hofO

Functionⁱ

Required for the use of extracellular DNA as a nutrient.1 Publication

GO - Biological processⁱ

carbon utilization
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 16707682

Complete GO annotation...

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G7737-MONOMER.

BioCycⁱ

EcoCyc:G7737-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA utilization protein HofO
Gene namesⁱ	Name:hofO Synonyms:yrfB Ordered Locus Names:b3393, JW3356
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12923. hofO.

EcoGeneⁱ

EG12923. hofO.

Subcellular locationⁱ

Cell inner membrane Curated; Single-pass membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	20 – 37	HelicalSequence analysisAdd BLAST		18

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000169538	1 – 146	DNA utilization protein HofOAdd BLAST		146

Proteomic databases

PaxDbⁱ	P45751.
PRIDEⁱ	P45751.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4262484. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-12919N.
IntActⁱ	P45751. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1287965.
STRINGⁱ	511145.b3393.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P45751.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105XPX. Bacteria. ENOG411265W. LUCA.
HOGENOMⁱ	HOG000125521.
KEGG Orthology (KO) More...KOⁱ	K12290.

Sequenceⁱ

Sequence statusⁱ: Complete.

P45751-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNMFFDWWFA TSPRLRQLCW AFWLLMLVTL IFLSSTHHEE RDALIRLRAS 
        60         70         80         90        100
HHQQWAALYR LVDTAPFSEE KTLPFSPLDF QLSGAQLVSW HPSAQGGELA 
       110        120        130        140 
LKTLWEAVPS AFTRLAERNV SVSRFSLSVE GDDLLFTLQL ETPHEG

Length:146

Mass (Da):16,846

Last modified:November 1, 1995 - v1

Checksum:ⁱ96548622C7D0374B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18997 Genomic DNA. Translation: AAA58190.1. U00096 Genomic DNA. Translation: AAC76418.1. AP009048 Genomic DNA. Translation: BAE77898.1.
PIRⁱ	D65134.
NCBI Reference Sequences More...RefSeqⁱ	NP_417852.1. NC_000913.3. WP_001055759.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAC76418; AAC76418; b3393. BAE77898; BAE77898; BAE77898.
GeneIDⁱ	947899.
KEGGⁱ	ecj:JW3356. eco:b3393.
PATRICⁱ	fig\|1411691.4.peg.3337.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18997 Genomic DNA. Translation: AAA58190.1. U00096 Genomic DNA. Translation: AAC76418.1. AP009048 Genomic DNA. Translation: BAE77898.1.
PIRⁱ	D65134.
NCBI Reference Sequences More...RefSeqⁱ	NP_417852.1. NC_000913.3. WP_001055759.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortalⁱ	P45751.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4262484. 6 interactors.
Database of interacting proteins More...DIPⁱ	DIP-12919N.
IntActⁱ	P45751. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1287965.
STRINGⁱ	511145.b3393.

Proteomic databases

PaxDbⁱ	P45751.
PRIDEⁱ	P45751.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76418; AAC76418; b3393. BAE77898; BAE77898; BAE77898.
GeneIDⁱ	947899.
KEGGⁱ	ecj:JW3356. eco:b3393.
PATRICⁱ	fig\|1411691.4.peg.3337.

Organism-specific databases

EchoBASEⁱ	EB2759.
EcoGeneⁱ	EG12923. hofO.

Phylogenomic databases

eggNOGⁱ	ENOG4105XPX. Bacteria. ENOG411265W. LUCA.
HOGENOMⁱ	HOG000125521.
KEGG Orthology (KO) More...KOⁱ	K12290.

Enzyme and pathway databases

BioCycⁱ	EcoCyc:G7737-MONOMER.

BioCycⁱ

EcoCyc:G7737-MONOMER.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P45751.

PROⁱ

PR:P45751.

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	HOFO_ECOLI
Accessionⁱ	P45751Primary (citable) accession number: P45751 Secondary accession number(s): Q2M758
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	June 7, 2017
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P45751 (HOFO_ECOLI)

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DNA utilization protein HofO

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