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Protein

Putative type II secretion system protein L

Gene

gspL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7711-MONOMER.
ECOL316407:JW5705-MONOMER.
MetaCyc:G7711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein L
Short name:
T2SS protein L
Alternative name(s):
Putative general secretion pathway protein L
Gene namesi
Name:gspL
Synonyms:yheK
Ordered Locus Names:b3333, JW5705
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12895. gspL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei242 – 26019HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Putative type II secretion system protein LPRO_0000207314Add
BLAST

Proteomic databases

PaxDbiP45763.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263437. 79 interactions.
STRINGi511145.b3333.

Structurei

3D structure databases

ProteinModelPortaliP45763.
SMRiP45763. Positions 5-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG41063JA. Bacteria.
COG3297. LUCA.
HOGENOMiHOG000125386.
KOiK02461.
OMAiHEASGRW.

Family and domain databases

InterProiIPR024230. GspL_cyto_dom.
IPR025691. GspL_pp_dom.
IPR007812. T2SS_protein-L.
[Graphical view]
PfamiPF12693. GspL_C. 1 hit.
PF05134. T2SSL. 1 hit.
[Graphical view]
PIRSFiPIRSF015761. Protein_L. 1 hit.
TIGRFAMsiTIGR01709. typeII_sec_gspL. 1 hit.

Sequencei

Sequence statusi: Complete.

P45763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPESLMVIRS SSTLRKHWEW MTFSADSVSS VHTLTDDLPL ESLADQPGAG
60 70 80 90 100
NVHLLIPPEG LLYRSLTLPN AKYKLTAQTL QWLAEETLPD NTQDWHWTVV
110 120 130 140 150
DKQNESVEVI GIQSEKLSRY LERLHTAGLN VTRVLPDGCY LPWEVDSWTL
160 170 180 190 200
VNQQTSWLIR SAAHAFNELD EHWLQHLAAQ FPPENMLCYG VVPHGVAAAN
210 220 230 240 250
PLIQHPEIPS LSLYSADIAF QRYDMLHGIF RKQKTVSKSG KWLARLAVSC
260 270 280 290 300
LVLAILSFVG SRSIALWHTL KIEDQLQQQQ QETWQRYFPQ IKRTHNFRFY
310 320 330 340 350
FKQQLAQQYP EAVPLLYHLQ TLLLEHPELQ LMEANYSQKQ KSLTLKMSAK
360 370 380
SEANIDRFCE LTQSWLPMEK TEKDPVSGVW TVRNSGK
Length:387
Mass (Da):44,540
Last modified:December 1, 2000 - v2
Checksum:i3F123EEF75B9295A
GO

Sequence cautioni

The sequence AAA58130 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58130.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76358.2.
AP009048 Genomic DNA. Translation: BAE77958.1.
PIRiH65126.
RefSeqiNP_417792.2. NC_000913.3.
WP_001115238.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76358; AAC76358; b3333.
BAE77958; BAE77958; BAE77958.
GeneIDi947842.
KEGGiecj:JW5705.
eco:b3333.
PATRICi32122098. VBIEscCol129921_3426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58130.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76358.2.
AP009048 Genomic DNA. Translation: BAE77958.1.
PIRiH65126.
RefSeqiNP_417792.2. NC_000913.3.
WP_001115238.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45763.
SMRiP45763. Positions 5-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263437. 79 interactions.
STRINGi511145.b3333.

Proteomic databases

PaxDbiP45763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76358; AAC76358; b3333.
BAE77958; BAE77958; BAE77958.
GeneIDi947842.
KEGGiecj:JW5705.
eco:b3333.
PATRICi32122098. VBIEscCol129921_3426.

Organism-specific databases

EchoBASEiEB2732.
EcoGeneiEG12895. gspL.

Phylogenomic databases

eggNOGiENOG41063JA. Bacteria.
COG3297. LUCA.
HOGENOMiHOG000125386.
KOiK02461.
OMAiHEASGRW.

Enzyme and pathway databases

BioCyciEcoCyc:G7711-MONOMER.
ECOL316407:JW5705-MONOMER.
MetaCyc:G7711-MONOMER.

Miscellaneous databases

PROiP45763.

Family and domain databases

InterProiIPR024230. GspL_cyto_dom.
IPR025691. GspL_pp_dom.
IPR007812. T2SS_protein-L.
[Graphical view]
PfamiPF12693. GspL_C. 1 hit.
PF05134. T2SSL. 1 hit.
[Graphical view]
PIRSFiPIRSF015761. Protein_L. 1 hit.
TIGRFAMsiTIGR01709. typeII_sec_gspL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGSPL_ECOLI
AccessioniPrimary (citable) accession number: P45763
Secondary accession number(s): Q2M6Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 1, 2000
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.