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Protein

Putative general secretion pathway protein A

Gene

gspA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a regulatory role under conditions of derepressed gsp gene expression.1 Publication

Miscellaneous

Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7701-MONOMER

Protein family/group databases

TCDBi9.B.42.1.3 the exeab (exeab) secretin assembly/export complex

Names & Taxonomyi

Protein namesi
Recommended name:
Putative general secretion pathway protein A
Gene namesi
Name:gspA
Synonyms:yheD
Ordered Locus Names:b3323, JW3285
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12888 gspA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002149941 – 489Putative general secretion pathway protein AAdd BLAST489

Proteomic databases

PaxDbiP45756
PRIDEiP45756

Expressioni

Inductioni

Silenced by the DNA-binding protein H-NS under standard growth conditions.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261295, 259 interactors
IntActiP45756, 1 interactor
STRINGi316385.ECDH10B_3498

Structurei

3D structure databases

ProteinModelPortaliP45756
SMRiP45756
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExeA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410899B Bacteria
ENOG41120C0 LUCA
HOGENOMiHOG000009790
InParanoidiP45756
KOiK02450
OMAiWFTRHFS

Family and domain databases

Gene3Di1.10.101.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PfamiView protein in Pfam
PF13401 AAA_22, 1 hit
PF01471 PG_binding_1, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P45756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRREVILS WLCEKRQTWR LCYLLGEAGS GKTWLAQQLQ KDKHRRVITL
60 70 80 90 100
SLVVSWQGKA AWIVTDDNAA EQGCRDSAWT RDEMAGQLLH ALHRTDSRCP
110 120 130 140 150
LIIIENAHLN HRRILDDLQR AISLIPDGQF LLIGRPDRKV ERDFKKQGIE
160 170 180 190 200
LVSIGRLTEH ELKASILEGQ NIDQPDLLLT ARVLKRIALL CRGDRRKLAL
210 220 230 240 250
AGETIRLLQQ AEQTSVFTAK QWRMIYRILG DNRPRKMQLA VVMSGTIIAL
260 270 280 290 300
TCGWLLLSSF TATLPVPAWL IPVTPVVKQD MTKDIAHVVM RDSEALSVLY
310 320 330 340 350
GVWGYEVPAD SAWCDQAVRA GLACKSGNAS LQTLVDQNLP WIASLKVGDK
360 370 380 390 400
KLPVVVVRVG EASVDVLVGQ QTWTLTHKWF ESVWTGDYLL LWKMSPEGES
410 420 430 440 450
TITRDSSEEE ILWLETMLNR ALHISTEPSA EWRPLLVEKI KQFQKSHHLK
460 470 480
TDGVVGFSTL VHLWQVAGES AYLYRDEANI SPETTVKGK
Length:489
Mass (Da):55,298
Last modified:November 1, 1995 - v1
Checksum:i7C7DDB238274E15C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58120.1
U00096 Genomic DNA Translation: AAC76348.1
AP009048 Genomic DNA Translation: BAE77968.1
PIRiF65125
RefSeqiNP_417782.1, NC_000913.3
WP_000107576.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76348; AAC76348; b3323
BAE77968; BAE77968; BAE77968
GeneIDi947825
KEGGiecj:JW3285
eco:b3323
PATRICifig|1411691.4.peg.3408

Similar proteinsi

Entry informationi

Entry nameiGSPA_ECOLI
AccessioniPrimary (citable) accession number: P45756
Secondary accession number(s): Q2M6Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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