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Protein

Putative type II secretion system protein C

Gene

gspC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.Curated

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7702-MONOMER
MetaCyc:G7702-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative type II secretion system protein C
Short name:
T2SS protein C
Alternative name(s):
Putative general secretion pathway protein C
Gene namesi
Name:gspC
Synonyms:yheE
Ordered Locus Names:b3324, JW3286
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12889 gspC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 271PeriplasmicSequence analysisAdd BLAST233

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150001 – 271Putative type II secretion system protein CAdd BLAST271

Proteomic databases

PaxDbiP45757
PRIDEiP45757

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261296, 198 interactors
STRINGi316385.ECDH10B_3499

Structurei

3D structure databases

ProteinModelPortaliP45757
SMRiP45757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP C family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107KSE Bacteria
COG3031 LUCA
HOGENOMiHOG000125342
KOiK02452
OMAiICCSTIA

Family and domain databases

InterProiView protein in InterPro
IPR036034 PDZ_sf
IPR001639 T2SS_protein-C
IPR024961 T2SSC_N
PfamiView protein in Pfam
PF11356 T2SSC, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
TIGRFAMsiTIGR01713 typeII_sec_gspC, 1 hit
PROSITEiView protein in PROSITE
PS01141 T2SP_C, 1 hit

Sequencei

Sequence statusi: Complete.

P45757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLRFPFHL ANHNKDAAIN ILIIFISIGS IIFNVNYFHT TIVKNGQIIN
60 70 80 90 100
QPTNAFQSDF SLAALWRNEN HAGVKDANPV AVNQETPKLS IALNGIVLTS
110 120 130 140 150
NDETSFVLIN EGSEQKRYSL NEALESAPGT FIRKINKTSV VFETHGHYEK
160 170 180 190 200
VTLHPGLPDI IKQPDSESQN VLADYIIATP IRDGEQIYGL RLNPRKGLNA
210 220 230 240 250
FTTSLLQPGD IALRINNLSL THPDEVSQAL SLLLTQQSAQ FTIRRNGVPR
260 270
LINVSVGELT GMNGLRHERT Q
Length:271
Mass (Da):30,038
Last modified:November 1, 1995 - v1
Checksum:i439E9EDCA50C5E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58121.1
U00096 Genomic DNA Translation: AAC76349.1
AP009048 Genomic DNA Translation: BAE77967.1
PIRiG65125
RefSeqiNP_417783.1, NC_000913.3
WP_001142708.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76349; AAC76349; b3324
BAE77967; BAE77967; BAE77967
GeneIDi947824
KEGGiecj:JW3286
eco:b3324
PATRICifig|1411691.4.peg.3407

Similar proteinsi

Entry informationi

Entry nameiGSPC_ECOLI
AccessioniPrimary (citable) accession number: P45757
Secondary accession number(s): Q2M6Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health