Reviewed, UniProtKB/Swiss-Prot P45857 (ACDB_BACSU)

Names and origin

Protein names

Recommended name:
    Acyl-CoA dehydrogenase
    EC=1.3.99.-

Gene names

Name:	mmgC
Synonyms:	yqiN
Ordered Locus Names:	BSU24150

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.
Cofactor	FAD By similarity.
Developmental stage	Expressed in the mother cell at intermediate stages of sporulation under the control of the sigma-E factor. Ref.1
Induction	Subject to catabolite repression. Ref.1
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Biological process	Sporulation
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Acyl-CoA dehydrogenase		PRO_0000201183
Experimental info
	Sequence conflict	97	1	L → M in AAB09615. Ref.1
	Sequence conflict	171	1	A → D in AAB09615. Ref.1
	Sequence conflict	329	1	Missing in BAA12589. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P45857-1 [UniParc]. Last modified July 7, 2009. Version 3. Checksum: 842FA980747D6C20	FASTA	379	40,941
	10 20 30 40 50 60 MHVTQEQVMM RKMVRDFARK EIAPAAEIME KTDEFPFQLI KKMGKHGLMG IPVPEQYGGA 70 80 90 100 110 120 GADVVSYILA IHEISRISAA VGVILSVHTS VGTNPILYFG NEEQKMKYIP NLASGDHLGA 130 140 150 160 170 180 FALTEPHSGS DAGSLRTTAI KKNGKYLLNG SKIFITNGGA ADIYITFALT APDQGRHGIS 190 200 210 220 230 240 AFIVEKNTPG FTVGKKERKL GLYGSNTTEL IFDNAEVPEA NLLGKEGDGF HIAMANLNVG 250 260 270 280 290 300 RIGIAAQALG IAEAALEHAV DYAKQRVQFG RPIAANQGIS FKLADMATRA EAARHLVYHA 310 320 330 340 350 360 ADLHNRGLNC GKEASMAKQF ASDAAVKAAL DAVQIYGGYG YMKDYPVERL LRDAKVTQIY 370 EGTNEIQRLI ISKYLLGGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis." Bryan E.M., Beall B.W., Moran C.P. Jr. J. Bacteriol. 178:4778-4786(1996) [PubMed: 8759838] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, INDUCTION. Strain: 168 / MB24.
[2]	"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes." Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y. Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / JH642.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 329.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U29084 Genomic DNA. Translation: AAB09615.1. D84432 Genomic DNA. Translation: BAA12589.1. AL009126 Genomic DNA. Translation: CAB14346.2.
PIR	D69658.
RefSeq	NP_390295.1.
3D structure databases
HSSP	HSSP built from PDB template 1BUC based on UniProtKB Q06319.
ModBase	Search...
Genome annotation databases
GeneID	938664.
GenomeReviews	Gene locus BSU24150 in contig AL009126_GR.
KEGG	bsu:BSU24150.
NMPDR	fig|224308.1.peg.2419.
Organism-specific databases
SubtiList	BG11321. mmgC. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P45857.
OMA	P45857. ILAIHEI.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU2413-MON.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACDB_BACSU

Accession

Primary (citable) accession number: P45857

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 7, 2009
Last modified:	July 7, 2009
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)