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P45844

- ABCG1_HUMAN

UniProt

P45844 - ABCG1_HUMAN

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Protein

ATP-binding cassette sub-family G member 1

Gene
ABCG1, ABC8, WHT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1258ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: BHF-UCL
  2. ATP binding Source: BHF-UCL
  3. cholesterol binding Source: BHF-UCL
  4. cholesterol transporter activity Source: BHF-UCL
  5. glycoprotein transporter activity Source: BHF-UCL
  6. phospholipid binding Source: BHF-UCL
  7. phospholipid transporter activity Source: BHF-UCL
  8. protein binding Source: IntAct
  9. protein dimerization activity Source: UniProtKB
  10. protein heterodimerization activity Source: BHF-UCL
  11. protein homodimerization activity Source: BHF-UCL
  12. sterol-transporting ATPase activity Source: BHF-UCL
  13. toxin transporter activity Source: BHF-UCL

GO - Biological processi

  1. amyloid precursor protein catabolic process Source: BHF-UCL
  2. cholesterol efflux Source: BHF-UCL
  3. cholesterol homeostasis Source: BHF-UCL
  4. cholesterol metabolic process Source: BHF-UCL
  5. detection of hormone stimulus Source: UniProtKB
  6. glycoprotein transport Source: BHF-UCL
  7. high-density lipoprotein particle remodeling Source: BHF-UCL
  8. intracellular cholesterol transport Source: BHF-UCL
  9. lipoprotein metabolic process Source: Reactome
  10. low-density lipoprotein particle remodeling Source: BHF-UCL
  11. negative regulation of cholesterol storage Source: BHF-UCL
  12. negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  13. phospholipid efflux Source: BHF-UCL
  14. phospholipid homeostasis Source: BHF-UCL
  15. positive regulation of cholesterol biosynthetic process Source: BHF-UCL
  16. positive regulation of cholesterol efflux Source: Ensembl
  17. regulation of cholesterol esterification Source: BHF-UCL
  18. regulation of transcription, DNA-templated Source: BHF-UCL
  19. response to high density lipoprotein particle Source: Ensembl
  20. response to lipid Source: BHF-UCL
  21. response to organic substance Source: UniProtKB
  22. reverse cholesterol transport Source: BHF-UCL
  23. small molecule metabolic process Source: Reactome
  24. toxin transport Source: GOC
  25. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_111158. ABCA transporters in lipid homeostasis.
REACT_13621. HDL-mediated lipid transport.

Protein family/group databases

TCDBi3.A.1.204.12. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene namesi
Name:ABCG1
Synonyms:ABC8, WHT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:73. ABCG1.

Subcellular locationi

Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Note: Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 426426Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei427 – 44519Helical; Reviewed predictionAdd
BLAST
Topological domaini446 – 45611Extracellular Reviewed predictionAdd
BLAST
Transmembranei457 – 47721Helical; Reviewed predictionAdd
BLAST
Topological domaini478 – 50629Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei507 – 52519Helical; Reviewed predictionAdd
BLAST
Topological domaini526 – 5338Extracellular Reviewed prediction
Transmembranei534 – 55522Helical; Reviewed predictionAdd
BLAST
Topological domaini556 – 56712Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei568 – 58619Helical; Reviewed predictionAdd
BLAST
Topological domaini587 – 64963Extracellular Reviewed predictionAdd
BLAST
Transmembranei650 – 66920Helical; Reviewed predictionAdd
BLAST
Topological domaini670 – 6789Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. endosome Source: BHF-UCL
  3. external side of plasma membrane Source: BHF-UCL
  4. Golgi apparatus Source: UniProtKB
  5. Golgi membrane Source: UniProtKB-SubCell
  6. integral component of plasma membrane Source: UniProtKB
  7. mitochondrion Source: UniProtKB
  8. plasma membrane Source: UniProtKB
  9. recycling endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi30 – 301C → A: No significant effect. 1 Publication
Mutagenesisi154 – 1541C → A: No significant effect. 1 Publication
Mutagenesisi315 – 3151C → A or S: Significantly decreases ABCG1-mediated cholesterol efflux. 1 Publication
Mutagenesisi394 – 3941C → A: No significant effect. 1 Publication
Mutagenesisi406 – 4061C → A: No significant effect. 1 Publication

Organism-specific databases

PharmGKBiPA24408.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678ATP-binding cassette sub-family G member 1PRO_0000093384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi30 – 301S-palmitoyl cysteine1 Publication
Lipidationi154 – 1541S-palmitoyl cysteine1 Publication
Lipidationi315 – 3151S-palmitoyl cysteine1 Publication
Lipidationi394 – 3941S-palmitoyl cysteine1 Publication
Lipidationi406 – 4061S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP45844.
PaxDbiP45844.
PRIDEiP45844.

