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Protein

Putative type II secretion system protein I

Gene

gspI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7708-MONOMER.
ECOL316407:JW5706-MONOMER.
MetaCyc:G7708-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein I
Short name:
T2SS protein I
Alternative name(s):
Putative general secretion pathway protein I
Gene namesi
Name:gspI
Synonyms:yheH
Ordered Locus Names:b3330, JW5706
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12892. gspI.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000242321 – 6By similarity6
ChainiPRO_00000242337 – 125Putative type II secretion system protein IAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N-methylmethioninePROSITE-ProRule annotation1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP45760.
PRIDEiP45760.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259596. 248 interactors.
STRINGi511145.b3330.

Structurei

3D structure databases

ProteinModelPortaliP45760.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP I family.Curated

Phylogenomic databases

eggNOGiCOG2165. LUCA.
HOGENOMiHOG000125364.
InParanoidiP45760.
KOiK02458.
PhylomeDBiP45760.

Family and domain databases

InterProiIPR012902. N_methyl_site.
IPR010052. T2SS_protein-I.
IPR003413. T2SS_protein-I_dom.
[Graphical view]
PfamiPF07963. N_methyl. 1 hit.
PF02501. T2SSI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01707. gspI. 1 hit.
TIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQSGMTLL EVLLAMSIFT AVALTLMSSM QGQRNAIERM RNETLALWIA
60 70 80 90 100
DNQLQSQDSF GEENTSSSGK ELINGEEWNW RSDIHSSKDG TLLERTITVT
110 120
LPSGQTTSLT RYQSIDNKSG QAQDD
Length:125
Mass (Da):13,901
Last modified:July 15, 1998 - v2
Checksum:i7BC1FB9B8192C2A4
GO

Sequence cautioni

The sequence AAA58127 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58127.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76355.2.
AP009048 Genomic DNA. Translation: BAE77961.1.
PIRiE65126.
RefSeqiNP_417789.4. NC_000913.3.
WP_001041743.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76355; AAC76355; b3330.
BAE77961; BAE77961; BAE77961.
GeneIDi947833.
KEGGiecj:JW5706.
eco:b3330.
PATRICi32122092. VBIEscCol129921_3423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58127.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76355.2.
AP009048 Genomic DNA. Translation: BAE77961.1.
PIRiE65126.
RefSeqiNP_417789.4. NC_000913.3.
WP_001041743.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45760.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259596. 248 interactors.
STRINGi511145.b3330.

Proteomic databases

PaxDbiP45760.
PRIDEiP45760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76355; AAC76355; b3330.
BAE77961; BAE77961; BAE77961.
GeneIDi947833.
KEGGiecj:JW5706.
eco:b3330.
PATRICi32122092. VBIEscCol129921_3423.

Organism-specific databases

EchoBASEiEB2729.
EcoGeneiEG12892. gspI.

Phylogenomic databases

eggNOGiCOG2165. LUCA.
HOGENOMiHOG000125364.
InParanoidiP45760.
KOiK02458.
PhylomeDBiP45760.

Enzyme and pathway databases

BioCyciEcoCyc:G7708-MONOMER.
ECOL316407:JW5706-MONOMER.
MetaCyc:G7708-MONOMER.

Miscellaneous databases

PROiP45760.

Family and domain databases

InterProiIPR012902. N_methyl_site.
IPR010052. T2SS_protein-I.
IPR003413. T2SS_protein-I_dom.
[Graphical view]
PfamiPF07963. N_methyl. 1 hit.
PF02501. T2SSI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01707. gspI. 1 hit.
TIGR02532. IV_pilin_GFxxxE. 1 hit.
PROSITEiPS00409. PROKAR_NTER_METHYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPI_ECOLI
AccessioniPrimary (citable) accession number: P45760
Secondary accession number(s): Q2M6Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.