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Protein

Putative membrane protein IgaA homolog

Gene

yrfF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7741-MONOMER.
ECOL316407:JW3361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative membrane protein IgaA homolog
Gene namesi
Name:yrfF
Ordered Locus Names:b3398, JW3361
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12927. yrfF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1PeriplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 204CytoplasmicSequence analysisAdd BLAST182
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 339CytoplasmicSequence analysisAdd BLAST93
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 655PeriplasmicSequence analysisAdd BLAST295
Transmembranei656 – 676HelicalSequence analysisAdd BLAST21
Topological domaini677 – 711CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150141 – 711Putative membrane protein IgaA homologAdd BLAST711

Proteomic databases

PaxDbiP45800.
PRIDEiP45800.

Interactioni

Protein-protein interaction databases

DIPiDIP-12922N.
IntActiP45800. 2 interactors.
STRINGi511145.b3398.

Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 44Combined sources4
Helixi47 – 62Combined sources16
Helixi83 – 86Combined sources4
Beta strandi87 – 93Combined sources7
Beta strandi95 – 98Combined sources4
Beta strandi103 – 107Combined sources5
Beta strandi109 – 112Combined sources4
Beta strandi115 – 118Combined sources4
Turni124 – 126Combined sources3
Beta strandi129 – 137Combined sources9
Beta strandi139 – 147Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UZMNMR-A36-154[»]
ProteinModelPortaliP45800.
SMRiP45800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IgaA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQY. Bacteria.
ENOG410XNRW. LUCA.
HOGENOMiHOG000125564.
OMAiDLIYPPH.

Family and domain databases

InterProiIPR010771. IgaA.
[Graphical view]
PfamiPF07095. IgaA. 1 hit.
[Graphical view]
ProDomiPD147088. IgaA. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P45800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIVIFLAA LLACSLLAGW LIKVRSRRRQ LPWTNAFADA QTRKLTPEER
60 70 80 90 100
SAVENYLESL TQVLQVPGPT GASAAPISLA LNAESNNVMM LTHAITRYGI
110 120 130 140 150
STDDPNKWRY YLDSVEVHLP PFWEQYINDE NTVELIHTDS LPLVISLNGH
160 170 180 190 200
TLQEYMQETR SYALQPVPST QASIRGEESE QIELLNIRKE THEEYALSRP
210 220 230 240 250
RGLREALLIV ASFLMFFFCL ITPDVFVPWL AGGALLLLGA GLWGLFAPPA
260 270 280 290 300
KSSLREIHCL RGTPRRWGLF GENDQEQINN ISLGIIDLVY PAHWQPYIAQ
310 320 330 340 350
DLGQQTDIDI YLDRHVVRQG RYLSLHDEVK NFPLQHWLRS TIIAAGSLLV
360 370 380 390 400
LFMLLFWIPL DMPLKFTLSW MKGAQTIEAT SVKQLADAGV RVGDTLRISG
410 420 430 440 450
TGMCNIRTSG TWSAKTNSPF LPFDCSQIIW NDARSLPLPE SELVNKATAL
460 470 480 490 500
TEAVNRQLHP KPEDESRVSA SLRSAIQKSG MVLLDDFGDI VLKTADLCSA
510 520 530 540 550
KDDCVRLKNA LVNLGNSKDW DALVKRANAG KLDGVNVLLR PVSAESLDNL
560 570 580 590 600
VATSTAPFIT HETARAAQSL NSPAPGGFLI VSDEGSDFVD QPWPSASLYD
610 620 630 640 650
YPPQEQWNAF QKLAQMLMHT PFNAEGIVTK IFTDANGTQH IGLHPIPDRS
660 670 680 690 700
GLWRYLSTTL LLLTMLGSAI YNGVQAWRRY QRHRTRMMEI QAYYESCLNP
710
QLITPSESLI E
Length:711
Mass (Da):79,490
Last modified:November 1, 1995 - v1
Checksum:iC9222D0F3403BA03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58195.1.
U00096 Genomic DNA. Translation: AAC76423.1.
AP009048 Genomic DNA. Translation: BAE77893.1.
PIRiA65135.
RefSeqiNP_417857.1. NC_000913.3.
WP_000104533.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76423; AAC76423; b3398.
BAE77893; BAE77893; BAE77893.
GeneIDi947905.
KEGGiecj:JW3361.
eco:b3398.
PATRICi32122230. VBIEscCol129921_3492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58195.1.
U00096 Genomic DNA. Translation: AAC76423.1.
AP009048 Genomic DNA. Translation: BAE77893.1.
PIRiA65135.
RefSeqiNP_417857.1. NC_000913.3.
WP_000104533.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UZMNMR-A36-154[»]
ProteinModelPortaliP45800.
SMRiP45800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-12922N.
IntActiP45800. 2 interactors.
STRINGi511145.b3398.

Proteomic databases

PaxDbiP45800.
PRIDEiP45800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76423; AAC76423; b3398.
BAE77893; BAE77893; BAE77893.
GeneIDi947905.
KEGGiecj:JW3361.
eco:b3398.
PATRICi32122230. VBIEscCol129921_3492.

Organism-specific databases

EchoBASEiEB2763.
EcoGeneiEG12927. yrfF.

Phylogenomic databases

eggNOGiENOG4105DQY. Bacteria.
ENOG410XNRW. LUCA.
HOGENOMiHOG000125564.
OMAiDLIYPPH.

Enzyme and pathway databases

BioCyciEcoCyc:G7741-MONOMER.
ECOL316407:JW3361-MONOMER.

Miscellaneous databases

PROiP45800.

Family and domain databases

InterProiIPR010771. IgaA.
[Graphical view]
PfamiPF07095. IgaA. 1 hit.
[Graphical view]
ProDomiPD147088. IgaA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiIGAA_ECOLI
AccessioniPrimary (citable) accession number: P45800
Secondary accession number(s): Q2M763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.