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Protein

Inner membrane amino-acid ABC transporter permease protein YhdY

Gene

yhdY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHDY-MONOMER.
ECOL316407:JW5545-MONOMER.

Protein family/group databases

TCDBi3.A.1.3.26. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane amino-acid ABC transporter permease protein YhdY
Gene namesi
Name:yhdY
Ordered Locus Names:b3270, JW5545
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12836. yhdY.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini58 – 99PeriplasmicSequence analysisAdd BLAST42
Transmembranei100 – 120HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini121 – 125CytoplasmicSequence analysis5
Transmembranei126 – 146HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini147 – 162PeriplasmicSequence analysisAdd BLAST16
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini184 – 192CytoplasmicSequence analysis9
Transmembranei193 – 213HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini214 – 233PeriplasmicSequence analysisAdd BLAST20
Transmembranei234 – 254HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini255 – 291CytoplasmicSequence analysisAdd BLAST37
Transmembranei292 – 312HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini313 – 326PeriplasmicSequence analysisAdd BLAST14
Transmembranei327 – 347HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini348 – 367CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000602541 – 367Inner membrane amino-acid ABC transporter permease protein YhdYAdd BLAST367

Proteomic databases

PaxDbiP45768.
PRIDEiP45768.

Interactioni

Protein-protein interaction databases

BioGridi4261009. 8 interactors.
DIPiDIP-12306N.
IntActiP45768. 3 interactors.
MINTiMINT-1309860.
STRINGi511145.b3270.

Structurei

3D structure databases

ProteinModelPortaliP45768.
SMRiP45768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 353ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DRP. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000125341.
InParanoidiP45768.
KOiK09971.
OMAiLVFWVFC.
PhylomeDBiP45768.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVLLSHPP RPASHNSSRA MVWVRKNLFS SWSNSLLTIG CIWLMWELIP
60 70 80 90 100
PLLNWAFLQA NWVGSTRADC TKAGACWVFI HERFGQFMYG LYPHDQRWRI
110 120 130 140 150
NLALLIGLVS IAPMFWKILP HRGRYIAAWA VIYPLIVWWL MYGGFFALER
160 170 180 190 200
VETRQWGGLT LTLIIASVGI AGALPWGILL ALGRRSHMPI VRILSVIFIE
210 220 230 240 250
FWRGVPLITV LFMSSVMLPL FMAEGTSIDK LIRALVGVIL FQSAYVAEVV
260 270 280 290 300
RGGLQALPKG QYEAAESLAL GYWKTQGLVI LPQALKLVIP GLVNTIIALF
310 320 330 340 350
KDTSLVIIIG LFDLFSSVQQ ATVDPAWLGM STEGYVFAAL IYWIFCFSMS
360
RYSQYLEKRF NTGRTPH
Length:367
Mass (Da):41,484
Last modified:December 15, 1998 - v2
Checksum:iEC95E04BBC7418D1
GO

Sequence cautioni

The sequence AAA58074 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58074.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76302.2.
AP009048 Genomic DNA. Translation: BAE77311.1.
PIRiH65119.
RefSeqiNP_417736.2. NC_000913.3.
WP_001300681.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76302; AAC76302; b3270.
BAE77311; BAE77311; BAE77311.
GeneIDi947764.
KEGGiecj:JW5545.
eco:b3270.
PATRICi32121972. VBIEscCol129921_3370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58074.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76302.2.
AP009048 Genomic DNA. Translation: BAE77311.1.
PIRiH65119.
RefSeqiNP_417736.2. NC_000913.3.
WP_001300681.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45768.
SMRiP45768.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261009. 8 interactors.
DIPiDIP-12306N.
IntActiP45768. 3 interactors.
MINTiMINT-1309860.
STRINGi511145.b3270.

Protein family/group databases

TCDBi3.A.1.3.26. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP45768.
PRIDEiP45768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76302; AAC76302; b3270.
BAE77311; BAE77311; BAE77311.
GeneIDi947764.
KEGGiecj:JW5545.
eco:b3270.
PATRICi32121972. VBIEscCol129921_3370.

Organism-specific databases

EchoBASEiEB2685.
EcoGeneiEG12836. yhdY.

Phylogenomic databases

eggNOGiENOG4105DRP. Bacteria.
COG0765. LUCA.
HOGENOMiHOG000125341.
InParanoidiP45768.
KOiK09971.
OMAiLVFWVFC.
PhylomeDBiP45768.

Enzyme and pathway databases

BioCyciEcoCyc:YHDY-MONOMER.
ECOL316407:JW5545-MONOMER.

Miscellaneous databases

PROiP45768.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYHDY_ECOLI
AccessioniPrimary (citable) accession number: P45768
Secondary accession number(s): Q2M8U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.