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Protein

Type II secretion system protein C

Gene

epsC

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein secretion Source: TIGR
  • protein secretion by the type II secretion system Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciVCHO:VC2734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein C
Short name:
T2SS protein C
Alternative name(s):
Cholera toxin secretion protein EpsC
General secretion pathway protein C
Gene namesi
Name:epsC
Ordered Locus Names:VC_2734
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence analysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Topological domaini51 – 305255PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Type II secretion system protein CPRO_0000215005Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2734.

Structurei

Secondary structure

1
305
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi204 – 21613Combined sources
Helixi218 – 2203Combined sources
Helixi221 – 2233Combined sources
Beta strandi225 – 2328Combined sources
Beta strandi235 – 2439Combined sources
Helixi247 – 2526Combined sources
Beta strandi260 – 2645Combined sources
Helixi272 – 2809Combined sources
Helixi281 – 2844Combined sources
Beta strandi286 – 2949Combined sources
Beta strandi297 – 3048Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I4SX-ray1.92A/B204-305[»]
2I6VX-ray1.63A219-305[»]
ProteinModelPortaliP45777.
SMRiP45777. Positions 204-305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45777.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108XKW. Bacteria.
COG3031. LUCA.
KOiK02452.
OMAiIANRGKQ.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
PRINTSiPR00810. BCTERIALGSPC.
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKQLPPLA AWPRLLSQNT LRWQKPISEG LTLLLLVASA WTLGKMVWVV
60 70 80 90 100
SAEQTPVPTW SPTLSGLKAE RQPLDISVLQ KGELFGVFTE PKEAPVVEQP
110 120 130 140 150
VVVDAPKTRL SLVLSGVVAS NDAQKSLAVI ANRGVQATYG INEVIEGTQA
160 170 180 190 200
KLKAVMPDRV IISNSGRDET LMLEGLDYTA PATASVSNPP RPRPNQPNAV
210 220 230 240 250
PQFEDKVDAI REAIARNPQE IFQYVRLSQV KRDDKVLGYR VSPGKDPVLF
260 270 280 290 300
ESIGLQDGDM AVALNGLDLT DPNVMNTLFQ SMNEMTEMSL TVERDGQQHD

VYIQF
Length:305
Mass (Da):33,585
Last modified:December 1, 2000 - v2
Checksum:i9D760097CDEF7066
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → A in AAA58784 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58784.1.
AE003852 Genomic DNA. Translation: AAF95873.1.
PIRiG82041.
RefSeqiNP_232360.1. NC_002505.1.
WP_000394676.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95873; AAF95873; VC_2734.
GeneIDi2614897.
KEGGivch:VC2734.
PATRICi20084488. VBIVibCho83274_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58784.1.
AE003852 Genomic DNA. Translation: AAF95873.1.
PIRiG82041.
RefSeqiNP_232360.1. NC_002505.1.
WP_000394676.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I4SX-ray1.92A/B204-305[»]
2I6VX-ray1.63A219-305[»]
ProteinModelPortaliP45777.
SMRiP45777. Positions 204-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2734.

Protocols and materials databases

DNASUi2614897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95873; AAF95873; VC_2734.
GeneIDi2614897.
KEGGivch:VC2734.
PATRICi20084488. VBIVibCho83274_2610.

Phylogenomic databases

eggNOGiENOG4108XKW. Bacteria.
COG3031. LUCA.
KOiK02452.
OMAiIANRGKQ.

Enzyme and pathway databases

BioCyciVCHO:VC2734-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP45777.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
PRINTSiPR00810. BCTERIALGSPC.
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPC_VIBCH
AccessioniPrimary (citable) accession number: P45777
Secondary accession number(s): Q9KNK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.