Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

Fkbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:Fkbp2
Synonyms:Fkbp13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95542. Fkbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 140118Peptidyl-prolyl cis-trans isomerase FKBP2PRO_0000025507Add
BLAST

Proteomic databases

EPDiP45878.
PaxDbiP45878.
PRIDEiP45878.

PTM databases

iPTMnetiP45878.
PhosphoSiteiP45878.

Expressioni

Gene expression databases

BgeeiP45878.
CleanExiMM_FKBP2.
ExpressionAtlasiP45878. baseline and differential.
GenevisibleiP45878. MM.

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Protein-protein interaction databases

IntActiP45878. 5 interactions.
MINTiMINT-4996748.
STRINGi10090.ENSMUSP00000066839.

Structurei

3D structure databases

ProteinModelPortaliP45878.
SMRiP45878. Positions 41-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 13589PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi137 – 1404Prevents secretion from ERSequence analysis

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP45878.
KOiK09569.
OMAiNCTRKAK.
OrthoDBiEOG7T1R9S.
PhylomeDBiP45878.
TreeFamiTF105292.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSWILTIL SICLSALAAA TGAEGKRKLQ IGVKKRVDHC PIKSRKGDVL
60 70 80 90 100
HMHYTGKLED GTEFDSSLPQ NQPFVFSLGT GQVIKGWDQG LLGMCEGEKR
110 120 130 140
KLVIPSELGY GERGAPPKIP GGATLVFEVE LLKIERRSEL
Length:140
Mass (Da):15,344
Last modified:November 1, 1995 - v1
Checksum:iF4E7FCC7766A0416
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77831 Genomic DNA. Translation: AAA37631.1.
BC031824 mRNA. Translation: AAH31824.1.
BC053692 mRNA. Translation: AAH53692.1.
CCDSiCCDS29515.1.
PIRiI49668.
RefSeqiNP_001159840.1. NM_001166368.1.
NP_032046.1. NM_008020.3.
XP_006526736.1. XM_006526673.1.
XP_006526737.1. XM_006526674.1.
XP_006526738.1. XM_006526675.2.
UniGeneiMm.4234.

Genome annotation databases

EnsembliENSMUST00000070878; ENSMUSP00000066839; ENSMUSG00000056629.
ENSMUST00000177752; ENSMUSP00000136438; ENSMUSG00000056629.
GeneIDi14227.
KEGGimmu:14227.
UCSCiuc008gjt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77831 Genomic DNA. Translation: AAA37631.1.
BC031824 mRNA. Translation: AAH31824.1.
BC053692 mRNA. Translation: AAH53692.1.
CCDSiCCDS29515.1.
PIRiI49668.
RefSeqiNP_001159840.1. NM_001166368.1.
NP_032046.1. NM_008020.3.
XP_006526736.1. XM_006526673.1.
XP_006526737.1. XM_006526674.1.
XP_006526738.1. XM_006526675.2.
UniGeneiMm.4234.

3D structure databases

ProteinModelPortaliP45878.
SMRiP45878. Positions 41-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP45878. 5 interactions.
MINTiMINT-4996748.
STRINGi10090.ENSMUSP00000066839.

PTM databases

iPTMnetiP45878.
PhosphoSiteiP45878.

Proteomic databases

EPDiP45878.
PaxDbiP45878.
PRIDEiP45878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070878; ENSMUSP00000066839; ENSMUSG00000056629.
ENSMUST00000177752; ENSMUSP00000136438; ENSMUSG00000056629.
GeneIDi14227.
KEGGimmu:14227.
UCSCiuc008gjt.2. mouse.

Organism-specific databases

CTDi2286.
MGIiMGI:95542. Fkbp2.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP45878.
KOiK09569.
OMAiNCTRKAK.
OrthoDBiEOG7T1R9S.
PhylomeDBiP45878.
TreeFamiTF105292.

Miscellaneous databases

ChiTaRSiFkbp2. mouse.
PROiP45878.
SOURCEiSearch...

Gene expression databases

BgeeiP45878.
CleanExiMM_FKBP2.
ExpressionAtlasiP45878. baseline and differential.
GenevisibleiP45878. MM.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1."
    Hendrickson B.A., Zhang W., Craig R.J., Jin Y.J., Bierer R.E., Burakoff S.J., Dilella A.G.
    Gene 134:271-275(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Liver.
  3. "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1."
    Walensky L.D., Gascard P., Fields M.E., Blackshaw S., Conboy J.G., Mohandas N., Snyder S.H.
    J. Cell Biol. 141:143-153(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EPB41L2.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiFKBP2_MOUSE
AccessioniPrimary (citable) accession number: P45878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.