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P45840 (SYR_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:ML1127
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAA63099.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151577

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Experimental info

Sequence conflict1741I → V in AAA63099. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P45840 [UniParc].

Last modified April 27, 2001. Version 3.
Checksum: DBD8A95A9B9831BB

FASTA55059,603
        10         20         30         40         50         60 
MTPADLAELL KTTAIVVLAE RGLDAAALPQ TVTVERPRNP EHGDYSSNLA MQLGKKVGAN 

        70         80         90        100        110        120 
PLELAGWLAE VLAQAGGIAD VEVAGPGFIN MRLDASAQAM IVNTVINADK NFGHSDDLAG 

       130        140        150        160        170        180 
YQINLEFVSA NPTGPIHIGG TRWAAVGDAL GRLLSTQGAA VVREYYFNDH GAQIDRFTNS 

       190        200        210        220        230        240 
LIAAAKGELT PADGYAGTYV TDIAAQVMQQ APYALSLPES EMHETVREIG VDLMFTHIKK 

       250        260        270        280        290        300 
SLHEFGTDFD VYTHEDSMHA SGRVDEAIAR LRDTGNVYEK DGALWLRTSA FGDDKDRVVI 

       310        320        330        340        350        360 
KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG DDPAIVEVLI 

       370        380        390        400        410        420 
GQMVNLVCDG QLVRMSKRSG NVITLDDLVE AIGVDAARYS LIRSSVDTPI DIDLALWSSS 

       430        440        450        460        470        480 
SNENPVYYVQ YAHARLSALA RNAAEFGLIP DTGHLELLSH DKEGALLRTV GEFPQVLKTA 

       490        500        510        520        530        540 
AALREPHRVC RYLEDLAGDY HRFYDSCRVL PQGDEKPTDL HTARLALCQA NRQVIANGLA 

       550 
ILGVSAPERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15186 Genomic DNA. Translation: AAA63099.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31508.1.
PIRA87050.
RefSeqNP_301821.1. NC_002677.1.

3D structure databases

ProteinModelPortalP45840.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML1127.

Proteomic databases

PRIDEP45840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC31508; CAC31508; CAC31508.
GeneID910221.
KEGGmle:ML1127.
PATRIC18054209. VBIMycLep78757_2049.

Organism-specific databases

LepromaML1127.
CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCLE
AccessionPrimary (citable) accession number: P45840
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries