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Protein

Type II secretion system protein G

Gene

epsG

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.

GO - Molecular functioni

GO - Biological processi

  • protein secretion Source: TIGR
  • protein secretion by the type II secretion system Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciVCHO:VC2730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II secretion system protein G
Short name:
T2SS protein G
Alternative name(s):
Cholera toxin secretion protein EpsG
General secretion pathway protein G
Gene namesi
Name:epsG
Ordered Locus Names:VC_2730
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99By similarityPRO_0000024210
Chaini10 – 146137Type II secretion system protein GPRO_0000024211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101N-methylphenylalaninePROSITE-ProRule annotation

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2730.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 6328Combined sources
Turni69 – 713Combined sources
Helixi73 – 764Combined sources
Beta strandi93 – 964Combined sources
Beta strandi107 – 1115Combined sources
Beta strandi113 – 1219Combined sources
Turni123 – 1264Combined sources
Beta strandi127 – 1293Combined sources
Helixi132 – 1343Combined sources
Helixi139 – 1457Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FU1X-ray1.90A/B35-146[»]
4LW9X-ray1.90A/B/C/D/E/F/I/J/K/L/Q/R35-146[»]
ProteinModelPortaliP45773.
SMRiP45773. Positions 35-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45773.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP G family.Curated

Phylogenomic databases

eggNOGiCOG2165.
KOiK02456.
OMAiDIGNWNM.
OrthoDBiEOG657JHX.

Family and domain databases

InterProiIPR000983. Bac_GSPG_pilin.
IPR012902. N_methyl_site.
IPR013545. T2SS_protein-G.
IPR010054. Type2_sec_GspG.
[Graphical view]
PfamiPF13544. N_methyl_2. 1 hit.
PF08334. T2SG. 1 hit.
[Graphical view]
PRINTSiPR00813. BCTERIALGSPG.
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
TIGR01710. typeII_sec_gspG. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKMRKQTGF TLLEVMVVVV ILGILASFVV PNLLGNKEKA DQQKAVTDIV
60 70 80 90 100
ALENALDMYK LDNSVYPTTD QGLEALVTKP TNPEPRNYRE GGYIKRLPKD
110 120 130 140
PWGNDYQYLS PGDKGTIDVF TLGADGQEGG EGTGADIGNW NIQDFQ
Length:146
Mass (Da):16,080
Last modified:November 1, 1995 - v1
Checksum:i2B211AA994761E2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58788.1.
AE003852 Genomic DNA. Translation: AAF95870.1.
PIRiD82041.
RefSeqiNP_232357.1. NC_002505.1.
WP_000738789.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95870; AAF95870; VC_2730.
GeneIDi2614893.
KEGGivch:VC2730.
PATRICi20084478. VBIVibCho83274_2605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33796 Genomic DNA. Translation: AAA58788.1.
AE003852 Genomic DNA. Translation: AAF95870.1.
PIRiD82041.
RefSeqiNP_232357.1. NC_002505.1.
WP_000738789.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FU1X-ray1.90A/B35-146[»]
4LW9X-ray1.90A/B/C/D/E/F/I/J/K/L/Q/R35-146[»]
ProteinModelPortaliP45773.
SMRiP45773. Positions 35-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2730.

Protocols and materials databases

DNASUi2614893.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95870; AAF95870; VC_2730.
GeneIDi2614893.
KEGGivch:VC2730.
PATRICi20084478. VBIVibCho83274_2605.

Phylogenomic databases

eggNOGiCOG2165.
KOiK02456.
OMAiDIGNWNM.
OrthoDBiEOG657JHX.

Enzyme and pathway databases

BioCyciVCHO:VC2730-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP45773.

Family and domain databases

InterProiIPR000983. Bac_GSPG_pilin.
IPR012902. N_methyl_site.
IPR013545. T2SS_protein-G.
IPR010054. Type2_sec_GspG.
[Graphical view]
PfamiPF13544. N_methyl_2. 1 hit.
PF08334. T2SG. 1 hit.
[Graphical view]
PRINTSiPR00813. BCTERIALGSPG.
TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
TIGR01710. typeII_sec_gspG. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the general secretion pathway genes in Vibrio cholerae."
    Overbye L.J.
    Thesis (1994), Michigan State University, United States
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: El Tor TRH7000.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiGSPG_VIBCH
AccessioniPrimary (citable) accession number: P45773
Secondary accession number(s): Q9JPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.