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P45837

- THRC_MYCLE

UniProt

P45837 - THRC_MYCLE

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Protein
Threonine synthase
Gene
thrC, ML1130
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Pyridoxal phosphate By similarity
Binding sitei326 – 3261Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:ML1130
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Threonine synthase
PRO_0000185636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi272631.ML1130.

Structurei

3D structure databases

ProteinModelPortaliP45837.
SMRiP45837. Positions 10-358.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 2005Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
KOiK01733.
OMAiDPDWAVA.
OrthoDBiEOG6HMX9M.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45837-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQQTTTHQ PWPGVIAAYR DRLPVGDDWT PVTLLEGGTP LIAAPRLSEQ    50
TGCTIHLKVE GLNPTGSFKD RGMTMAVTDA LARGQRAVLC ASTGNTSASA 100
AAYAARAGIT CAVLIPQGKI AMGKLAQAVM HGAKIIQIDG NFDDCLELAR 150
KMAADFPMIS LVNSVNPVRI EGQKTAVFEI VDALGTAPHV HALPVGNAGN 200
ITAYWKGYTE YHADGLIDRL PRMLGTQAAG AAPLVLGEPV SHPETIATAI 250
RIGSPASWTS AVEAQQQSKG RFLAATDEEI LAAYHLVARA EGVFVEPASA 300
ASIAGLLKAI DGGWVARGST VVCTITGNGL KDPDTALKDM PSVSPVPVDA 350
VAVVEQLGLV 360
Length:360
Mass (Da):37,385
Last modified:November 1, 1995 - v1
Checksum:i96A06F7B17B2688B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15186 Genomic DNA. Translation: AAA63090.1.
AL583920 Genomic DNA. Translation: CAC31511.1.
PIRiT09991.
RefSeqiNP_301824.1. NC_002677.1.
WP_010908148.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31511; CAC31511; CAC31511.
GeneIDi910224.
KEGGimle:ML1130.
PATRICi18054215. VBIMycLep78757_2052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15186 Genomic DNA. Translation: AAA63090.1 .
AL583920 Genomic DNA. Translation: CAC31511.1 .
PIRi T09991.
RefSeqi NP_301824.1. NC_002677.1.
WP_010908148.1. NC_002677.1.

3D structure databases

ProteinModelPortali P45837.
SMRi P45837. Positions 10-358.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML1130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31511 ; CAC31511 ; CAC31511 .
GeneIDi 910224.
KEGGi mle:ML1130.
PATRICi 18054215. VBIMycLep78757_2052.

Organism-specific databases

Lepromai ML1130.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000076503.
KOi K01733.
OMAi DPDWAVA.
OrthoDBi EOG6HMX9M.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF038945. Thr_synthase. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiTHRC_MYCLE
AccessioniPrimary (citable) accession number: P45837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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