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Protein

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Gene

MAN1A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.By similarity

Cofactori

Ca2+By similarity

Enzyme regulationi

Inhibited by both 1-deoxymannojirimycin and kifunensine.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Proton donorBy similarity1
Metal bindingi449CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC:3.2.1.113By similarity)
Alternative name(s):
Man(9)-alpha-mannosidase
Mannosidase alpha class 1A member 1
Processing alpha-1,2-mannosidase IA
Short name:
Alpha-1,2-mannosidase IA
Gene namesi
Name:MAN1A1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 469LumenalSequence analysisAdd BLAST›469

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000210311‹1 – 469Mannosyl-oligosaccharide 1,2-alpha-mannosidase IAAdd BLAST›469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi292 ↔ 324By similarity
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP45701

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005793

Structurei

3D structure databases

ProteinModelPortaliP45701
SMRiP45701
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane

Phylogenomic databases

eggNOGiKOG2431 Eukaryota
ENOG410XP04 LUCA
HOGENOMiHOG000181988
HOVERGENiHBG052389
InParanoidiP45701

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

Sequencei

Sequence statusi: Fragment.

P45701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
REPADAAVRE KRAKIKEMME HAWNSYKRYA WGLNELKPIT KEGHSSSLFG
60 70 80 90 100
TIKGATIVDA LDTLFIMGME SEFQEAKSWI AENLDFNVNA EISVFEVNIR
110 120 130 140 150
FVGGLLSAYY LSGEEIFRKK AVELGIKLLP AFHTPSGIPW ALLNIKSGIG
160 170 180 190 200
RNWPWASGGS SILAEFGTLH LEFMHLSHLS GNPIFAEKVM NIRKVLNKLE
210 220 230 240 250
KPEGLYPNYL NPSSGQWGQH HVSIGGLGDS FYEYLLKAWL MSEKTDLEAK
260 270 280 290 300
KMYFDAVQAI ETHLIRKSSG GLTYIAEWKG GLLEHKMGHL TCFAGGMFAL
310 320 330 340 350
GADGAPEGRA QHYLELGAEI ARTCHESYNR TFMKLGPEAF RFDGGVEAIA
360 370 380 390 400
TRQNEKYYIL RPEVVETYMY MWRLTHDPKY RKWAWEAVEA LESHCRVNGG
410 420 430 440 450
YSGLRDVYFT HEKYDNVQQS FFLAETLKYL YLIFSDDDLL PLEHWIFNTE
460
AHLLPILPTD QKEVEVKVK
Length:469
Mass (Da):53,427
Last modified:November 1, 1995 - v1
Checksum:iA1B9128144FD0D39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04301 mRNA Translation: AAA17748.1
UniGeneiOcu.6237

Similar proteinsi

Entry informationi

Entry nameiMA1A1_RABIT
AccessioniPrimary (citable) accession number: P45701
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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