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Protein

ATP-binding cassette sub-family G member 1

Gene

ABCG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ADP binding Source: BHF-UCL
  • ATP binding Source: BHF-UCL
  • cholesterol binding Source: BHF-UCL
  • cholesterol transporter activity Source: BHF-UCL
  • glycoprotein transporter activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL
  • phospholipid transporter activity Source: BHF-UCL
  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • sterol-transporting ATPase activity Source: BHF-UCL
  • toxin transporter activity Source: BHF-UCL

GO - Biological processi

  • amyloid precursor protein catabolic process Source: BHF-UCL
  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol metabolic process Source: BHF-UCL
  • detection of hormone stimulus Source: UniProtKB
  • glycoprotein transport Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • intracellular cholesterol transport Source: BHF-UCL
  • lipoprotein metabolic process Source: Reactome
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • negative regulation of cholesterol storage Source: BHF-UCL
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • phospholipid efflux Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • positive regulation of cholesterol biosynthetic process Source: BHF-UCL
  • positive regulation of cholesterol efflux Source: Ensembl
  • regulation of cholesterol esterification Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: BHF-UCL
  • response to high density lipoprotein particle Source: Ensembl
  • response to lipid Source: BHF-UCL
  • response to organic substance Source: UniProtKB
  • reverse cholesterol transport Source: BHF-UCL
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160179-MONOMER.
ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.
R-HSA-194223. HDL-mediated lipid transport.

Protein family/group databases

TCDBi3.A.1.204.12. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000420.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
Gene namesi
Name:ABCG1
Synonyms:ABC8, WHT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:73. ABCG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 426CytoplasmicSequence analysisAdd BLAST426
Transmembranei427 – 445HelicalSequence analysisAdd BLAST19
Topological domaini446 – 456ExtracellularSequence analysisAdd BLAST11
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 506CytoplasmicSequence analysisAdd BLAST29
Transmembranei507 – 525HelicalSequence analysisAdd BLAST19
Topological domaini526 – 533ExtracellularSequence analysis8
Transmembranei534 – 555HelicalSequence analysisAdd BLAST22
Topological domaini556 – 567CytoplasmicSequence analysisAdd BLAST12
Transmembranei568 – 586HelicalSequence analysisAdd BLAST19
Topological domaini587 – 649ExtracellularSequence analysisAdd BLAST63
Transmembranei650 – 669HelicalSequence analysisAdd BLAST20
Topological domaini670 – 678CytoplasmicSequence analysis9

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome Source: BHF-UCL
  • external side of plasma membrane Source: BHF-UCL
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: GO_Central
  • integral component of plasma membrane Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • mitochondrion Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → A: No significant effect. 1 Publication1
Mutagenesisi154C → A: No significant effect. 1 Publication1
Mutagenesisi315C → A or S: Significantly decreases ABCG1-mediated cholesterol efflux. 1 Publication1
Mutagenesisi394C → A: No significant effect. 1 Publication1
Mutagenesisi406C → A: No significant effect. 1 Publication1

Organism-specific databases

DisGeNETi9619.
OpenTargetsiENSG00000160179.
PharmGKBiPA24408.

Chemistry databases

DrugBankiDB00171. Adenosine triphosphate.

Polymorphism and mutation databases

BioMutaiABCG1.
DMDMi17433715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933841 – 678ATP-binding cassette sub-family G member 1Add BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi30S-palmitoyl cysteine1 Publication1
Lipidationi154S-palmitoyl cysteine1 Publication1
Lipidationi315S-palmitoyl cysteine1 Publication1
Lipidationi394S-palmitoyl cysteine1 Publication1
Lipidationi406S-palmitoyl cysteine1 Publication1

Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP45844.
PaxDbiP45844.
PeptideAtlasiP45844.
PRIDEiP45844.
TopDownProteomicsiP45844-8. [P45844-8]

PTM databases

iPTMnetiP45844.
PhosphoSitePlusiP45844.
SwissPalmiP45844.

Expressioni

Tissue specificityi

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.1 Publication

Inductioni

Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.4 Publications

Gene expression databases

BgeeiENSG00000160179.
ExpressionAtlasiP45844. baseline and differential.
GenevisibleiP45844. HS.

Organism-specific databases

HPAiHPA031470.
HPA031471.

Interactioni

Subunit structurei

May form heterodimers with several heterologous partners of the ABCG subfamily.

Binary interactionsi

WithEntry#Exp.IntActNotes
ABCG4Q9H1722EBI-8584087,EBI-8584118

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi114980. 59 interactors.
IntActiP45844. 5 interactors.
STRINGi9606.ENSP00000354995.

