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Protein

Putative type II secretion system protein D

Gene

gspD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7703-MONOMER.
ECOL316407:JW5707-MONOMER.
MetaCyc:G7703-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein D
Short name:
T2SS protein D
Alternative name(s):
Putative general secretion pathway protein D
Gene namesi
Name:gspD
Synonyms:yheF
Ordered Locus Names:b3325, JW5707
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12890. gspD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001309924 – 650Putative type II secretion system protein DAdd BLAST627

Proteomic databases

PaxDbiP45758.
PRIDEiP45758.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261297. 268 interactors.
STRINGi511145.b3325.

Structurei

3D structure databases

ProteinModelPortaliP45758.
SMRiP45758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP D family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105GVR. Bacteria.
COG1450. LUCA.
HOGENOMiHOG000253751.
InParanoidiP45758.
KOiK02453.
OMAiQQAVQGN.
PhylomeDBiP45758.

Family and domain databases

InterProiIPR001775. GspD/PilQ.
IPR005644. NolW-like.
IPR004846. T2SS/T3SS.
IPR013356. T2SS_GspD.
IPR004845. T2SS_GspD_CS.
[Graphical view]
PfamiPF00263. Secretin. 1 hit.
PF03958. Secretin_N. 3 hits.
[Graphical view]
PRINTSiPR00811. BCTERIALGSPD.
TIGRFAMsiTIGR02517. type_II_gspD. 1 hit.
PROSITEiPS00875. T2SP_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLNKITCC LLAALLMPCA GHAENEQYGA NFNNADIRQF VEIVGQHLGK
60 70 80 90 100
TILIDPSVQG TISVRSNDTF SQQEYYQFFL SILDLYGYSV ITLDNGFLKV
110 120 130 140 150
VRSANVKTSP GMIADSSRPG VGDELVTRIV PLENVPARDL APLLRQMMDA
160 170 180 190 200
GSVGNVVHYE PSNVLILTGR ASTINKLIEV IKRVDVIGTE KQQIIHLEYA
210 220 230 240 250
SAEDLAEILN QLISESHGKS QMPALLSAKI VADKRTNSLI ISGPEKARQR
260 270 280 290 300
ITSLLKSLDV EESEEGNTRV YYLKYAKATN LVEVLTGVSE KLKDEKGNAR
310 320 330 340 350
KPSSSGAMDN VAITADEQTN SLVITADQSV QEKLATVIAR LDIRRAQVLV
360 370 380 390 400
EAIIVEVQDG NGLNLGVQWA NKNVGAQQFT NTGLPIFNAA QGVADYKKNG
410 420 430 440 450
GITSANPAWD MFSAYNGMAA GFFNGDWGVL LTALASNNKN DILATPSIVT
460 470 480 490 500
LDNKLASFNV GQDVPVLSGS QTTSGDNVFN TVERKTVGTK LKVTPQVNEG
510 520 530 540 550
DAVLLEIEQE VSSVDSSSNS TLGPTFNTRT IQNAVLVKTG ETVVLGGLLD
560 570 580 590 600
DFSKEQVSKV PLLGDIPLVG QLFRYTSTER AKRNLMVFIR PTIIRDDDVY
610 620 630 640 650
RSLSKEKYTR YRQEQQQRID GKSKALVGSE DLPVLDENTF NSHAPAPSSR
Length:650
Mass (Da):70,698
Last modified:July 11, 2001 - v2
Checksum:i973259A12A7237B2
GO

Sequence cautioni

The sequence AAA58122 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58122.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76350.2.
AP009048 Genomic DNA. Translation: BAE77966.1.
PIRiH65125.
RefSeqiNP_417784.4. NC_000913.3.
WP_001326512.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76350; AAC76350; b3325.
BAE77966; BAE77966; BAE77966.
GeneIDi947822.
KEGGiecj:JW5707.
eco:b3325.
PATRICi32122082. VBIEscCol129921_3418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58122.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76350.2.
AP009048 Genomic DNA. Translation: BAE77966.1.
PIRiH65125.
RefSeqiNP_417784.4. NC_000913.3.
WP_001326512.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45758.
SMRiP45758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261297. 268 interactors.
STRINGi511145.b3325.

Proteomic databases

PaxDbiP45758.
PRIDEiP45758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76350; AAC76350; b3325.
BAE77966; BAE77966; BAE77966.
GeneIDi947822.
KEGGiecj:JW5707.
eco:b3325.
PATRICi32122082. VBIEscCol129921_3418.

Organism-specific databases

EchoBASEiEB2727.
EcoGeneiEG12890. gspD.

Phylogenomic databases

eggNOGiENOG4105GVR. Bacteria.
COG1450. LUCA.
HOGENOMiHOG000253751.
InParanoidiP45758.
KOiK02453.
OMAiQQAVQGN.
PhylomeDBiP45758.

Enzyme and pathway databases

BioCyciEcoCyc:G7703-MONOMER.
ECOL316407:JW5707-MONOMER.
MetaCyc:G7703-MONOMER.

Miscellaneous databases

PROiP45758.

Family and domain databases

InterProiIPR001775. GspD/PilQ.
IPR005644. NolW-like.
IPR004846. T2SS/T3SS.
IPR013356. T2SS_GspD.
IPR004845. T2SS_GspD_CS.
[Graphical view]
PfamiPF00263. Secretin. 1 hit.
PF03958. Secretin_N. 3 hits.
[Graphical view]
PRINTSiPR00811. BCTERIALGSPD.
TIGRFAMsiTIGR02517. type_II_gspD. 1 hit.
PROSITEiPS00875. T2SP_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPD_ECOLI
AccessioniPrimary (citable) accession number: P45758
Secondary accession number(s): Q2M6Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 11, 2001
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.