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Protein

Homoserine kinase

Gene

thrB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (ask)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 106ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:ML1131
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1131.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001565881 – 315Homoserine kinaseAdd BLAST315

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1131.

Structurei

3D structure databases

ProteinModelPortaliP45836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5I. Bacteria.
COG0083. LUCA.
HOGENOMiHOG000247199.
KOiK00872.
OMAiCANRIPH.
OrthoDBiPOG091H020X.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTWMLPAGL VASAVVAASS ANLGPGFDSI GLALSLCDEI VVETTDSGLV
60 70 80 90 100
VVVDGEGADQ VPMGPEHLVV RAVRRGLQAV GVSAAGLVVR CRNAIPHSRG
110 120 130 140 150
LGSSAAAVVG GLAVVNGFVA QIDSTPLSNA QLIQLASEFE GHPDNAAAAV
160 170 180 190 200
LGGAVVSWVD RSYDQPDYCA VPLRLHPDIH LFAAIPEERS STAESRVLLP
210 220 230 240 250
ARVSHDDARF NVSRAALLVV ALTERPDLLM AATEDVLHQP HRASAMSASA
260 270 280 290 300
EYLRLLRRHN VAATLSGAGP SLIALSTQSE LPREAAEYGA ANGFIIIKMT
310
AGDEVCWRPE VTVPG
Length:315
Mass (Da):32,752
Last modified:April 27, 2001 - v2
Checksum:i08EA78DE4B17398A
GO

Sequence cautioni

The sequence AAA63100 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63100.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31512.1.
PIRiE87050.
T09990.
RefSeqiNP_301825.1. NC_002677.1.
WP_010908149.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31512; CAC31512; CAC31512.
GeneIDi910225.
KEGGimle:ML1131.
PATRICi18054217. VBIMycLep78757_2053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15186 Genomic DNA. Translation: AAA63100.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31512.1.
PIRiE87050.
T09990.
RefSeqiNP_301825.1. NC_002677.1.
WP_010908149.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP45836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31512; CAC31512; CAC31512.
GeneIDi910225.
KEGGimle:ML1131.
PATRICi18054217. VBIMycLep78757_2053.

Organism-specific databases

LepromaiML1131.

Phylogenomic databases

eggNOGiENOG4105D5I. Bacteria.
COG0083. LUCA.
HOGENOMiHOG000247199.
KOiK00872.
OMAiCANRIPH.
OrthoDBiPOG091H020X.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKHSE_MYCLE
AccessioniPrimary (citable) accession number: P45836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.