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Protein

Putative type II secretion system protein C

Gene

gspC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7702-MONOMER.
ECOL316407:JW3286-MONOMER.
MetaCyc:G7702-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein C
Short name:
T2SS protein C
Alternative name(s):
Putative general secretion pathway protein C
Gene namesi
Name:gspC
Synonyms:yheE
Ordered Locus Names:b3324, JW3286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12889. gspC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 271PeriplasmicSequence analysisAdd BLAST233

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150001 – 271Putative type II secretion system protein CAdd BLAST271

Proteomic databases

PaxDbiP45757.
PRIDEiP45757.

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261296. 198 interactors.
STRINGi511145.b3324.

Structurei

3D structure databases

ProteinModelPortaliP45757.
SMRiP45757.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107KSE. Bacteria.
COG3031. LUCA.
HOGENOMiHOG000125342.
KOiK02452.
OMAiFAAICIC.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLRFPFHL ANHNKDAAIN ILIIFISIGS IIFNVNYFHT TIVKNGQIIN
60 70 80 90 100
QPTNAFQSDF SLAALWRNEN HAGVKDANPV AVNQETPKLS IALNGIVLTS
110 120 130 140 150
NDETSFVLIN EGSEQKRYSL NEALESAPGT FIRKINKTSV VFETHGHYEK
160 170 180 190 200
VTLHPGLPDI IKQPDSESQN VLADYIIATP IRDGEQIYGL RLNPRKGLNA
210 220 230 240 250
FTTSLLQPGD IALRINNLSL THPDEVSQAL SLLLTQQSAQ FTIRRNGVPR
260 270
LINVSVGELT GMNGLRHERT Q
Length:271
Mass (Da):30,038
Last modified:November 1, 1995 - v1
Checksum:i439E9EDCA50C5E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58121.1.
U00096 Genomic DNA. Translation: AAC76349.1.
AP009048 Genomic DNA. Translation: BAE77967.1.
PIRiG65125.
RefSeqiNP_417783.1. NC_000913.3.
WP_001142708.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76349; AAC76349; b3324.
BAE77967; BAE77967; BAE77967.
GeneIDi947824.
KEGGiecj:JW3286.
eco:b3324.
PATRICi32122080. VBIEscCol129921_3417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58121.1.
U00096 Genomic DNA. Translation: AAC76349.1.
AP009048 Genomic DNA. Translation: BAE77967.1.
PIRiG65125.
RefSeqiNP_417783.1. NC_000913.3.
WP_001142708.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP45757.
SMRiP45757.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261296. 198 interactors.
STRINGi511145.b3324.

Proteomic databases

PaxDbiP45757.
PRIDEiP45757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76349; AAC76349; b3324.
BAE77967; BAE77967; BAE77967.
GeneIDi947824.
KEGGiecj:JW3286.
eco:b3324.
PATRICi32122080. VBIEscCol129921_3417.

Organism-specific databases

EchoBASEiEB2726.
EcoGeneiEG12889. gspC.

Phylogenomic databases

eggNOGiENOG4107KSE. Bacteria.
COG3031. LUCA.
HOGENOMiHOG000125342.
KOiK02452.
OMAiFAAICIC.

Enzyme and pathway databases

BioCyciEcoCyc:G7702-MONOMER.
ECOL316407:JW3286-MONOMER.
MetaCyc:G7702-MONOMER.

Miscellaneous databases

PROiP45757.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001639. T2SS_protein-C.
IPR024961. T2SSC_N.
[Graphical view]
PfamiPF11356. T2SSC. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
TIGRFAMsiTIGR01713. typeII_sec_gspC. 1 hit.
PROSITEiPS01141. T2SP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSPC_ECOLI
AccessioniPrimary (citable) accession number: P45757
Secondary accession number(s): Q2M6Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.