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P45696 (KAX35_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 3.5
Alternative name(s):
Kaliotoxin-2
Short name=KTX-2
Gene names
Name:KTX2
OrganismAndroctonus australis (Sahara scorpion)
Taxonomic identifier6858 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Protein attributes

Sequence length59 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and inhibits dendrotoxin sensitive voltage-dependent potassium channels and calcium-activated potassium channels.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Chain23 – 5937Potassium channel toxin alpha-KTx 3.5
PRO_0000035312

Regions

Region47 – 548Interaction with Ca(2+)-activated K(+) channels Potential

Amino acid modifications

Disulfide bond29 ↔ 49 By similarity
Disulfide bond35 ↔ 54 By similarity
Disulfide bond39 ↔ 56 By similarity

Sequences

Sequence LengthMass (Da)Tools
P45696 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: DD3225C5D270EB26

FASTA596,393
        10         20         30         40         50 
MKVFSAVLII LFVCSMIIGI NAVRIPVSCK HSGQCLKPCK DAGMRFGKCM NGKCDCTPK 

« Hide

References

[1]"The kaliotoxin family enlarged. Purification, characterization, and precursor nucleotide sequence of KTX2 from Androctonus australis venom."
Laraba-Djebari F., Legros C., Crest M., Ceard B., Romi R., Mansuelle P., Jacquet G., van Rietschoten J., Gola M., Rochat H.
J. Biol. Chem. 269:32835-32843(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-59.
Strain: Hector.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S74733 mRNA. Translation: AAB33535.1.
PIRA55807.

3D structure databases

ProteinModelPortalP45696.
SMRP45696. Positions 23-59.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX35_ANDAU
AccessionPrimary (citable) accession number: P45696
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries