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P45820

- HUR1_YEAST

UniProt

P45820 - HUR1_YEAST

Protein

Putative uncharacterized protein HUR1

Gene

HUR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein predictedi
  1. Functioni

    GO - Biological processi

    1. DNA replication Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30656-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uncharacterized protein HUR1
    Gene namesi
    Name:HUR1
    Ordered Locus Names:YGL168W
    ORF Names:G1663
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    SGDiS000003136. HUR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No increased sensitivity to hydroxyurea.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 110110Putative uncharacterized protein HUR1PRO_0000202728Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP45820.

    Interactioni

    Protein-protein interaction databases

    BioGridi33086. 193 interactions.
    DIPiDIP-4765N.
    MINTiMINT-556496.
    STRINGi4932.YGL168W.

    Structurei

    3D structure databases

    ProteinModelPortaliP45820.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3417HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OMAiHIIANMA.
    OrthoDBiEOG7J70TW.

    Sequencei

    Sequence statusi: Complete.

    P45820-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFILVSVVNI CTYIHLHMFP LISTFTSIGL GVLMKDKGKE GKTIKAQNVT    50
    YQTFEKYVES SSFFFLVHNF LNSSTMKTLL LMSNNNSISE IPSFSVLKIL 100
    WKNGIYIAHI 110
    Length:110
    Mass (Da):12,515
    Last modified:November 1, 1995 - v1
    Checksum:i304BF9E60B4F09C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85757 Genomic DNA. Translation: CAA59761.1.
    Z72690 Genomic DNA. Translation: CAA96879.1.
    BK006941 Genomic DNA. Translation: DAA07945.1.
    PIRiS59652.
    RefSeqiNP_011347.1. NM_001181033.1.

    Genome annotation databases

    EnsemblFungiiYGL168W; YGL168W; YGL168W.
    GeneIDi852708.
    KEGGisce:YGL168W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85757 Genomic DNA. Translation: CAA59761.1 .
    Z72690 Genomic DNA. Translation: CAA96879.1 .
    BK006941 Genomic DNA. Translation: DAA07945.1 .
    PIRi S59652.
    RefSeqi NP_011347.1. NM_001181033.1.

    3D structure databases

    ProteinModelPortali P45820.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33086. 193 interactions.
    DIPi DIP-4765N.
    MINTi MINT-556496.
    STRINGi 4932.YGL168W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL168W ; YGL168W ; YGL168W .
    GeneIDi 852708.
    KEGGi sce:YGL168W.

    Organism-specific databases

    SGDi S000003136. HUR1.

    Phylogenomic databases

    OMAi HIIANMA.
    OrthoDBi EOG7J70TW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30656-MONOMER.

    Miscellaneous databases

    NextBioi 972067.

    Gene expression databases

    Genevestigatori P45820.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae."
      Klima R., Coglievina M., Zaccaria P., Bertani I., Bruschi C.V.
      Yeast 12:1033-1040(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin."
      Zewail A., Xie M.W., Xing Y., Lin L., Zhang P.F., Zou W., Saxe J.P., Huang J.
      Proc. Natl. Acad. Sci. U.S.A. 100:3345-3350(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    5. "Novel roles for selected genes in meiotic DNA processing."
      Jordan P.W., Klein F., Leach D.R.
      PLoS Genet. 3:E222-E222(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: CORRECTION TO DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiHUR1_YEAST
    AccessioniPrimary (citable) accession number: P45820
    Secondary accession number(s): D6VTY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    Deletion HUR1 has been reported to cause increased sensitivity to hydroxyurea (PubMed:12615994). However, HUR1 partially overlaps with PMR1 and a later analysis revealed that deletion of PMR1 but not HUR1 affected resistance to hydroxyurea (PubMed:18069899).2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3