PTM databases

PhosphoSiteiP45844.

Expressioni

Tissue specificityi

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.1 Publication

Inductioni

Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.3 Publications

Gene expression databases

ArrayExpressiP45844.
BgeeiP45844.
GenevestigatoriP45844.

Organism-specific databases

HPAiHPA031470.
HPA031471.

Interactioni

Subunit structurei

May form heterodimers with several heterologous partners of the ABCG subfamily.

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCG4Q9H1722EBI-8584087,EBI-8584118

Protein-protein interaction databases

BioGridi114980. 2 interactions.
IntActiP45844. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP45844.
SMRiP45844. Positions 9-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 317241ABC transporterAdd
BLAST
Domaini415 – 673259ABC transmembrane type-2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
HOVERGENiHBG103052.
KOiK05679.
OMAiRERICDT.
OrthoDBiEOG7KWSGT.
PhylomeDBiP45844.
TreeFamiTF105210.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P45844-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN    50
GHLKKVDNNL TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL 100
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGLPR 150
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI 200
LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA 250
SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 300
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD 350
SDHKRDLGGD AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS 400
CLTQFCILFK RTFLSIMRDS VLTHLRITSH IGIGLLIGLL YLGIGNEAKK 450
VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE MGVFLREHLN YWYSLKAYYL 500
AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL GTMTSLVAQS 550
LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS 600
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL 650
DFIVLGIFFI SLRLIAYFVL RYKIRAER 678
Length:678
Mass (Da):75,592
Last modified:December 5, 2001 - v3
Checksum:iB901CABDA6C19E09
GO
Isoform 2 (identifier: P45844-2) [UniParc]FASTAAdd to Basket

Also known as: J

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MRISLPRAPERDGGVSASSLLDTVT
     375-386: Missing.

Show »
Length:677
Mass (Da):75,380
Checksum:iA08150CF2AF519E3
GO
Isoform 3 (identifier: P45844-3) [UniParc]FASTAAdd to Basket

Also known as: ABDE

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MLGTQGWTKQRKPCPQ
     375-386: Missing.

Show »
Length:668
Mass (Da):74,611
Checksum:iA4184D543C1BC91E
GO
Isoform 4 (identifier: P45844-4) [UniParc]FASTAAdd to Basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     375-386: Missing.

Show »
Length:666
Mass (Da):74,155
Checksum:i0BBC80F8A08CA01B
GO
Isoform 5 (identifier: P45844-5) [UniParc]FASTAAdd to Basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MIMRLPQPHGT
     375-386: Missing.

Show »
Length:663
Mass (Da):74,032
Checksum:iE9B3EB2B69D9AB20
GO
Isoform 6 (identifier: P45844-6) [UniParc]FASTAAdd to Basket

Also known as: HI

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     375-386: Missing.

Show »
Length:662
Mass (Da):73,737
Checksum:iA40C0D83D0D42B35
GO
Isoform 7 (identifier: P45844-7) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     375-386: Missing.

Show »
Length:644
Mass (Da):71,960
Checksum:i5124B0E187F391B8
GO
Isoform 8 (identifier: P45844-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MACLMAAFSV...VPEGPWWRKK → MVRRGWSVCT...WGFPGDPMEE

Show »
Length:785
Mass (Da):86,628
Checksum:i3E17CE17CA58C7EF
GO

Sequence cautioni

The sequence AAC51098.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAK28841.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA95530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB13728.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA62631.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAC00730.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti668 – 6681F → L.1 Publication
VAR_012279

