P45820 (HUR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein HUR1

Gene names

Name:	HUR1
Ordered Locus Names:	YGL168W
ORF Names:	G1663

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Disruption phenotype	No increased sensitivity to hydroxyurea. Ref.4 Ref.5
Caution	Deletion HUR1 has been reported to cause increased sensitivity to hydroxyurea (Ref.4). However, HUR1 partially overlaps with PMR1 and a later analysis revealed that deletion of PMR1 but not HUR1 affected resistance to hydroxyurea (Ref.5).

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	Putative uncharacterized protein HUR1		PRO_0000202728
Regions
	Transmembrane	18 – 34	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P45820 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 304BF9E60B4F09C4	FASTA	110	12,515
	10 20 30 40 50 60 MFILVSVVNI CTYIHLHMFP LISTFTSIGL GVLMKDKGKE GKTIKAQNVT YQTFEKYVES 70 80 90 100 110 SSFFFLVHNF LNSSTMKTLL LMSNNNSISE IPSFSVLKIL WKNGIYIAHI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae." Klima R., Coglievina M., Zaccaria P., Bertani I., Bruschi C.V. Yeast 12:1033-1040(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K. Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin." Zewail A., Xie M.W., Xing Y., Lin L., Zhang P.F., Zou W., Saxe J.P., Huang J. Proc. Natl. Acad. Sci. U.S.A. 100:3345-3350(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[5]	"Novel roles for selected genes in meiotic DNA processing." Jordan P.W., Klein F., Leach D.R. PLoS Genet. 3:E222-E222(2007) [PubMed] [Europe PMC] [Abstract] Cited for: CORRECTION TO DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85757 Genomic DNA. Translation: CAA59761.1. Z72690 Genomic DNA. Translation: CAA96879.1. BK006941 Genomic DNA. Translation: DAA07945.1.
PIR	S59652.
RefSeq	NP_011347.1. NM_001181033.1.
3D structure databases
ProteinModelPortal	P45820.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4765N.
MINT	MINT-556496.
STRING	4932.YGL168W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YGL168W; YGL168W; YGL168W.
GeneID	852708.
KEGG	sce:YGL168W.
Organism-specific databases
SGD	S000003136. HUR1.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30656-MONOMER.
Gene expression databases
Genevestigator	P45820.
GermOnline	YGL168W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	972067.

Entry information

Entry name

HUR1_YEAST

Accession

Primary (citable) accession number: P45820
Secondary accession number(s): D6VTY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program