Copper resistance protein CRF1 - Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Copper resistance protein CRF1

Alternative name(s):
YlCRF1

Gene names

Name:	CRF1
Ordered Locus Names:	YALI0B08206g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia ›

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Transcriptional regulator involved in resistance to high copper concentration. Ref.1
Subcellular location	Nucleus Ref.1.
Sequence similarities	Contains 1 copper-fist DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Copper DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 411

411

Copper resistance protein CRF1

PRO_0000194932

Regions

DNA binding

1 – 40

40

Copper-fist

Compositional bias

63 – 66

4

Poly-Ser

Compositional bias

126 – 140

15

Poly-Gln

Compositional bias

205 – 211

7

Poly-Ser

Sites

Metal binding

11

1

Zinc By similarity

Metal binding

14

1

Zinc By similarity

Metal binding

23

1

Zinc By similarity

Metal binding

25

1

Zinc By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P45815 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9AD602FA467EACC7
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FASTA

411

43,689

        10         20         30         40         50         60 
MVVIEGIKYA CERCIRGHRV SSCTHTQQPL IRIKPKGRPA TQCLHCREAR KNKALHVKCK 

        70         80         90        100        110        120 
CGSSSSKHAA TCPCYSGGGC ICTNKHPQVL PPNSTTTGAN GCIVINKAVL DEGSQQQAQQ 

       130        140        150        160        170        180 
AQQQSQSQQA QQQQQQPQPQ ASPILQQPQM PTPVHTTNVT TPPVATPTHS HRALSTTPSL 

       190        200        210        220        230        240 
SPQPQSPHSP ESALKSVNFL GRTNSSSSLS SLHSGRNKNR IEKVRPSHNS LSAASQLANS 

       250        260        270        280        290        300 
PSSPFYAVTP PAWVDSPTLV PTGALDASYL QILNDDLSSP LLDSDVFSSL DMEPVAHSNN 

       310        320        330        340        350        360 
NHGGIPTGGS RALASTDINF DRFESTSPSS ILSSWNLWGG VGGSDAPEMS VAANPSASAS 

       370        380        390        400        410 
ASSIQTPPSS NATPEWVQGQ QQPCSVSPAD VMLPFKRDDQ ESVFLTEPLY L

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A copper-responsive transcription factor, CRF1, mediates copper and cadmium resistance in Yarrowia lipolytica." Garcia S., Prado-Gonzalez M., Degano R., Dominguez A. J. Biol. Chem. 277:37359-37368(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z23265 Genomic DNA. Translation: CAA80803.1. CR382128 Genomic DNA. Translation: CAG82873.1.
RefSeq	XP_500631.1. XM_500631.1.
3D structure databases
ProteinModelPortal	P45815.
SMR	P45815. Positions 1-41.
ModBase	Search...
Protein-protein interaction databases
STRING	4952.P45815.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2907407.
KEGG	yli:YALI0B08206g.
Phylogenomic databases
eggNOG	NOG71500.
OrthoDB	EOG4X0R35.
Family and domain databases
Gene3D	3.90.430.10. 1 hit.
InterPro	IPR001083. Cu_fist_DNA-bd. [Graphical view]
Pfam	PF00649. Copper-fist. 1 hit. [Graphical view]
PRINTS	PR00617. COPPERFIST.
SMART	SM00412. Cu_FIST. 1 hit. [Graphical view]
SUPFAM	SSF57879. Cu_fist_DNA_bd. 1 hit.
PROSITE	PS01119. COPPER_FIST_1. 1 hit. PS50073. COPPER_FIST_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRF1_YARLI

Accession

Primary (citable) accession number: P45815

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents