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P45840

- SYR_MYCLE

UniProt

P45840 - SYR_MYCLE

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:ML1127
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1127.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Arginine--tRNA ligasePRO_0000151577Add
    BLAST

    Proteomic databases

    PRIDEiP45840.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML1127.

    Structurei

    3D structure databases

    ProteinModelPortaliP45840.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi130 – 14011"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247214.
    KOiK01887.
    OMAiMEHMGFG.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P45840-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPADLAELL KTTAIVVLAE RGLDAAALPQ TVTVERPRNP EHGDYSSNLA    50
    MQLGKKVGAN PLELAGWLAE VLAQAGGIAD VEVAGPGFIN MRLDASAQAM 100
    IVNTVINADK NFGHSDDLAG YQINLEFVSA NPTGPIHIGG TRWAAVGDAL 150
    GRLLSTQGAA VVREYYFNDH GAQIDRFTNS LIAAAKGELT PADGYAGTYV 200
    TDIAAQVMQQ APYALSLPES EMHETVREIG VDLMFTHIKK SLHEFGTDFD 250
    VYTHEDSMHA SGRVDEAIAR LRDTGNVYEK DGALWLRTSA FGDDKDRVVI 300
    KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG 350
    DDPAIVEVLI GQMVNLVCDG QLVRMSKRSG NVITLDDLVE AIGVDAARYS 400
    LIRSSVDTPI DIDLALWSSS SNENPVYYVQ YAHARLSALA RNAAEFGLIP 450
    DTGHLELLSH DKEGALLRTV GEFPQVLKTA AALREPHRVC RYLEDLAGDY 500
    HRFYDSCRVL PQGDEKPTDL HTARLALCQA NRQVIANGLA ILGVSAPERM 550
    Length:550
    Mass (Da):59,603
    Last modified:April 27, 2001 - v3
    Checksum:iDBD8A95A9B9831BB
    GO

    Sequence cautioni

    The sequence AAA63099.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741I → V in AAA63099. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15186 Genomic DNA. Translation: AAA63099.1. Different initiation.
    AL583920 Genomic DNA. Translation: CAC31508.1.
    PIRiA87050.
    RefSeqiNP_301821.1. NC_002677.1.
    WP_010908145.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC31508; CAC31508; CAC31508.
    GeneIDi910221.
    KEGGimle:ML1127.
    PATRICi18054209. VBIMycLep78757_2049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15186 Genomic DNA. Translation: AAA63099.1 . Different initiation.
    AL583920 Genomic DNA. Translation: CAC31508.1 .
    PIRi A87050.
    RefSeqi NP_301821.1. NC_002677.1.
    WP_010908145.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P45840.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1127.

    Proteomic databases

    PRIDEi P45840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC31508 ; CAC31508 ; CAC31508 .
    GeneIDi 910221.
    KEGGi mle:ML1127.
    PATRICi 18054209. VBIMycLep78757_2049.

    Organism-specific databases

    Lepromai ML1127.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247214.
    KOi K01887.
    OMAi MEHMGFG.
    OrthoDBi EOG6JB13C.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Smith D.R., Robison K.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiSYR_MYCLE
    AccessioniPrimary (citable) accession number: P45840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3