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Protein

Peptidyl-prolyl cis-trans isomerase C

Gene

PPIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Cyclosporin A (CsA) inhibits CYPC.

GO - Molecular functioni

  • cyclosporin A binding Source: UniProtKB
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Cyclosporin

Enzyme and pathway databases

BioCyciZFISH:HS09855-MONOMER.
BRENDAi5.2.1.8. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase C (EC:5.2.1.8)
Short name:
PPIase C
Alternative name(s):
Cyclophilin C
Rotamase C
Gene namesi
Name:PPIC
Synonyms:CYPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:9256. PPIC.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5480.
OpenTargetsiENSG00000168938.
PharmGKBiPA33581.

Chemistry databases

ChEMBLiCHEMBL2424505.
DrugBankiDB00172. L-Proline.

Polymorphism and mutation databases

BioMutaiPPIC.
DMDMi1169178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641471 – 212Peptidyl-prolyl cis-trans isomerase CAdd BLAST212

Proteomic databases

EPDiP45877.
MaxQBiP45877.
PaxDbiP45877.
PeptideAtlasiP45877.
PRIDEiP45877.

PTM databases

iPTMnetiP45877.
PhosphoSitePlusiP45877.

Expressioni

Gene expression databases

BgeeiENSG00000168938.
CleanExiHS_PPIC.
GenevisibleiP45877. HS.

Organism-specific databases

HPAiHPA039163.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-953909,EBI-744695
SGTAO437655EBI-953909,EBI-347996
UBAP1Q9NZ093EBI-953909,EBI-9641159
UBQLN1Q9UMX03EBI-953909,EBI-741480
UBQLN1Q9UMX0-23EBI-953909,EBI-10173939

Protein-protein interaction databases

BioGridi111476. 9 interactors.
IntActiP45877. 7 interactors.
MINTiMINT-2861873.
STRINGi9606.ENSP00000303057.

Chemistry databases

BindingDBiP45877.

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 46Combined sources12
Beta strandi49 – 58Combined sources10
Turni60 – 62Combined sources3
Helixi64 – 75Combined sources12
Turni76 – 78Combined sources3
Beta strandi89 – 91Combined sources3
Turni92 – 94Combined sources3
Beta strandi95 – 98Combined sources4
Beta strandi102 – 107Combined sources6
Beta strandi131 – 134Combined sources4
Beta strandi136 – 138Combined sources3
Beta strandi146 – 151Combined sources6
Helixi154 – 156Combined sources3
Turni157 – 159Combined sources3
Beta strandi162 – 168Combined sources7
Helixi170 – 177Combined sources8
Beta strandi187 – 189Combined sources3
Beta strandi191 – 206Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ESLX-ray1.90A/B/C/D/E/F24-212[»]
ProteinModelPortaliP45877.
SMRiP45877.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45877.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 198PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST158

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP45877.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP45877.
TreeFamiTF354259.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGPRLLLP LVLCVGLGAL VFSSGAEGFR KRGPSVTAKV FFDVRIGDKD
60 70 80 90 100
VGRIVIGLFG KVVPKTVENF VALATGEKGY GYKGSKFHRV IKDFMIQGGD
110 120 130 140 150
ITTGDGTGGV SIYGETFPDE NFKLKHYGIG WVSMANAGPD TNGSQFFITL
160 170 180 190 200
TKPTWLDGKH VVFGKVIDGM TVVHSIELQA TDGHDRPLTN CSIINSGKID
210
VKTPFVVEIA DW
Length:212
Mass (Da):22,763
Last modified:November 1, 1995 - v1
Checksum:i6F3DB547A2AE581B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05177086K → R.1 PublicationCorresponds to variant rs34341374dbSNPEnsembl.1
Natural variantiVAR_060712160H → L.1 PublicationCorresponds to variant rs45560036dbSNPEnsembl.1
Natural variantiVAR_024319190N → S.1 PublicationCorresponds to variant rs451195dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S71018 mRNA. Translation: AAB31350.1.
EF506885 Genomic DNA. Translation: ABO43038.1.
CH471086 Genomic DNA. Translation: EAW48878.1.
BC002678 mRNA. Translation: AAH02678.1.
CCDSiCCDS4133.1.
PIRiA54204.
RefSeqiNP_000934.1. NM_000943.4.
UniGeneiHs.110364.

Genome annotation databases

EnsembliENST00000306442; ENSP00000303057; ENSG00000168938.
GeneIDi5480.
KEGGihsa:5480.
UCSCiuc003kth.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S71018 mRNA. Translation: AAB31350.1.
EF506885 Genomic DNA. Translation: ABO43038.1.
CH471086 Genomic DNA. Translation: EAW48878.1.
BC002678 mRNA. Translation: AAH02678.1.
CCDSiCCDS4133.1.
PIRiA54204.
RefSeqiNP_000934.1. NM_000943.4.
UniGeneiHs.110364.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ESLX-ray1.90A/B/C/D/E/F24-212[»]
ProteinModelPortaliP45877.
SMRiP45877.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111476. 9 interactors.
IntActiP45877. 7 interactors.
MINTiMINT-2861873.
STRINGi9606.ENSP00000303057.

Chemistry databases

BindingDBiP45877.
ChEMBLiCHEMBL2424505.
DrugBankiDB00172. L-Proline.

PTM databases

iPTMnetiP45877.
PhosphoSitePlusiP45877.

Polymorphism and mutation databases

BioMutaiPPIC.
DMDMi1169178.

Proteomic databases

EPDiP45877.
MaxQBiP45877.
PaxDbiP45877.
PeptideAtlasiP45877.
PRIDEiP45877.

Protocols and materials databases

DNASUi5480.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306442; ENSP00000303057; ENSG00000168938.
GeneIDi5480.
KEGGihsa:5480.
UCSCiuc003kth.4. human.

Organism-specific databases

CTDi5480.
DisGeNETi5480.
GeneCardsiPPIC.
HGNCiHGNC:9256. PPIC.
HPAiHPA039163.
MIMi123842. gene.
neXtProtiNX_P45877.
OpenTargetsiENSG00000168938.
PharmGKBiPA33581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0880. Eukaryota.
ENOG410Z0G4. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG001065.
InParanoidiP45877.
KOiK09563.
OMAiDRPLTNC.
OrthoDBiEOG091G0BGL.
PhylomeDBiP45877.
TreeFamiTF354259.

Enzyme and pathway databases

BioCyciZFISH:HS09855-MONOMER.
BRENDAi5.2.1.8. 2681.

Miscellaneous databases

ChiTaRSiPPIC. human.
EvolutionaryTraceiP45877.
GeneWikiiPPIC.
GenomeRNAii5480.
PROiP45877.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168938.
CleanExiHS_PPIC.
GenevisibleiP45877. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIC_HUMAN
AccessioniPrimary (citable) accession number: P45877
Secondary accession number(s): A4LBB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.