Structurei

3D structure databases

ProteinModelPortaliP45844.
SMRiP45844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 317ABC transporterPROSITE-ProRule annotationAdd BLAST241
Domaini415 – 673ABC transmembrane type-2Add BLAST259

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG103052.
InParanoidiP45844.
KOiK05679.
OMAiASMEGCH.
PhylomeDBiP45844.
TreeFamiTF105210.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P45844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN
60 70 80 90 100
GHLKKVDNNL TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL
110 120 130 140 150
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGLPR
160 170 180 190 200
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI
210 220 230 240 250
LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA
260 270 280 290 300
SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK
310 320 330 340 350
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD
360 370 380 390 400
SDHKRDLGGD AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS
410 420 430 440 450
CLTQFCILFK RTFLSIMRDS VLTHLRITSH IGIGLLIGLL YLGIGNEAKK
460 470 480 490 500
VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE MGVFLREHLN YWYSLKAYYL
510 520 530 540 550
AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL GTMTSLVAQS
560 570 580 590 600
LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS
610 620 630 640 650
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL
660 670
DFIVLGIFFI SLRLIAYFVL RYKIRAER
Length:678
Mass (Da):75,592
Last modified:December 5, 2001 - v3
Checksum:iB901CABDA6C19E09
GO
Isoform 2 (identifier: P45844-2) [UniParc]FASTAAdd to basket
Also known as: J

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MRISLPRAPERDGGVSASSLLDTVT
     375-386: Missing.

Show »
Length:677
Mass (Da):75,380
Checksum:iA08150CF2AF519E3
GO
Isoform 3 (identifier: P45844-3) [UniParc]FASTAAdd to basket
Also known as: ABDE

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MLGTQGWTKQRKPCPQ
     375-386: Missing.

Show »
Length:668
Mass (Da):74,611
Checksum:iA4184D543C1BC91E
GO
Isoform 4 (identifier: P45844-4) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     375-386: Missing.

Show »
Length:666
Mass (Da):74,155
Checksum:i0BBC80F8A08CA01B
GO
Isoform 5 (identifier: P45844-5) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MIMRLPQPHGT
     375-386: Missing.

Show »
Length:663
Mass (Da):74,032
Checksum:iE9B3EB2B69D9AB20
GO
Isoform 6 (identifier: P45844-6) [UniParc]FASTAAdd to basket
Also known as: HI

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     375-386: Missing.

Show »
Length:662
Mass (Da):73,737
Checksum:iA40C0D83D0D42B35
GO
Isoform 7 (identifier: P45844-7) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     375-386: Missing.

Show »
Length:644
Mass (Da):71,960
Checksum:i5124B0E187F391B8
GO
Isoform 8 (identifier: P45844-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MACLMAAFSV...VPEGPWWRKK → MVRRGWSVCT...WGFPGDPMEE

Show »
Length:785
Mass (Da):86,628
Checksum:i3E17CE17CA58C7EF
GO

Sequence cautioni

The sequence AAC51098 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK28841 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA95530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC00730 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → T in AAK28839 (PubMed:11162488).Curated1
Sequence conflicti38S → T in AAK28841 (PubMed:11162488).Curated1
Sequence conflicti448A → T in CAA62631 (PubMed:8659545).Curated1
Sequence conflicti448A → T in AAK28838 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28839 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28840 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28841 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28842 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAL06598 (PubMed:11500512).Curated1
Sequence conflicti533R → A in AAC51098 (PubMed:9034316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012279668F → L.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0107181 – 95MACLM…WWRKK → MVRRGWSVCTAILLARLWCL VPTHTFLSEYPEAAEYPHPG WVYWLQMAVAPGHLRAWVMR NNVTTNIPSAFSGTLTHEEK AVLTVFTGTATAVHVQVAAL ASAKLESSVFVTDCVSCKIE NVCDSALQGKRVPMSGLQGS SIVIMPPSNRPLASAASCTW SVQVQGGPHHLGVVAISGKV LSAAHGAGRAYGWGFPGDPM EE in isoform 8. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0000501 – 22Missing in isoform 7. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0000471 – 14MACLM…VGTAM → MRISLPRAPERDGGVSASSL LDTVT in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000481 – 14MACLM…VGTAM → MLGTQGWTKQRKPCPQ in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000491 – 14MACLM…VGTAM → MIMRLPQPHGT in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000461 – 4Missing in isoform 6. 1 Publication4
Alternative sequenceiVSP_000051375 – 386Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91249 mRNA. Translation: CAA62631.1. Different initiation.
AB038161 Genomic DNA. Translation: BAB13728.2. Different initiation.
AJ289137
, AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA. Translation: CAC00730.1. Different initiation.
AF323658
, AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28836.1.
AF323664 mRNA. Translation: AAK28842.1.
AF323658
, AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28833.1.
AF323660 mRNA. Translation: AAK28838.1.
AF323663 mRNA. Translation: AAK28841.1. Different initiation.
AF323658
, AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28835.1.
AF323662 mRNA. Translation: AAK28840.1.
AF323658
, AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28837.1.
AF323658
, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28834.1.
AF323661 mRNA. Translation: AAK28839.1.
AY048757 mRNA. Translation: AAL06598.1.
AP001746 Genomic DNA. Translation: BAA95530.1. Different initiation.
BC029158 mRNA. Translation: AAH29158.2.
U34919 mRNA. Translation: AAC51098.1. Different initiation.
CCDSiCCDS13681.1. [P45844-5]
CCDS13682.1. [P45844-1]
CCDS13683.1. [P45844-2]
CCDS42937.1. [P45844-3]
CCDS42938.1. [P45844-4]
RefSeqiNP_004906.3. NM_004915.3. [P45844-1]
NP_058198.2. NM_016818.2. [P45844-4]
NP_997057.1. NM_207174.1. [P45844-2]
NP_997510.1. NM_207627.1. [P45844-3]
NP_997511.1. NM_207628.1. [P45844-7]
NP_997512.1. NM_207629.1. [P45844-5]
UniGeneiHs.124649.
Hs.418279.