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9595MACLM…WWRKK → MVRRGWSVCTAILLARLWCL VPTHTFLSEYPEAAEYPHPG WVYWLQMAVAPGHLRAWVMR NNVTTNIPSAFSGTLTHEEK AVLTVFTGTATAVHVQVAAL ASAKLESSVFVTDCVSCKIE NVCDSALQGKRVPMSGLQGS SIVIMPPSNRPLASAASCTW SVQVQGGPHHLGVVAISGKV LSAAHGAGRAYGWGFPGDPM EE in isoform 8. VSP_010718Add
BLAST
Alternative sequencei1 – 2222Missing in isoform 7. VSP_000050Add
BLAST
Alternative sequencei1 – 1414MACLM…VGTAM → MRISLPRAPERDGGVSASSL LDTVT in isoform 2. VSP_000047Add
BLAST
Alternative sequencei1 – 1414MACLM…VGTAM → MLGTQGWTKQRKPCPQ in isoform 3. VSP_000048Add
BLAST
Alternative sequencei1 – 1414MACLM…VGTAM → MIMRLPQPHGT in isoform 5. VSP_000049Add
BLAST
Alternative sequencei1 – 44Missing in isoform 6. VSP_000046
Alternative sequencei375 – 38612Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. VSP_000051Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381S → T in AAK28839. 1 Publication
Sequence conflicti38 – 381S → T in AAK28841. 1 Publication
Sequence conflicti448 – 4481A → T in CAA62631. 1 Publication
Sequence conflicti448 – 4481A → T in AAK28838. 1 Publication
Sequence conflicti448 – 4481A → T in AAK28839. 1 Publication
Sequence conflicti448 – 4481A → T in AAK28840. 1 Publication
Sequence conflicti448 – 4481A → T in AAK28841. 1 Publication
Sequence conflicti448 – 4481A → T in AAK28842. 1 Publication
Sequence conflicti448 – 4481A → T in AAL06598. 1 Publication
Sequence conflicti533 – 5331R → A in AAC51098. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91249 mRNA. Translation: CAA62631.1. Different initiation.
AB038161 Genomic DNA. Translation: BAB13728.2. Different initiation.
AJ289137
, AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA. Translation: CAC00730.1. Different initiation.
AF323658
, AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28836.1.
AF323664 mRNA. Translation: AAK28842.1.
AF323658
, AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28833.1.
AF323660 mRNA. Translation: AAK28838.1.
AF323663 mRNA. Translation: AAK28841.1. Different initiation.
AF323658
, AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28835.1.
AF323662 mRNA. Translation: AAK28840.1.
AF323658
, AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28837.1.
AF323658
, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28834.1.
AF323661 mRNA. Translation: AAK28839.1.
AY048757 mRNA. Translation: AAL06598.1.
AP001746 Genomic DNA. Translation: BAA95530.1. Different initiation.
BC029158 mRNA. Translation: AAH29158.2.
U34919 mRNA. Translation: AAC51098.1. Different initiation.
CCDSiCCDS13681.1. [P45844-5]
CCDS13682.1. [P45844-1]
CCDS13683.1. [P45844-2]
CCDS42937.1. [P45844-3]
CCDS42938.1. [P45844-4]
RefSeqiNP_004906.3. NM_004915.3. [P45844-1]
NP_058198.2. NM_016818.2. [P45844-4]
NP_997057.1. NM_207174.1. [P45844-2]
NP_997510.1. NM_207627.1. [P45844-3]
NP_997511.1. NM_207628.1. [P45844-7]
NP_997512.1. NM_207629.1. [P45844-5]
UniGeneiHs.124649.
Hs.418279.

Genome annotation databases

EnsembliENST00000343687; ENSP00000339744; ENSG00000160179. [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179. [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179. [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179. [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179. [P45844-3]
GeneIDi9619.
KEGGihsa:9619.
UCSCiuc002zam.3. human. [P45844-7]
uc002zan.3. human. [P45844-3]
uc002zao.3. human. [P45844-5]
uc002zap.3. human. [P45844-4]
uc002zaq.3. human. [P45844-1]
uc002zar.3. human. [P45844-2]

