi A45972.
    B44422.
    RefSeqi NP_001171712.1. NM_001184783.1. [P45880-1 ]
    NP_001171752.1. NM_001184823.1. [P45880-3 ]
    NP_003366.2. NM_003375.3. [P45880-3 ]
    XP_006718024.1. XM_006717961.1. [P45880-3 ]
    UniGenei Hs.355927.

    3D structure databases

    ProteinModelPortali P45880.
    SMRi P45880. Positions 12-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113260. 53 interactions.
    IntActi P45880. 17 interactions.
    MINTi MINT-3016132.
    STRINGi 9606.ENSP00000361686.

    Chemistry

    ChEMBLi CHEMBL6190.
    DrugBanki DB01375. Dihydroxyaluminium.

    Protein family/group databases

    TCDBi 1.B.8.1.12. the mitochondrial and plastid porin (mpp) family.

    PTM databases

    PhosphoSitei P45880.

    Polymorphism databases

    DMDMi 158518391.

    2D gel databases

    DOSAC-COBS-2DPAGE P45880.
    OGPi P45880.
    REPRODUCTION-2DPAGE P45880.
    SWISS-2DPAGE P45880.
    UCD-2DPAGE P45880.

    Proteomic databases

    MaxQBi P45880.
    PaxDbi P45880.
    PRIDEi P45880.

    Protocols and materials databases

    DNASUi 7417.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313132 ; ENSP00000361635 ; ENSG00000165637 . [P45880-1 ]
    ENST00000332211 ; ENSP00000361686 ; ENSG00000165637 . [P45880-3 ]
    ENST00000543351 ; ENSP00000443092 ; ENSG00000165637 . [P45880-3 ]
    GeneIDi 7417.
    KEGGi hsa:7417.
    UCSCi uc001jwz.3. human. [P45880-3 ]
    uc001jxa.3. human. [P45880-1 ]

    Organism-specific databases

    CTDi 7417.
    GeneCardsi GC10P076969.
    H-InvDB HIX0029994.
    HGNCi HGNC:12672. VDAC2.
    HPAi HPA043475.
    MIMi 193245. gene.
    neXtProti NX_P45880.
    PharmGKBi PA37295.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243169.
    HOVERGENi HBG054036.
    KOi K15040.
    OMAi TGKVNGS.
    OrthoDBi EOG7P8P8G.
    PhylomeDBi P45880.
    TreeFami TF315091.

    Miscellaneous databases

    GeneWikii VDAC2.
    GenomeRNAii 7417.
    NextBioi 29042.
    PROi P45880.
    SOURCEi Search...

    Gene expression databases

    Bgeei P45880.
    CleanExi HS_VDAC2.
    Genevestigatori P45880.

    Family and domain databases

    Gene3Di 2.40.160.10. 1 hit.
    InterProi IPR023614. Porin_dom.
    IPR001925. Porin_Euk.
    IPR027246. Porin_Euk/Tom40.
    [Graphical view ]
    Pfami PF01459. Porin_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00185. EUKARYTPORIN.
    PROSITEi PS00558. EUKARYOTIC_PORIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mitochondrial porin cDNA predicts the existence of multiple human porins."
      Ha H., Hajek P., Bedwell D.M., Burrows P.D.
      J. Biol. Chem. 268:12143-12149(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: B-cell.
    2. "Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
      Blachly-Dyson E., Zambronicz E.B., Yu W.H., Adams V., McCabe E.R., Adelman J.P., Colombini M., Forte M.A.
      J. Biol. Chem. 268:1835-1841(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT VAL-24.
      Tissue: Liver.
    3. "Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
      Decker W.K., Bowles K.R., Schatte E.C., Towbin J.A., Craigen W.J.
      Mamm. Genome 10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Cervix and Eye.
    7. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 86-120; 178-229 AND 248-267, IDENTIFICATION BY IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
    8. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 11-23 (ISOFORM 3), PROTEIN SEQUENCE OF 46-64; 75-85; 108-120; 178-185; 236-263 AND 268-277 (ISOFORMS 1/2/3), IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    9. "Subcellular localization of human voltage-dependent anion channel isoforms."
      Yu W.H., Wolfgang W., Forte M.A.
      J. Biol. Chem. 270:13998-14006(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVDAC2_HUMAN
    AccessioniPrimary (citable) accession number: P45880
    Secondary accession number(s): Q5VWK1
    , Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3