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Protein

Putative type II secretion system protein K

Gene

gspK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7710-MONOMER.
ECOL316407:JW3294-MONOMER.
MetaCyc:G7710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein K
Short name:
T2SS protein K
Alternative name(s):
Putative general secretion pathway protein K
Gene namesi
Name:gspK
Synonyms:yheJ
Ordered Locus Names:b3332, JW3294
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12894. gspK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 327PeriplasmicSequence analysisAdd BLAST300

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150071 – 327Putative type II secretion system protein KAdd BLAST327

Proteomic databases

PaxDbiP45762.
PRIDEiP45762.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263432. 343 interactors.
STRINGi511145.b3332.

Structurei

3D structure databases

ProteinModelPortaliP45762.
SMRiP45762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105R04. Bacteria.
COG3156. LUCA.
HOGENOMiHOG000009791.
InParanoidiP45762.
KOiK02460.
OMAiWFFADIQ.

Family and domain databases

InterProiIPR005628. GspK.
[Graphical view]
PfamiPF03934. T2SSK. 1 hit.
[Graphical view]
PIRSFiPIRSF002786. XcpX. 1 hit.

Sequencei

Sequence statusi: Complete.

P45762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNEQRGVAL LIVLMLLALM AALAADMTLS FHSQLQRTRQ VNHHLQRQYD
60 70 80 90 100
IELAEKLALA SLTQDVKDND RQTTLQQYWA QPQQLQLEDG NTVKWQLRDA
110 120 130 140 150
QHCFNLNALA KISDDPLASP DFPAQVFSAL LINAGIDRGN TDEIVQSIAD
160 170 180 190 200
YIDVDDSPRF HGAEDSFYQS QTPPRHSANQ MLFLTGELRQ IKGITENIYQ
210 220 230 240 250
RLIPYVCVLP TTELSINLNM LTENDIPLFR ALFLNNITDA DARVLLQKRP
260 270 280 290 300
REGWLTTDAF LYWAQQDFSG VKPLVAQVKR HLFPYSRYFT LSTESISDEQ
310 320
SQGWQSHIFF NRKQQSAQIY RRTLQLY
Length:327
Mass (Da):37,647
Last modified:November 1, 1995 - v1
Checksum:i6AFD6A3D2DBF2123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58129.1.
U00096 Genomic DNA. Translation: AAC76357.1.
AP009048 Genomic DNA. Translation: BAE77959.1.
PIRiG65126.
RefSeqiNP_417791.1. NC_000913.3.
WP_001058522.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76357; AAC76357; b3332.
BAE77959; BAE77959; BAE77959.
GeneIDi947831.
KEGGiecj:JW3294.
eco:b3332.
PATRICi32122096. VBIEscCol129921_3425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58129.1.
U00096 Genomic DNA. Translation: AAC76357.1.
AP009048 Genomic DNA. Translation: BAE77959.1.
PIRiG65126.
RefSeqiNP_417791.1. NC_000913.3.
WP_001058522.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45762.
SMRiP45762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263432. 343 interactors.
STRINGi511145.b3332.

Proteomic databases

PaxDbiP45762.
PRIDEiP45762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76357; AAC76357; b3332.
BAE77959; BAE77959; BAE77959.
GeneIDi947831.
KEGGiecj:JW3294.
eco:b3332.
PATRICi32122096. VBIEscCol129921_3425.

Organism-specific databases

EchoBASEiEB2731.
EcoGeneiEG12894. gspK.

Phylogenomic databases

eggNOGiENOG4105R04. Bacteria.
COG3156. LUCA.
HOGENOMiHOG000009791.
InParanoidiP45762.
KOiK02460.
OMAiWFFADIQ.

Enzyme and pathway databases

BioCyciEcoCyc:G7710-MONOMER.
ECOL316407:JW3294-MONOMER.
MetaCyc:G7710-MONOMER.

Miscellaneous databases

PROiP45762.

Family and domain databases

InterProiIPR005628. GspK.
[Graphical view]
PfamiPF03934. T2SSK. 1 hit.
[Graphical view]
PIRSFiPIRSF002786. XcpX. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGSPK_ECOLI
AccessioniPrimary (citable) accession number: P45762
Secondary accession number(s): Q2M6Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.