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Protein

Putative type II secretion system protein K

Gene

gspK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7710-MONOMER
MetaCyc:G7710-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein K
Short name:
T2SS protein K
Alternative name(s):
Putative general secretion pathway protein K
Gene namesi
Name:gspK
Synonyms:yheJ
Ordered Locus Names:b3332, JW3294
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12894 gspK

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 327PeriplasmicSequence analysisAdd BLAST300

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150071 – 327Putative type II secretion system protein KAdd BLAST327

Proteomic databases

PaxDbiP45762
PRIDEiP45762

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263432, 343 interactors
STRINGi316385.ECDH10B_3507

Structurei

3D structure databases

ProteinModelPortaliP45762
SMRiP45762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105R04 Bacteria
COG3156 LUCA
HOGENOMiHOG000009791
InParanoidiP45762
KOiK02460
OMAiWFFADIQ

Family and domain databases

Gene3Di1.10.40.60, 2 hits
InterProiView protein in InterPro
IPR005628 GspK
IPR038072 GspK_central_sf
PANTHERiPTHR38831 PTHR38831, 1 hit
PfamiView protein in Pfam
PF03934 T2SSK, 1 hit
PIRSFiPIRSF002786 XcpX, 1 hit
SUPFAMiSSF158544 SSF158544, 2 hits

Sequencei

Sequence statusi: Complete.

P45762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNEQRGVAL LIVLMLLALM AALAADMTLS FHSQLQRTRQ VNHHLQRQYD
60 70 80 90 100
IELAEKLALA SLTQDVKDND RQTTLQQYWA QPQQLQLEDG NTVKWQLRDA
110 120 130 140 150
QHCFNLNALA KISDDPLASP DFPAQVFSAL LINAGIDRGN TDEIVQSIAD
160 170 180 190 200
YIDVDDSPRF HGAEDSFYQS QTPPRHSANQ MLFLTGELRQ IKGITENIYQ
210 220 230 240 250
RLIPYVCVLP TTELSINLNM LTENDIPLFR ALFLNNITDA DARVLLQKRP
260 270 280 290 300
REGWLTTDAF LYWAQQDFSG VKPLVAQVKR HLFPYSRYFT LSTESISDEQ
310 320
SQGWQSHIFF NRKQQSAQIY RRTLQLY
Length:327
Mass (Da):37,647
Last modified:November 1, 1995 - v1
Checksum:i6AFD6A3D2DBF2123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58129.1
U00096 Genomic DNA Translation: AAC76357.1
AP009048 Genomic DNA Translation: BAE77959.1
PIRiG65126
RefSeqiNP_417791.1, NC_000913.3
WP_001058522.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76357; AAC76357; b3332
BAE77959; BAE77959; BAE77959
GeneIDi947831
KEGGiecj:JW3294
eco:b3332
PATRICifig|1411691.4.peg.3399

Similar proteinsi

Entry informationi

Entry nameiGSPK_ECOLI
AccessioniPrimary (citable) accession number: P45762
Secondary accession number(s): Q2M6Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health