UniProtKB - P45751 (HOFO_ECOLI)
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Protein
DNA utilization protein HofO
Gene
hofO
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the use of extracellular DNA as a nutrient.1 Publication
GO - Biological processi
- carbon utilization Source: EcoCyc
- DNA catabolic process Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:G7737-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA utilization protein HofO |
Gene namesi | Name:hofO Synonyms:yrfB Ordered Locus Names:b3393, JW3356 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG12923 hofO |
Subcellular locationi
- Cell inner membrane Curated; Single-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 37 | HelicalSequence analysisAdd BLAST | 18 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169538 | 1 – 146 | DNA utilization protein HofOAdd BLAST | 146 |
Proteomic databases
PaxDbi | P45751 |
PRIDEi | P45751 |
Interactioni
Protein-protein interaction databases
BioGridi | 42624846 interactors. |
DIPi | DIP-12919N |
IntActi | P45751 4 interactors. |
STRINGi | 316385.ECDH10B_3568 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105XPX Bacteria ENOG411265W LUCA |
HOGENOMi | HOG000125521 |
KOi | K12290 |
OMAi | WLARCGM |
i Sequence
Sequence statusi: Complete.
P45751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMFFDWWFA TSPRLRQLCW AFWLLMLVTL IFLSSTHHEE RDALIRLRAS
60 70 80 90 100
HHQQWAALYR LVDTAPFSEE KTLPFSPLDF QLSGAQLVSW HPSAQGGELA
110 120 130 140
LKTLWEAVPS AFTRLAERNV SVSRFSLSVE GDDLLFTLQL ETPHEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58190.1 U00096 Genomic DNA Translation: AAC76418.1 AP009048 Genomic DNA Translation: BAE77898.1 |
PIRi | D65134 |
RefSeqi | NP_417852.1, NC_000913.3 WP_001055759.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76418; AAC76418; b3393 BAE77898; BAE77898; BAE77898 |
GeneIDi | 947899 |
KEGGi | ecj:JW3356 eco:b3393 |
PATRICi | fig|1411691.4.peg.3337 |
Similar proteinsi
Entry informationi
Entry namei | HOFO_ECOLI | |
Accessioni | P45751Primary (citable) accession number: P45751 Secondary accession number(s): Q2M758 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |