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Protein

SEC14 cytosolic factor

Gene

SEC14

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14 cytosolic factor
Alternative name(s):
Phosphatidylinositol/phosphatidylcholine transfer protein
Short name:
PI/PC TP
Gene namesi
Name:SEC14
Ordered Locus Names:YALI0D04488g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492SEC14 cytosolic factorPRO_0000210743Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP45816.
SMRiP45816. Positions 5-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 271174CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi324 – 437114Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP45816.
OMAiECTNEER.
OrthoDBiEOG761C55.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTEQEFLA SYPQKVAPGG PTGYPGNLTA EQEQKLGELK MILLTKGYED
60 70 80 90 100
RTDDATLLRF LRARKFDVPL AQEMWENCEK WRKEFGTNTI LEDFWYKEKK
110 120 130 140 150
EVAKLYPQYY HKTDKDGRPV YVENVGKVNI HEMYKITTQE RMLRNLVWEY
160 170 180 190 200
ESFVRHRLPA CSRVVGHLIE TSCTILDLKG VSLSSASQVY GFLKDASNIG
210 220 230 240 250
QNYYPERMGK FYLINAPFGF STVFSVIKRF LDPVTVSKIH VYGSNYKEKL
260 270 280 290 300
LAQVPAYNLP IKFGGQSSSK IGVELSDDGP WRDPQFVGPE GLAPVAGERP
310 320 330 340 350
TGAPSIVSNS STYAKSTAST KVGADDKATD AKANGNGAAA AAAGAGTAAA
360 370 380 390 400
GGAAAAAGAS SSKQAAPAQA APAQAAKAPV PAAAKTATAP APTGKTAAPQ
410 420 430 440 450
TNSFPPEMLA MMEQNEKKAE KAAEAKTKGG AAPQANAFTD EQLAQLNSLP
460 470 480 490
QQVATGGVSQ PLPDSHVTQG VPTVAKIAEA AAGPHEDAHL PH
Length:492
Mass (Da):52,607
Last modified:October 11, 2004 - v2
Checksum:iC64278E9B6A0113C
GO

Sequence cautioni

The sequence AAA35249.1 differs from that shown. Reason: Frameshift at positions 291, 403 and 480. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20972 Genomic DNA. Translation: AAA35249.1. Frameshift.
CR382130 Genomic DNA. Translation: CAG80595.1.
PIRiS43745.
RefSeqiXP_502407.1. XM_502407.1.

Genome annotation databases

EnsemblFungiiCAG80595; CAG80595; YALI0_D04488g.
GeneIDi2910641.
KEGGiyli:YALI0D04488g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20972 Genomic DNA. Translation: AAA35249.1. Frameshift.
CR382130 Genomic DNA. Translation: CAG80595.1.
PIRiS43745.
RefSeqiXP_502407.1. XM_502407.1.

3D structure databases

ProteinModelPortaliP45816.
SMRiP45816. Positions 5-294.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG80595; CAG80595; YALI0_D04488g.
GeneIDi2910641.
KEGGiyli:YALI0D04488g.

Phylogenomic databases

InParanoidiP45816.
OMAiECTNEER.
OrthoDBiEOG761C55.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A phosphatidylinositol/phosphatidylcholine transfer protein is required for differentiation of the dimorphic yeast Yarrowia lipolytica from the yeast to the mycelial form."
    Lopez M.C., Nicaud J.-M., Skinner H.B., Vergnolle C., Kader J.-C., Bankaitis V., Gaillardin C.
    J. Cell Biol. 125:113-127(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiSEC14_YARLI
AccessioniPrimary (citable) accession number: P45816
Secondary accession number(s): Q6CAA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: January 20, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.