Genome annotation databases

EnsembliENST00000343687; ENSP00000339744; ENSG00000160179. [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179. [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179. [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179. [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179. [P45844-3]
GeneIDi9619.
KEGGihsa:9619.
UCSCiuc002zan.3. human. [P45844-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91249 mRNA. Translation: CAA62631.1. Different initiation.
AB038161 Genomic DNA. Translation: BAB13728.2. Different initiation.
AJ289137
, AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA. Translation: CAC00730.1. Different initiation.
AF323658
, AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28836.1.
AF323664 mRNA. Translation: AAK28842.1.
AF323658
, AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28833.1.
AF323660 mRNA. Translation: AAK28838.1.
AF323663 mRNA. Translation: AAK28841.1. Different initiation.
AF323658
, AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28835.1.
AF323662 mRNA. Translation: AAK28840.1.
AF323658
, AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28837.1.
AF323658
, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA. Translation: AAK28834.1.
AF323661 mRNA. Translation: AAK28839.1.
AY048757 mRNA. Translation: AAL06598.1.
AP001746 Genomic DNA. Translation: BAA95530.1. Different initiation.
BC029158 mRNA. Translation: AAH29158.2.
U34919 mRNA. Translation: AAC51098.1. Different initiation.
CCDSiCCDS13681.1. [P45844-5]
CCDS13682.1. [P45844-1]
CCDS13683.1. [P45844-2]
CCDS42937.1. [P45844-3]
CCDS42938.1. [P45844-4]
RefSeqiNP_004906.3. NM_004915.3. [P45844-1]
NP_058198.2. NM_016818.2. [P45844-4]
NP_997057.1. NM_207174.1. [P45844-2]
NP_997510.1. NM_207627.1. [P45844-3]
NP_997511.1. NM_207628.1. [P45844-7]
NP_997512.1. NM_207629.1. [P45844-5]
UniGeneiHs.124649.
Hs.418279.

3D structure databases

ProteinModelPortaliP45844.
SMRiP45844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114980. 59 interactors.
IntActiP45844. 5 interactors.
STRINGi9606.ENSP00000354995.

Chemistry databases

DrugBankiDB00171. Adenosine triphosphate.
SwissLipidsiSLP:000000420.

Protein family/group databases

TCDBi3.A.1.204.12. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP45844.
PhosphoSitePlusiP45844.
SwissPalmiP45844.

Polymorphism and mutation databases

BioMutaiABCG1.
DMDMi17433715.

Proteomic databases

MaxQBiP45844.
PaxDbiP45844.
PeptideAtlasiP45844.
PRIDEiP45844.
TopDownProteomicsiP45844-8. [P45844-8]

Protocols and materials databases

DNASUi9619.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343687; ENSP00000339744; ENSG00000160179. [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179. [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179. [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179. [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179. [P45844-3]
GeneIDi9619.
KEGGihsa:9619.
UCSCiuc002zan.3. human. [P45844-1]

Organism-specific databases

CTDi9619.
DisGeNETi9619.
GeneCardsiABCG1.
HGNCiHGNC:73. ABCG1.
HPAiHPA031470.
HPA031471.
MIMi603076. gene.
neXtProtiNX_P45844.
OpenTargetsiENSG00000160179.
PharmGKBiPA24408.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG103052.
InParanoidiP45844.
KOiK05679.
OMAiASMEGCH.
PhylomeDBiP45844.
TreeFamiTF105210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160179-MONOMER.
ReactomeiR-HSA-1369062. ABC transporters in lipid homeostasis.
R-HSA-194223. HDL-mediated lipid transport.

Miscellaneous databases

ChiTaRSiABCG1. human.
GeneWikiiABCG1.
GenomeRNAii9619.
PROiP45844.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160179.
ExpressionAtlasiP45844. baseline and differential.
GenevisibleiP45844. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR020064. ABCG1.
IPR027417. P-loop_NTPase.
IPR005284. Pigment_permease.
[Graphical view]
PANTHERiPTHR19241:SF177. PTHR19241:SF177. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00955. 3a01204. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCG1_HUMAN
AccessioniPrimary (citable) accession number: P45844
Secondary accession number(s): Q86SU8
, Q96L76, Q9BXK6, Q9BXK7, Q9BXK8, Q9BXK9, Q9BXL0, Q9BXL1, Q9BXL2, Q9BXL3, Q9BXL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 5, 2001
Last modified: November 2, 2016
This is version 175 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.