Reviewed, UniProtKB/Swiss-Prot P45696 (KAX35_ANDAU)

Names and origin

Protein names

Recommended name:
    Potassium channel toxin alpha-KTx 3.5
Alternative name(s):
    Kaliotoxin-2
      Short name=KTX-2

Gene names

Name:

KTX2

Organism

Androctonus australis (Sahara scorpion)

Taxonomic identifier

6858 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus

Protein attributes

Sequence length	59 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds and inhibits dendrotoxin sensitive voltage-dependent potassium channels and calcium-activated potassium channels.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.1
	Chain	23 – 59	37	Potassium channel toxin alpha-KTx 3.5		PRO_0000035312
Regions
	Region	47 – 54	8	Interaction with Ca(2+)-activated K(+) channels Potential
Amino acid modifications
	Disulfide bond	29 ↔ 49		By similarity
	Disulfide bond	35 ↔ 54		By similarity
	Disulfide bond	39 ↔ 56		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45696-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: DD3225C5D270EB26	FASTA	59	6,393
	10 20 30 40 50 MKVFSAVLII LFVCSMIIGI NAVRIPVSCK HSGQCLKPCK DAGMRFGKCM NGKCDCTPK

References

[1]

"The kaliotoxin family enlarged. Purification, characterization, and precursor nucleotide sequence of KTX2 from Androctonus australis venom." Laraba-Djebari F., Legros C., Crest M., Ceard B., Romi R., Mansuelle P., Jacquet G., van Rietschoten J., Gola M., Rochat H. J. Biol. Chem. 269:32835-32843(1994) [PubMed: 7806508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-59. Strain: Hector. Tissue: Venom.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S74733 mRNA. Translation: AAB33535.1.
PIR	A55807.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX35_ANDAU

Accession

Primary (citable) accession number: P45696

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)