Polymorphism databases

DMDMi17433715.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91249 mRNA. Translation: CAA62631.1 . Different initiation.
AB038161 Genomic DNA. Translation: BAB13728.2 . Different initiation.
AJ289137
, AJ289138 , AJ289139 , AJ289140 , AJ289141 , AJ289142 , AJ289143 , AJ289144 , AJ289145 , AJ289146 , AJ289147 , AJ289148 , AJ289149 , AJ289150 , AJ289151 Genomic DNA. Translation: CAC00730.1 . Different initiation.
AF323658
, AF323644 , AF323645 , AF323646 , AF323647 , AF323648 , AF323649 , AF323650 , AF323651 , AF323652 , AF323653 , AF323654 , AF323655 , AF323656 , AF323657 Genomic DNA. Translation: AAK28836.1 .
AF323664 mRNA. Translation: AAK28842.1 .
AF323658
, AF323640 , AF323645 , AF323646 , AF323647 , AF323648 , AF323649 , AF323650 , AF323651 , AF323652 , AF323653 , AF323654 , AF323655 , AF323656 , AF323657 Genomic DNA. Translation: AAK28833.1 .
AF323660 mRNA. Translation: AAK28838.1 .
AF323663 mRNA. Translation: AAK28841.1 . Different initiation.
AF323658
, AF323642 , AF323645 , AF323646 , AF323647 , AF323648 , AF323649 , AF323650 , AF323651 , AF323652 , AF323653 , AF323654 , AF323655 , AF323656 , AF323657 Genomic DNA. Translation: AAK28835.1 .
AF323662 mRNA. Translation: AAK28840.1 .
AF323658
, AF323643 , AF323645 , AF323646 , AF323647 , AF323648 , AF323649 , AF323650 , AF323651 , AF323652 , AF323653 , AF323654 , AF323655 , AF323656 , AF323657 Genomic DNA. Translation: AAK28837.1 .
AF323658
, AF323645 , AF323646 , AF323647 , AF323648 , AF323649 , AF323650 , AF323651 , AF323652 , AF323653 , AF323654 , AF323655 , AF323656 , AF323657 Genomic DNA. Translation: AAK28834.1 .
AF323661 mRNA. Translation: AAK28839.1 .
AY048757 mRNA. Translation: AAL06598.1 .
AP001746 Genomic DNA. Translation: BAA95530.1 . Different initiation.
BC029158 mRNA. Translation: AAH29158.2 .
U34919 mRNA. Translation: AAC51098.1 . Different initiation.
CCDSi CCDS13681.1. [P45844-5 ]
CCDS13682.1. [P45844-1 ]
CCDS13683.1. [P45844-2 ]
CCDS42937.1. [P45844-3 ]
CCDS42938.1. [P45844-4 ]
RefSeqi NP_004906.3. NM_004915.3. [P45844-1 ]
NP_058198.2. NM_016818.2. [P45844-4 ]
NP_997057.1. NM_207174.1. [P45844-2 ]
NP_997510.1. NM_207627.1. [P45844-3 ]
NP_997511.1. NM_207628.1. [P45844-7 ]
NP_997512.1. NM_207629.1. [P45844-5 ]
UniGenei Hs.124649.
Hs.418279.

3D structure databases

ProteinModelPortali P45844.
SMRi P45844. Positions 9-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114980. 2 interactions.
IntActi P45844. 2 interactions.

Chemistry

DrugBanki DB00171. Adenosine triphosphate.

Protein family/group databases

TCDBi 3.A.1.204.12. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei P45844.

Polymorphism databases

DMDMi 17433715.

Proteomic databases

MaxQBi P45844.
PaxDbi P45844.
PRIDEi P45844.

Protocols and materials databases

DNASUi 9619.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343687 ; ENSP00000339744 ; ENSG00000160179 . [P45844-2 ]
ENST00000347800 ; ENSP00000291524 ; ENSG00000160179 . [P45844-5 ]
ENST00000361802 ; ENSP00000354995 ; ENSG00000160179 . [P45844-1 ]
ENST00000398449 ; ENSP00000381467 ; ENSG00000160179 . [P45844-4 ]
ENST00000398457 ; ENSP00000381475 ; ENSG00000160179 . [P45844-3 ]
GeneIDi 9619.
KEGGi hsa:9619.
UCSCi uc002zam.3. human. [P45844-7 ]
uc002zan.3. human. [P45844-3 ]
uc002zao.3. human. [P45844-5 ]
uc002zap.3. human. [P45844-4 ]
uc002zaq.3. human. [P45844-1 ]
uc002zar.3. human. [P45844-2 ]

Organism-specific databases

CTDi 9619.
GeneCardsi GC21P043619.
HGNCi HGNC:73. ABCG1.
HPAi HPA031470.
HPA031471.
MIMi 603076. gene.
neXtProti NX_P45844.
PharmGKBi PA24408.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1131.
HOVERGENi HBG103052.
KOi K05679.
OMAi RERICDT.
OrthoDBi EOG7KWSGT.
PhylomeDBi P45844.
TreeFami TF105210.

