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Protein

Type II secretion system protein C

Gene

epsC

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein secretion Source: TIGR
  • protein secretion by the type II secretion system Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciVCHO:VC2734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein C
Short name:
T2SS protein C
Alternative name(s):
Cholera toxin secretion protein EpsC
General secretion pathway protein C
Gene namesi
Name:epsC
Ordered Locus Names:VC_2734
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 305PeriplasmicSequence analysisAdd BLAST255

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150051 – 305Type II secretion system protein CAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2734.

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi204 – 216Combined sources13
Helixi218 – 220Combined sources3
Helixi221 – 223Combined sources3
Beta strandi225 – 232Combined sources8
Beta strandi235 – 243Combined sources9
Helixi247 – 252Combined sources6
Beta strandi260 – 264Combined sources5
Helixi272 – 280Combined sources9
Helixi281 – 284Combined sources4
Beta strandi286 – 294Combined sources9
Beta strandi297 – 304Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I4SX-ray1.92A/B204-305[»]
2I6VX-ray1.63A219-305[»]
ProteinModelPortaliP45777.
SMRiP45777.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45777.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108XKW. Bacteria.
COG3031. LUCA.
KOiK02452.
OMAiIANRGKQ.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
PRINTSiPR00810. BCTERIALGSPC.
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKQLPPLA AWPRLLSQNT LRWQKPISEG LTLLLLVASA WTLGKMVWVV
60 70 80 90 100
SAEQTPVPTW SPTLSGLKAE RQPLDISVLQ KGELFGVFTE PKEAPVVEQP
110 120 130 140 150
VVVDAPKTRL SLVLSGVVAS NDAQKSLAVI ANRGVQATYG INEVIEGTQA
160 170 180 190 200
KLKAVMPDRV IISNSGRDET LMLEGLDYTA PATASVSNPP RPRPNQPNAV
210 220 230 240 250
PQFEDKVDAI REAIARNPQE IFQYVRLSQV KRDDKVLGYR VSPGKDPVLF
260 270 280 290 300
ESIGLQDGDM AVALNGLDLT DPNVMNTLFQ SMNEMTEMSL TVERDGQQHD

VYIQF
Length:305
Mass (Da):33,585
Last modified:December 1, 2000 - v2
Checksum:i9D760097CDEF7066
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44G → A in AAA58784 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58784.1.
AE003852 Genomic DNA. Translation: AAF95873.1.
PIRiG82041.
RefSeqiNP_232360.1. NC_002505.1.
WP_000394676.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95873; AAF95873; VC_2734.
GeneIDi2614897.
KEGGivch:VC2734.
PATRICi20084488. VBIVibCho83274_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58784.1.
AE003852 Genomic DNA. Translation: AAF95873.1.
PIRiG82041.
RefSeqiNP_232360.1. NC_002505.1.
WP_000394676.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I4SX-ray1.92A/B204-305[»]
2I6VX-ray1.63A219-305[»]
ProteinModelPortaliP45777.
SMRiP45777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2734.

Protocols and materials databases

DNASUi2614897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95873; AAF95873; VC_2734.
GeneIDi2614897.
KEGGivch:VC2734.
PATRICi20084488. VBIVibCho83274_2610.

Phylogenomic databases

eggNOGiENOG4108XKW. Bacteria.
COG3031. LUCA.
KOiK02452.
OMAiIANRGKQ.

Enzyme and pathway databases

BioCyciVCHO:VC2734-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP45777.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
PRINTSiPR00810. BCTERIALGSPC.
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPC_VIBCH
AccessioniPrimary (citable) accession number: P45777
Secondary accession number(s): Q9KNK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.