Reviewed, UniProtKB/Swiss-Prot P45756 (GSPA_ECOLI)

Names and origin

Protein names

Recommended name:
    Probable general secretion pathway protein A

Gene names

Name:	gspA
Synonyms:	yheD
Ordered Locus Names:	b3323, JW3285

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in a general secretion pathway (GSP) for the export of proteins By similarity.
Sequence similarities	Belongs to the exeA family.

Ontologies

Keywords
Biological process	Transport
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
groL	P0A6F5	1	EBI-1132428,EBI-543750

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Probable general secretion pathway protein A		PRO_0000214994
Regions
	Nucleotide binding	26 – 33	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P45756-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7C7DDB238274E15C	FASTA	489	55,298
	10 20 30 40 50 60 MSTRREVILS WLCEKRQTWR LCYLLGEAGS GKTWLAQQLQ KDKHRRVITL SLVVSWQGKA 70 80 90 100 110 120 AWIVTDDNAA EQGCRDSAWT RDEMAGQLLH ALHRTDSRCP LIIIENAHLN HRRILDDLQR 130 140 150 160 170 180 AISLIPDGQF LLIGRPDRKV ERDFKKQGIE LVSIGRLTEH ELKASILEGQ NIDQPDLLLT 190 200 210 220 230 240 ARVLKRIALL CRGDRRKLAL AGETIRLLQQ AEQTSVFTAK QWRMIYRILG DNRPRKMQLA 250 260 270 280 290 300 VVMSGTIIAL TCGWLLLSSF TATLPVPAWL IPVTPVVKQD MTKDIAHVVM RDSEALSVLY 310 320 330 340 350 360 GVWGYEVPAD SAWCDQAVRA GLACKSGNAS LQTLVDQNLP WIASLKVGDK KLPVVVVRVG 370 380 390 400 410 420 EASVDVLVGQ QTWTLTHKWF ESVWTGDYLL LWKMSPEGES TITRDSSEEE ILWLETMLNR 430 440 450 460 470 480 ALHISTEPSA EWRPLLVEKI KQFQKSHHLK TDGVVGFSTL VHLWQVAGES AYLYRDEANI SPETTVKGK

References

[1]

"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.

[2]

"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18997 Genomic DNA. Translation: AAA58120.1. U00096 Genomic DNA. Translation: AAC76348.1. AP009048 Genomic DNA. Translation: BAE77968.1.
PIR	F65125.
RefSeq	AP_004467.1. NP_417782.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P45756. 1 interaction.
Genome annotation databases
GeneID	947825.
GenomeReviews	Gene locus JW3285 in contig AP009048_GR. Gene locus b3323 in contig U00096_GR.
KEGG	ecj:JW3285. eco:b3323.
Organism-specific databases
EchoBASE	EB2725.
EcoGene	EG12888. gspA.
CMR	Search...
Phylogenomic databases
HOGENOM	P45756.
OMA	P45756. VCKSGNA.
Enzyme and pathway databases
BioCyc	EcoCyc:G7701-MON.
Family and domain databases
InterPro	IPR002477. Peptidoglycan-bd-like. [Graphical view]
Gene3D	G3DSA:1.10.101.10. PGBD_1. 1 hit.
Pfam	PF01471. PG_binding_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSPA_ECOLI

Accession

Primary (citable) accession number: P45756
Secondary accession number(s): Q2M6Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)