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Protein

Potassium channel toxin alpha-KTx 3.5

Gene

KTX2

Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds and inhibits dendrotoxin sensitive voltage-dependent potassium channels and calcium-activated potassium channels.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 3.5
Alternative name(s):
Kaliotoxin-2
Short name:
KTX-2
Gene namesi
Name:KTX2
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000003531223 – 59Potassium channel toxin alpha-KTx 3.5Add BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 49By similarity
Disulfide bondi35 ↔ 54By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP45696.
SMRiP45696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 54Interaction with Ca(2+)-activated K(+) channelsSequence analysis8

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
PfamiView protein in Pfam
PF00451. Toxin_2. 1 hit.
PRINTSiPR00286. CHARYBDTOXIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586. Scorpion_toxinS. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS01138. SCORP_SHORT_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45696-1 [UniParc]FASTAAdd to basket

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MKVFSAVLII LFVCSMIIGI NAVRIPVSCK HSGQCLKPCK DAGMRFGKCM

NGKCDCTPK
Length:59
Mass (Da):6,393
Last modified:November 1, 1995 - v1
Checksum:iDD3225C5D270EB26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74733 mRNA. Translation: AAB33535.1.
PIRiA55807.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKAX35_ANDAU
AccessioniPrimary (citable) accession number: P45696
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families