Enzyme and pathway databases

Reactomei REACT_111158. ABCA transporters in lipid homeostasis.
REACT_13621. HDL-mediated lipid transport.

Miscellaneous databases

ChiTaRSi ABCG1. human.
GeneWikii ABCG1.
GenomeRNAii 9619.
NextBioi 36087.
PROi P45844.
SOURCEi Search...

Gene expression databases

ArrayExpressi P45844.
Bgeei P45844.
Genevestigatori P45844.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view ]
PANTHERi PTHR19241:SF177. PTHR19241:SF177. 1 hit.
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00955. 3a01204. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3."
    Chen H.M., Rossier C., Lalioti M.D., Lynn A., Chakravarti A., Perrin G., Antonarakis S.E.
    Am. J. Hum. Genet. 59:66-75(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-678 (ISOFORMS 1 AND 4).
    Tissue: Retina.
  2. "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region."
    Berry A., Scott H.S., Kudoh J., Talior I., Korostishevsky M., Wattenhofer M., Guipponi M., Barras C., Rossier C., Shibuya K., Wang J., Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E., Bonne-Tamir B.
    Genomics 68:22-29(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux."
    Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
    J. Biol. Chem. 276:12427-12433(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), REPRESSION BY ZNF202.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 5; 6 AND 7).
  5. "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein."
    Kennedy M.A., Venkateswaran A., Tarr P.T., Xenarios I., Kudoh J., Shimizu N., Edwards P.A.
    J. Biol. Chem. 276:39438-39447(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8), VARIANT LEU-668.
  6. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  8. "Isolation and characterization of a mammalian homolog of the Drosophila white gene."
    Croop J.M., Tiller G.E., Fletcher J.A., Lux M.L., Raab E., Goldenson D., Son D., Arciniegas S., Wu R.
    Gene 185:77-85(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-678.
    Tissue: Fetal brain.
  9. "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols."
    Venkateswaran A., Repa J.J., Lobaccaro J.-M.A., Bronson A., Mangelsdorf D.J., Edwards P.A.
    J. Biol. Chem. 275:14700-14707(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, PROBABLE FUNCTION.
  10. "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport."
    Klucken J., Buechler C., Orso E., Kaminski W.E., Porsch-Oezcueruemez M., Liebisch G., Kapinsky M., Diederich W., Drobnik W., Dean M., Allikmets R., Schmitz G.
    Proc. Natl. Acad. Sci. U.S.A. 97:817-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, PROBABLE FUNCTION.
  11. "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway."
    Kaplan R., Gan X., Menke J.G., Wright S.D., Cai T.-Q.
    J. Lipid Res. 43:952-959(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. "Role of ABCG1 and other ABCG family members in lipid metabolism."
    Schmitz G., Langmann T., Heimerl S.
    J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. Cited for: TISSUE SPECIFICITY.
  14. Cited for: SUBCELLULAR LOCATION, MISCELLANEOUS.
  15. "Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function."
    Gu H.M., Li G., Gao X., Berthiaume L.G., Zhang D.W.
    Biochim. Biophys. Acta 1831:1067-1078(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-30; CYS-154; CYS-315; CYS-394 AND CYS-406, MUTAGENESIS OF CYS-30; CYS-154; CYS-315; CYS-394 AND CYS-406.

Entry informationi

Entry nameiABCG1_HUMAN
AccessioniPrimary (citable) accession number: P45844
Secondary accession number(s): Q86SU8
, Q96L76, Q9BXK6, Q9BXK7, Q9BXK8, Q9BXK9, Q9BXL0, Q9BXL1, Q9BXL2, Q9BXL3, Q9BXL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 5, 2001
Last modified: September 3, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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