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Protein

RNA polymerase sigma factor RpoS

Gene

rpoS

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi293 – 312H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • DNA-templated transcription, initiation Source: InterPro
  • negative regulation of secondary metabolite biosynthetic process Source: PseudoCAP
  • positive regulation of chemotaxis Source: PseudoCAP
  • positive regulation of single-species biofilm formation on inanimate substrate Source: PseudoCAP
  • regulation of cell motility Source: PseudoCAP
  • regulation of cellular response to heat Source: PseudoCAP
  • regulation of cellular response to oxidative stress Source: PseudoCAP
  • regulation of response to salt stress Source: PseudoCAP
  • regulation of transcription, DNA-templated Source: PseudoCAP

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3692-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor RpoSUniRule annotation
Alternative name(s):
Sigma SUniRule annotation
Sigma-38UniRule annotation
Gene namesi
Name:rpoSUniRule annotation
Ordered Locus Names:PA3622
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3622

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939751 – 334RNA polymerase sigma factor RpoSAdd BLAST334

Proteomic databases

PaxDbiP45684

Interactioni

Subunit structurei

Interacts with the RNA polymerase core enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA3622

Structurei

3D structure databases

ProteinModelPortaliP45684
SMRiP45684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 94Sigma-70 factor domain-1UniRule annotationAdd BLAST34
Regioni99 – 169Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni179 – 254Sigma-70 factor domain-3UniRule annotationAdd BLAST76
Regioni267 – 320Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 126Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
InParanoidiP45684
KOiK03087
OMAiITNRESQ
PhylomeDBiP45684

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00959 Sigma70_RpoS, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012761 RNA_pol_sigma_RpoS
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02394 rpoS_proteo, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P45684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKKEGPEF DHDDEVLLLE PGIMLDESSA DEQPSPRATP KATTSFSSKQ
60 70 80 90 100
HKHIDYTRAL DATQLYLNEI GFSPLLTPEE EVHFARLAQK GDPAGRKRMI
110 120 130 140 150
ESNLRLVVKI ARRYVNRGLS LLDLIEEGNL GLIRAVEKFD PERGFRFSTY
160 170 180 190 200
ATWWIRQTIE RAIMNQTRTI RLPIHVVKEL NVYLRAAREL THKLDHEPSP
210 220 230 240 250
EEIANLLEKP VAEVKRMLGL NERVTSVDVS LGPDSDKTLL DTLTDDRPTD
260 270 280 290 300
PCELLQDDDL SESIDQWLTE LTDKQREVVI RRFGLRGHES STLEEVGQEI
310 320 330
GLTRERVRQI QVEALKRLRE ILEKNGLSSD ALFQ
Length:334
Mass (Da):38,235
Last modified:November 1, 1995 - v1
Checksum:iB049427E5CBDC9DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26134 Genomic DNA Translation: BAA05131.1
AE004091 Genomic DNA Translation: AAG07010.1
PIRiS55064
RefSeqiNP_252312.1, NC_002516.2
WP_003113871.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07010; AAG07010; PA3622
GeneIDi880421
KEGGipae:PA3622
PATRICifig|208964.12.peg.3791

Similar proteinsi

Entry informationi

Entry nameiRPOS_PSEAE
AccessioniPrimary (citable) accession number: P45684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health