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Protein

Xylose isomerase

Gene

xylA

Organism
Thermotoga neapolitana
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Co2+Note: Binds 2 cobalt ions per subunit.

pH dependencei

Optimum pH is 7.1.

Temperature dependencei

Optimum temperature is above 95 degrees Celsius. Extremely thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1011
Active sitei104By similarity1
Metal bindingi232Cobalt 11
Metal bindingi268Cobalt 11
Metal bindingi268Cobalt 21
Metal bindingi271Cobalt 21
Metal bindingi296Cobalt 11
Metal bindingi307Cobalt 21
Metal bindingi309Cobalt 21
Metal bindingi339Cobalt 11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Cobalt, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiThermotoga neapolitana
Taxonomic identifieri2337 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001958141 – 444Xylose isomeraseAdd BLAST444

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi309803.CTN_0720.

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 26Combined sources4
Helixi38 – 42Combined sources5
Beta strandi45 – 47Combined sources3
Helixi48 – 51Combined sources4
Helixi68 – 70Combined sources3
Helixi75 – 93Combined sources19
Beta strandi97 – 101Combined sources5
Helixi102 – 105Combined sources4
Helixi112 – 132Combined sources21
Beta strandi136 – 141Combined sources6
Beta strandi145 – 147Combined sources3
Helixi148 – 150Combined sources3
Helixi160 – 179Combined sources20
Beta strandi183 – 187Combined sources5
Beta strandi192 – 195Combined sources4
Helixi202 – 222Combined sources21
Beta strandi227 – 231Combined sources5
Beta strandi237 – 244Combined sources8
Helixi247 – 256Combined sources10
Helixi260 – 262Combined sources3
Beta strandi263 – 268Combined sources6
Helixi269 – 274Combined sources6
Helixi279 – 288Combined sources10
Beta strandi292 – 296Combined sources5
Beta strandi304 – 306Combined sources3
Helixi315 – 328Combined sources14
Beta strandi336 – 338Combined sources3
Helixi349 – 376Combined sources28
Helixi378 – 386Combined sources9
Helixi388 – 390Combined sources3
Helixi393 – 400Combined sources8
Helixi405 – 412Combined sources8
Helixi425 – 441Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0EX-ray2.70A/D2-444[»]
ProteinModelPortaliP45687.
SMRiP45687.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45687.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P45687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFFPEIPK VQFEGKESTN PLAFKFYDPE EIIDGKPLKD HLKFSVAFWH
60 70 80 90 100
TFVNEGRDPF GDPTADRPWN RYTDPMDKAF ARVDALFEFC EKLNIEYFCF
110 120 130 140 150
HDRDIAPEGK TLRETNKILD KVVERIKERM KDSNVKLLWG TANLFSHPRY
160 170 180 190 200
MHGAATTCSA DVFAYAAAQV KKALEITKEL GGEGYVFWGG REGYETLLNT
210 220 230 240 250
DLGFELENLA RFLRMAVDYA KRIGFTGQFL IEPKPKEPTK HQYDFDVATA
260 270 280 290 300
YAFLKSHGLD EYFKFNIEAN HATLAGHTFQ HELRMARILG KLGSIDANQG
310 320 330 340 350
DLLLGWDTDQ FPTNVYDTTL AMYEVIKAGG FTKGGLNFDA KVRRASYKVE
360 370 380 390 400
DLFIGHIAGM DTFALGFKVA YKLVKDGVLD KFIEEKYRSF REGIGRDIVE
410 420 430 440
GKVDFEKLEE YIIDKETIEL PSGKQEYLES LINSYIVKTI LELR
Length:444
Mass (Da):50,893
Last modified:November 1, 1995 - v1
Checksum:i21F606C4D5F68D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38994 Genomic DNA. Translation: AAB06798.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38994 Genomic DNA. Translation: AAB06798.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0EX-ray2.70A/D2-444[»]
ProteinModelPortaliP45687.
SMRiP45687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309803.CTN_0720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.

Miscellaneous databases

EvolutionaryTraceiP45687.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_THENE
AccessioniPrimary (citable) accession number: P45687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.