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P45773

- GSPG_VIBCH

UniProt

P45773 - GSPG_VIBCH

Protein

Type II secretion system protein G

Gene

epsG

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.

    GO - Molecular functioni

    1. protein transporter activity Source: InterPro

    GO - Biological processi

    1. protein secretion Source: TIGR
    2. protein secretion by the type II secretion system Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciVCHO:VC2730-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type II secretion system protein G
    Short name:
    T2SS protein G
    Alternative name(s):
    Cholera toxin secretion protein EpsG
    General secretion pathway protein G
    Gene namesi
    Name:epsG
    Ordered Locus Names:VC_2730
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. type II protein secretion system complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 99By similarityPRO_0000024210
    Chaini10 – 146137Type II secretion system protein GPRO_0000024211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101N-methylphenylalanineBy similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC2730.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 6328
    Turni69 – 713
    Helixi73 – 764
    Beta strandi93 – 964
    Beta strandi107 – 1115
    Beta strandi113 – 1219
    Turni123 – 1264
    Beta strandi127 – 1293
    Helixi132 – 1343
    Helixi139 – 1457

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FU1X-ray1.90A/B35-146[»]
    ProteinModelPortaliP45773.
    SMRiP45773. Positions 35-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP45773.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GSP G family.Curated

    Phylogenomic databases

    eggNOGiCOG2165.
    KOiK02456.
    OMAiDIGNWNM.
    OrthoDBiEOG657JHX.

    Family and domain databases

    InterProiIPR000983. Bac_GSPG_pilin.
    IPR012902. N_methyl_site.
    IPR013545. T2SS_protein-G.
    IPR010054. Type2_sec_GspG.
    [Graphical view]
    PfamiPF13544. N_methyl_2. 1 hit.
    PF08334. T2SG. 1 hit.
    [Graphical view]
    PRINTSiPR00813. BCTERIALGSPG.
    TIGRFAMsiTIGR02532. IV_pilin_GFxxxE. 1 hit.
    TIGR01710. typeII_sec_gspG. 1 hit.
    PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P45773-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKMRKQTGF TLLEVMVVVV ILGILASFVV PNLLGNKEKA DQQKAVTDIV    50
    ALENALDMYK LDNSVYPTTD QGLEALVTKP TNPEPRNYRE GGYIKRLPKD 100
    PWGNDYQYLS PGDKGTIDVF TLGADGQEGG EGTGADIGNW NIQDFQ 146
    Length:146
    Mass (Da):16,080
    Last modified:November 1, 1995 - v1
    Checksum:i2B211AA994761E2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33796 Genomic DNA. Translation: AAA58788.1.
    AE003852 Genomic DNA. Translation: AAF95870.1.
    PIRiD82041.
    RefSeqiNP_232357.1. NC_002505.1.
    WP_000738789.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF95870; AAF95870; VC_2730.
    GeneIDi2614893.
    KEGGivch:VC2730.
    PATRICi20084478. VBIVibCho83274_2605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33796 Genomic DNA. Translation: AAA58788.1 .
    AE003852 Genomic DNA. Translation: AAF95870.1 .
    PIRi D82041.
    RefSeqi NP_232357.1. NC_002505.1.
    WP_000738789.1. NC_002505.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FU1 X-ray 1.90 A/B 35-146 [» ]
    ProteinModelPortali P45773.
    SMRi P45773. Positions 35-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2730.

    Protocols and materials databases

    DNASUi 2614893.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF95870 ; AAF95870 ; VC_2730 .
    GeneIDi 2614893.
    KEGGi vch:VC2730.
    PATRICi 20084478. VBIVibCho83274_2605.

    Phylogenomic databases

    eggNOGi COG2165.
    KOi K02456.
    OMAi DIGNWNM.
    OrthoDBi EOG657JHX.

    Enzyme and pathway databases

    BioCyci VCHO:VC2730-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P45773.

    Family and domain databases

    InterProi IPR000983. Bac_GSPG_pilin.
    IPR012902. N_methyl_site.
    IPR013545. T2SS_protein-G.
    IPR010054. Type2_sec_GspG.
    [Graphical view ]
    Pfami PF13544. N_methyl_2. 1 hit.
    PF08334. T2SG. 1 hit.
    [Graphical view ]
    PRINTSi PR00813. BCTERIALGSPG.
    TIGRFAMsi TIGR02532. IV_pilin_GFxxxE. 1 hit.
    TIGR01710. typeII_sec_gspG. 1 hit.
    PROSITEi PS00409. PROKAR_NTER_METHYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization of the general secretion pathway genes in Vibrio cholerae."
      Overbye L.J.
      Thesis (1994), Michigan State University, United States
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: El Tor TRH7000.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiGSPG_VIBCH
    AccessioniPrimary (citable) accession number: P45773
    Secondary accession number(s): Q9JPZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3