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P45837

- THRC_MYCLE

UniProt

P45837 - THRC_MYCLE

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Protein

Threonine synthase

Gene

thrC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Pyridoxal phosphateBy similarity
Binding sitei326 – 3261Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:ML1130
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Threonine synthasePRO_0000185636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1130.

Structurei

3D structure databases

ProteinModelPortaliP45837.
SMRiP45837. Positions 10-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 2005Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
KOiK01733.
OMAiDPDWAVA.
OrthoDBiEOG6HMX9M.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45837-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGQQTTTHQ PWPGVIAAYR DRLPVGDDWT PVTLLEGGTP LIAAPRLSEQ
60 70 80 90 100
TGCTIHLKVE GLNPTGSFKD RGMTMAVTDA LARGQRAVLC ASTGNTSASA
110 120 130 140 150
AAYAARAGIT CAVLIPQGKI AMGKLAQAVM HGAKIIQIDG NFDDCLELAR
160 170 180 190 200
KMAADFPMIS LVNSVNPVRI EGQKTAVFEI VDALGTAPHV HALPVGNAGN
210 220 230 240 250
ITAYWKGYTE YHADGLIDRL PRMLGTQAAG AAPLVLGEPV SHPETIATAI
260 270 280 290 300
RIGSPASWTS AVEAQQQSKG RFLAATDEEI LAAYHLVARA EGVFVEPASA
310 320 330 340 350
ASIAGLLKAI DGGWVARGST VVCTITGNGL KDPDTALKDM PSVSPVPVDA
360
VAVVEQLGLV
Length:360
Mass (Da):37,385
Last modified:November 1, 1995 - v1
Checksum:i96A06F7B17B2688B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63090.1.
AL583920 Genomic DNA. Translation: CAC31511.1.
PIRiT09991.
RefSeqiNP_301824.1. NC_002677.1.
WP_010908148.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31511; CAC31511; CAC31511.
GeneIDi910224.
KEGGimle:ML1130.
PATRICi18054215. VBIMycLep78757_2052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63090.1 .
AL583920 Genomic DNA. Translation: CAC31511.1 .
PIRi T09991.
RefSeqi NP_301824.1. NC_002677.1.
WP_010908148.1. NC_002677.1.

3D structure databases

ProteinModelPortali P45837.
SMRi P45837. Positions 10-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31511 ; CAC31511 ; CAC31511 .
GeneIDi 910224.
KEGGi mle:ML1130.
PATRICi 18054215. VBIMycLep78757_2052.

Organism-specific databases

Lepromai ML1130.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000076503.
KOi K01733.
OMAi DPDWAVA.
OrthoDBi EOG6HMX9M.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF038945. Thr_synthase. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiTHRC_MYCLE
AccessioniPrimary (citable) accession number: P45837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3