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P45844 (ABCG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene names
Name:ABCG1
Synonyms:ABC8, WHT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Ref.9 Ref.10

Subunit structure

May form heterodimers with several heterologous partners of the ABCG subfamily.

Subcellular location

Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. Ref.14

Tissue specificity

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. Ref.13

Induction

Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202. Ref.9 Ref.10 Ref.11

Post-translational modification

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. Ref.15

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells (Ref.14).

Sequence similarities

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]

Contains 1 ABC transmembrane type-2 domain.

Contains 1 ABC transporter domain.

Sequence caution

The sequence AAC51098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAK28841.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA95530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB13728.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA62631.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAC00730.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Cellular componentEndoplasmic reticulum
Golgi apparatus
Membrane
Mitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processamyloid precursor protein catabolic process

Inferred from direct assay PubMed 17293612. Source: BHF-UCL

cholesterol efflux

Inferred from direct assay PubMed 15994327. Source: BHF-UCL

cholesterol homeostasis

Inferred from direct assay PubMed 15994327. Source: BHF-UCL

cholesterol metabolic process

Inferred from direct assay PubMed 15994327. Source: BHF-UCL

detection of hormone stimulus

Non-traceable author statement Ref.5. Source: UniProtKB

glycoprotein transport

Inferred from direct assay PubMed 17293612. Source: BHF-UCL

high-density lipoprotein particle remodeling

Inferred from sequence or structural similarity PubMed 16556852. Source: BHF-UCL

intracellular cholesterol transport

Inferred from mutant phenotype PubMed 15994327. Source: BHF-UCL

lipoprotein metabolic process

Traceable author statement. Source: Reactome

low-density lipoprotein particle remodeling

Inferred from sequence or structural similarity PubMed 16556852. Source: BHF-UCL

negative regulation of cholesterol storage

Traceable author statement PubMed 18490524. Source: BHF-UCL

negative regulation of macrophage derived foam cell differentiation

Traceable author statement PubMed 18490524. Source: BHF-UCL

phospholipid efflux

Inferred from mutant phenotype PubMed 16702602. Source: BHF-UCL

phospholipid homeostasis

Inferred from mutant phenotype PubMed 16702602. Source: BHF-UCL

positive regulation of cholesterol biosynthetic process

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cholesterol efflux

Inferred from electronic annotation. Source: Ensembl

regulation of cholesterol esterification

Inferred from sequence or structural similarity PubMed 16556852. Source: BHF-UCL

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: BHF-UCL

response to high density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

response to lipid

Inferred from direct assay PubMed 16556852. Source: BHF-UCL

response to organic substance

Inferred from direct assay Ref.5. Source: UniProtKB

reverse cholesterol transport

Inferred from sequence or structural similarity. Source: BHF-UCL

small molecule metabolic process

Traceable author statement. Source: Reactome

toxin transport

Inferred from direct assay PubMed 17408620. Source: GOC

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 16780588. Source: UniProtKB

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

endosome

Inferred from sequence or structural similarity. Source: BHF-UCL

external side of plasma membrane

Inferred from direct assay PubMed 16556852. Source: BHF-UCL

integral component of plasma membrane

Inferred by curator Ref.5. Source: UniProtKB

mitochondrion

Inferred from direct assay Ref.14. Source: UniProtKB

plasma membrane

Inferred from direct assay PubMed 16780588. Source: UniProtKB

recycling endosome

Inferred from sequence or structural similarity PubMed 16556852. Source: BHF-UCL

   Molecular_functionADP binding

Inferred from direct assay PubMed 16702602. Source: BHF-UCL

ATP binding

Inferred from direct assay PubMed 16702602. Source: BHF-UCL

cholesterol binding

Inferred by curator PubMed 15994327. Source: BHF-UCL

cholesterol transporter activity

Inferred from direct assay PubMed 15994327. Source: BHF-UCL

glycoprotein transporter activity

Inferred from direct assay PubMed 17293612. Source: BHF-UCL

phospholipid binding

Inferred by curator PubMed 16702602. Source: BHF-UCL

phospholipid transporter activity

Inferred from direct assay PubMed 16702602. Source: BHF-UCL

protein dimerization activity

Non-traceable author statement Ref.5. Source: UniProtKB

protein heterodimerization activity

Inferred from physical interaction PubMed 16870176. Source: BHF-UCL

protein homodimerization activity

Inferred from direct assay PubMed 16870176. Source: BHF-UCL

sterol-transporting ATPase activity

Inferred from direct assay PubMed 17408620. Source: BHF-UCL

toxin transporter activity

Inferred from direct assay PubMed 17408620. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ABCG4Q9H1722EBI-8584087,EBI-8584118

