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Protein

Putative type II secretion system protein E

Gene

gspE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi249 – 256ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7704-MONOMER
MetaCyc:G7704-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein E
Short name:
T2SS protein E
Alternative name(s):
Putative general secretion pathway protein E
Type II traffic warden ATPase
Gene namesi
Name:gspE
Synonyms:yheG
Ordered Locus Names:b3326, JW3288
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12891 gspE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002072841 – 493Putative type II secretion system protein EAdd BLAST493

Proteomic databases

PaxDbiP45759
PRIDEiP45759

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rplBP604222EBI-1132437,EBI-543515

Protein-protein interaction databases

BioGridi4261298, 330 interactors
IntActiP45759, 1 interactor
STRINGi316385.ECDH10B_3501

Structurei

3D structure databases

ProteinModelPortaliP45759
SMRiP45759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

eggNOGiENOG4107QHF Bacteria
COG2804 LUCA
HOGENOMiHOG000008427
InParanoidiP45759
KOiK02454
OMAiCAIRENQ
PhylomeDBiP45759

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR001482 T2SS/T4SS
IPR013369 T2SS_GspE
PfamiView protein in Pfam
PF00437 T2SSE, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR02533 type_II_gspE, 1 hit
PROSITEiView protein in PROSITE
PS00662 T2SP_E, 1 hit

Sequencei

Sequence statusi: Complete.

P45759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHSPYPAS WALAQRIGYL YSEGEIIYLA DTPFERLLDI QRQVGQCQTM
60 70 80 90 100
TSLSQADFEA RLEAVFHQNT GESQQIAQDI DQSVDLLSLS EEMPANEDLL
110 120 130 140 150
NEDSAAPVIR LINAILSEAI KETASDIHIE TYEKTMSIRF RIDGVLRTIL
160 170 180 190 200
QPNKKLAALL ISRIKVMARL DIAEKRIPQD GRISLRIGRR NIDVRVSTLP
210 220 230 240 250
SIYGERAVLR LLDKNSLQLS LNNLGMTAAD KQDLENLIQL PHGIILVTGP
260 270 280 290 300
TGSGKSTTLY AILSALNTPG RNILTVEDPV EYELEGIGQT QVNTRVDMSF
310 320 330 340 350
ARGLRAILRQ DPDVVMVGEI RDTETAQIAV QASLTGHLVL STLHTNSASG
360 370 380 390 400
AVTRLRDMGV ESFLLSSSLA GIIAQRLVRR LCPQCRQFTP VSPQQAQMFK
410 420 430 440 450
YHQLAVTTIG TPVGCPHCHQ SGYQGRMAIH EMMVVTPELR AAIHENVDEQ
460 470 480 490
ALERLVRQQH KALIKNGLQK VISGDTSWDE VMRVASATLE SEA
Length:493
Mass (Da):54,611
Last modified:November 1, 1995 - v1
Checksum:iA13C67C3D48596CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58123.1
U00096 Genomic DNA Translation: AAC76351.1
AP009048 Genomic DNA Translation: BAE77965.1
PIRiA65126
RefSeqiNP_417785.1, NC_000913.3
WP_001219894.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76351; AAC76351; b3326
BAE77965; BAE77965; BAE77965
GeneIDi947823
KEGGiecj:JW3288
eco:b3326
PATRICifig|1411691.4.peg.3405

Similar proteinsi

Entry informationi

Entry nameiGSPE_ECOLI
AccessioniPrimary (citable) accession number: P45759
Secondary accession number(s): Q2M6Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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