Reviewed, UniProtKB/Swiss-Prot P45737 (CATA_BACFR)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:	katA
Synonyms:	katB
Ordered Locus Names:	BF1245

Organism

Bacteroides fragilis [Complete proteome] [HAMAP]

Taxonomic identifier

817 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. May be involved in aerotolerance of B.fragilis.
Catalytic activity	2 H(2)O(2) = O(2) + 2 H(2)O.
Cofactor	Heme group.
Subunit structure	Homodimer.
Induction	Up-regulated by oxygenation and stationary phase.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Catalase		PRO_0000084976
Sites
	Active site	54	1	By similarity
	Active site	127	1	By similarity
	Metal binding	337	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45737-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 4F28A24ED9B9A966	FASTA	486	55,906
	10 20 30 40 50 60 MENKKLTAAN GRPIADNQNS QTAGPRGPIM LQDPWLIEKL AHFDREVIPE RRMHAKGSGA 70 80 90 100 110 120 YGTFTVTHDI TKYTRAAIFS QVGKQTECFV RFSTVAGERG AADAERDIRG FAMKFYTEEG 130 140 150 160 170 180 NWDLVGNNTP VFFLRDPLKF PDLNHAVKRD PRNNMRSANN NWDFWTLLPE ALHQVTITMS 190 200 210 220 230 240 PRGIPASYRH MHGFGSHTYS FLNAENKRIW VKFHLKTMQG IKNLTDQEAE AIIAKDRESH 250 260 270 280 290 300 QRDLYESIER GDFPKWKFQI QLMTEEEADN YRINPFDLTK VWPHKDFPLQ DVGILELNRN 310 320 330 340 350 360 PENYFAEVEQ SAFNPMNIVE GIGFSPDKML QGRLFSYGDA QRYRLGVNSE QIPVNKPRCP 370 380 390 400 410 420 FHAFHRDGAM RVDGNYGSAK GYEPNSYGEW QDSPEKKEPP LKVHGDVFNY NEREYDDDYY 430 440 450 460 470 480 SQPGDLFRLM PADEQQLLFE NTARAMGDAE LFIKQRHVRN CYKADPAYGT GVAQALGIDL EEALKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Biochemical and genetic analyses of a catalase from the anaerobic bacterium Bacteroides fragilis." Rocha E.R., Smith C.J. J. Bacteriol. 177:3111-3119(1995) [PubMed: 7768808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-20. Strain: 638.
[2]	"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation." Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y. Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed: 15466707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: YCH46.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18676 Genomic DNA. Translation: AAC43384.1. AP006841 Genomic DNA. Translation: BAD47995.1.
PIR	A57262.
RefSeq	YP_098529.1.
3D structure databases
HSSP	HSSP built from PDB template 1M85 based on UniProtKB P42321.
ModBase	Search...
Genome annotation databases
GeneID	3082781.
GenomeReviews	Gene locus BF1245 in contig AP006841_GR.
KEGG	bfr:BF1245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P45737.
Enzyme and pathway databases
BioCyc	BFRA295405:BF1245-MON.
Family and domain databases
InterPro	IPR002226. Catalase. IPR011614. Catalase_N. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_BACFR

Accession

Primary (citable) accession number: P45737

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)