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P45844-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P45844-2)

Also known as: J;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MRISLPRAPERDGGVSASSLLDTVT
     375-386: Missing.
Isoform 3 (identifier: P45844-3)

Also known as: ABDE;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MLGTQGWTKQRKPCPQ
     375-386: Missing.
Isoform 4 (identifier: P45844-4)

Also known as: G;

The sequence of this isoform differs from the canonical sequence as follows:
     375-386: Missing.
Isoform 5 (identifier: P45844-5)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MIMRLPQPHGT
     375-386: Missing.
Isoform 6 (identifier: P45844-6)

Also known as: HI;

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     375-386: Missing.
Isoform 7 (identifier: P45844-7)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     375-386: Missing.
Isoform 8 (identifier: P45844-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MACLMAAFSV...VPEGPWWRKK → MVRRGWSVCT...WGFPGDPMEE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 678678ATP-binding cassette sub-family G member 1
PRO_0000093384

Regions

Topological domain1 – 426426Cytoplasmic Potential
Transmembrane427 – 44519Helical; Potential
Topological domain446 – 45611Extracellular Potential
Transmembrane457 – 47721Helical; Potential
Topological domain478 – 50629Cytoplasmic Potential
Transmembrane507 – 52519Helical; Potential
Topological domain526 – 5338Extracellular Potential
Transmembrane534 – 55522Helical; Potential
Topological domain556 – 56712Cytoplasmic Potential
Transmembrane568 – 58619Helical; Potential
Topological domain587 – 64963Extracellular Potential
Transmembrane650 – 66920Helical; Potential
Topological domain670 – 6789Cytoplasmic Potential
Domain77 – 317241ABC transporter
Domain415 – 673259ABC transmembrane type-2
Nucleotide binding118 – 1258ATP Potential

Amino acid modifications

Lipidation301S-palmitoyl cysteine Ref.15
Lipidation1541S-palmitoyl cysteine Ref.15
Lipidation3151S-palmitoyl cysteine Ref.15
Lipidation3941S-palmitoyl cysteine Ref.15
Lipidation4061S-palmitoyl cysteine Ref.15

Natural variations

Alternative sequence1 – 9595MACLM…WWRKK → MVRRGWSVCTAILLARLWCL VPTHTFLSEYPEAAEYPHPG WVYWLQMAVAPGHLRAWVMR NNVTTNIPSAFSGTLTHEEK AVLTVFTGTATAVHVQVAAL ASAKLESSVFVTDCVSCKIE NVCDSALQGKRVPMSGLQGS SIVIMPPSNRPLASAASCTW SVQVQGGPHHLGVVAISGKV LSAAHGAGRAYGWGFPGDPM EE in isoform 8.
VSP_010718
Alternative sequence1 – 2222Missing in isoform 7.
VSP_000050
Alternative sequence1 – 1414MACLM…VGTAM → MRISLPRAPERDGGVSASSL LDTVT in isoform 2.
VSP_000047
Alternative sequence1 – 1414MACLM…VGTAM → MLGTQGWTKQRKPCPQ in isoform 3.
VSP_000048
Alternative sequence1 – 1414MACLM…VGTAM → MIMRLPQPHGT in isoform 5.
VSP_000049
Alternative sequence1 – 44Missing in isoform 6.
VSP_000046
Alternative sequence375 – 38612Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7.
VSP_000051
Natural variant6681F → L. Ref.5
VAR_012279

Experimental info

Mutagenesis301C → A: No significant effect. Ref.15
Mutagenesis1541C → A: No significant effect. Ref.15
Mutagenesis3151C → A or S: Significantly decreases ABCG1-mediated cholesterol efflux. Ref.15
Mutagenesis3941C → A: No significant effect. Ref.15
Mutagenesis4061C → A: No significant effect. Ref.15
Sequence conflict381S → T in AAK28839. Ref.4
Sequence conflict381S → T in AAK28841. Ref.4
Sequence conflict4481A → T in CAA62631. Ref.1
Sequence conflict4481A → T in AAK28838. Ref.4
Sequence conflict4481A → T in AAK28839. Ref.4
Sequence conflict4481A → T in AAK28840. Ref.4
Sequence conflict4481A → T in AAK28841. Ref.4
Sequence conflict4481A → T in AAK28842. Ref.4
Sequence conflict4481A → T in AAL06598. Ref.5
Sequence conflict5331R → A in AAC51098. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 5, 2001. Version 3.
Checksum: B901CABDA6C19E09

FASTA67875,592
        10         20         30         40         50         60 
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL 

        70         80         90        100        110        120 
TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS 

       130        140        150        160        170        180 
GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV 

       190        200        210        220        230        240 
SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF 

       250        260        270        280        290        300 
DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 

       310        320        330        340        350        360 
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD 

       370        380        390        400        410        420 
AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS 

       430        440        450        460        470        480 
VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE 

       490        500        510        520        530        540 
MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL 

       550        560        570        580        590        600 
GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS 

       610        620        630        640        650        660 
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI 

       670 
SLRLIAYFVL RYKIRAER 

« Hide

Isoform 2 (J) [UniParc].

Checksum: A08150CF2AF519E3
Show »

FASTA67775,380
Isoform 3 (ABDE) [UniParc].

Checksum: A4184D543C1BC91E
Show »

FASTA66874,611
Isoform 4 (G) [UniParc].

Checksum: 0BBC80F8A08CA01B
Show »

FASTA66674,155
Isoform 5 (F) [UniParc].

Checksum: E9B3EB2B69D9AB20
Show »

FASTA66374,032
Isoform 6 (HI) [UniParc].

Checksum: A40C0D83D0D42B35
Show »

FASTA66273,737
Isoform 7 (C) [UniParc].

Checksum: 5124B0E187F391B8
Show »

FASTA64471,960
Isoform 8 [UniParc].

Checksum: 3E17CE17CA58C7EF
Show »

FASTA78586,628

References

« Hide 'large scale' references
[1]"Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3."
Chen H.M., Rossier C., Lalioti M.D., Lynn A., Chakravarti A., Perrin G., Antonarakis S.E.
Am. J. Hum. Genet. 59:66-75(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-678 (ISOFORMS 1 AND 4).
Tissue: Retina.
[2]"Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region."
Berry A., Scott H.S., Kudoh J., Talior I., Korostishevsky M., Wattenhofer M., Guipponi M., Barras C., Rossier C., Shibuya K., Wang J., Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E., Bonne-Tamir B.
Genomics 68:22-29(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]"The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."
Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
J. Biol. Chem. 276:12427-12433(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), REPRESSION BY ZNF202.
[4]"Genomic sequence and structure of the human ABCG1 (ABC8) gene."
Lorkowski S., Rust S., Engel T., Jung E., Tegelkamp K., Galinski E.A., Assmann G., Cullen P.
Biochem. Biophys. Res. Commun. 280:121-131(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 5; 6 AND 7).
[5]"Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein."
Kennedy M.A., Venkateswaran A., Tarr P.T., Xenarios I., Kudoh J., Shimizu N., Edwards P.A.
J. Biol. Chem. 276:39438-39447(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), VARIANT LEU-668.
[6]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[8]"Isolation and characterization of a mammalian homolog of the Drosophila white gene."
Croop J.M., Tiller G.E., Fletcher J.A., Lux M.L., Raab E., Goldenson D., Son D., Arciniegas S., Wu R.
Gene 185:77-85(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-678.
Tissue: Fetal brain.
[9]"Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols."
Venkateswaran A., Repa J.J., Lobaccaro J.-M.A., Bronson A., Mangelsdorf D.J., Edwards P.A.
J. Biol. Chem. 275:14700-14707(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, PROBABLE FUNCTION.
[10]"ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport."
Klucken J., Buechler C., Orso E., Kaminski W.E., Porsch-Oezcueruemez M., Liebisch G., Kapinsky M., Diederich W., Drobnik W., Dean M., Allikmets R., Schmitz G.
Proc. Natl. Acad. Sci. U.S.A. 97:817-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, PROBABLE FUNCTION.
[11]"Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway."
Kaplan R., Gan X., Menke J.G., Wright S.D., Cai T.-Q.
J. Lipid Res. 43:952-959(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[12]"Role of ABCG1 and other ABCG family members in lipid metabolism."
Schmitz G., Langmann T., Heimerl S.
J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[13]"Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease."
Lorkowski S., Kratz M., Wenner C., Schmidt R., Weitkamp B., Fobker M., Reinhardt J., Rauterberg J., Galinski E.A., Cullen P.
Biochem. Biophys. Res. Commun. 283:821-830(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[14]"Antibody-based protein profiling of the human chromosome 21."
Uhlen M., Oksvold P., Algenas C., Hamsten C., Fagerberg L., Klevebring D., Lundberg E., Odeberg J., Ponten F., Kondo T., Sivertsson A.
Mol. Cell. Proteomics 11:0-0(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.
[15]"Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function."
Gu H.M., Li G., Gao X., Berthiaume L.G., Zhang D.W.
Biochim. Biophys. Acta 1831:1067-1078(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION AT CYS-30; CYS-154; CYS-315; CYS-394 AND CYS-406, MUTAGENESIS OF CYS-30; CYS-154; CYS-315; CYS-394 AND CYS-406.
+Additional computationally mapped references.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91249 mRNA. Translation: CAA62631.1. Different initiation.
AB038161 Genomic DNA. Translation: BAB13728.2. Different initiation.
AJ289137 expand/collapse EMBL AC list , AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA. Translation: CAC00730.1. Different initiation.
AF323658 expand/collapse EMBL AC list , AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28836.1.
AF323664 mRNA. Translation: AAK28842.1.
AF323658 expand/collapse EMBL AC list , AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28833.1.
AF323660 mRNA. Translation: AAK28838.1.
AF323663 mRNA. Translation: AAK28841.1. Different initiation.
AF323658 expand/collapse EMBL AC list , AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28835.1.
AF323662 mRNA. Translation: AAK28840.1.
AF323658 expand/collapse EMBL AC list , AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28837.1.
AF323658 expand/collapse EMBL AC list , AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28834.1.
AF323661 mRNA. Translation: AAK28839.1.
AY048757 mRNA. Translation: AAL06598.1.
AP001746 Genomic DNA. Translation: BAA95530.1. Different initiation.
BC029158 mRNA. Translation: AAH29158.2.
U34919 mRNA. Translation: AAC51098.1. Different initiation.
RefSeqNP_004906.3. NM_004915.3.
NP_058198.2. NM_016818.2.
NP_997057.1. NM_207174.1.
NP_997510.1. NM_207627.1.
NP_997511.1. NM_207628.1.
NP_997512.1. NM_207629.1.
UniGeneHs.124649.
Hs.418279.

3D structure databases

ProteinModelPortalP45844.
SMRP45844. Positions 9-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114980. 2 interactions.
IntActP45844. 2 interactions.

Chemistry

DrugBankDB00171. Adenosine triphosphate.

Protein family/group databases

TCDB3.A.1.204.12. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSiteP45844.

Polymorphism databases

DMDM17433715.

Proteomic databases

PaxDbP45844.
PRIDEP45844.

Protocols and materials databases

DNASU9619.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343687; ENSP00000339744; ENSG00000160179. [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179. [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179. [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179. [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179. [P45844-3]
GeneID9619.
KEGGhsa:9619.
UCSCuc002zam.3. human. [P45844-7]
uc002zan.3. human. [P45844-3]
uc002zao.3. human. [P45844-5]
uc002zap.3. human. [P45844-4]
uc002zaq.3. human. [P45844-1]
uc002zar.3. human. [P45844-2]

Organism-specific databases

CTD9619.
GeneCardsGC21P043619.
HGNCHGNC:73. ABCG1.
HPAHPA031470.
HPA031471.
MIM603076. gene.
neXtProtNX_P45844.
PharmGKBPA24408.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1131.
HOVERGENHBG103052.
KOK05679.
OMASYSAAMT.
OrthoDBEOG7KWSGT.
PhylomeDBP45844.
TreeFamTF105210.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP45844.
BgeeP45844.
GenevestigatorP45844.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PfamPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00955. 3a01204. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABCG1. human.
GeneWikiABCG1.
GenomeRNAi9619.
NextBio36087.
PROP45844.
SOURCESearch...

Entry information

Entry nameABCG1_HUMAN
AccessionPrimary (citable) accession number: P45844
Secondary accession number(s): Q86SU8 expand/collapse secondary AC list , Q96L76, Q9BXK6, Q9BXK7, Q9BXK8, Q9BXK9, Q9BXL0, Q9BXL1, Q9BXL2, Q9BXL3, Q9BXL4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 5, 2001
Last modified: April 16, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM