P45669 (TTX6_TITSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Toxin Ts6 Alternative name(s): P-Allerg-alpha* NaTx4.1 Tityustoxin VI Short name=Ts VI Short name=TsTX-VI Short name=TsTXVI Short name=TsVI Tityustoxin-6 Ts4
Organism	Tityus serrulatus (Brazilian scorpion)
Taxonomic identifier	6887 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not evoke the usual symptoms induced by the typical neurotoxins of this venom, but only a generalized allergic reaction. Induces a dose dependent release of the neurotransmitters glutamic acid and gamma aminobutyric acid from rat brain synaptosomes. Ref.2
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Allergenic properties	Causes an allergic reaction in mice.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ion channel inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 62	62	Toxin Ts6		PRO_0000066828
Amino acid modifications
	Modified residue	62	1	Cysteine amide Probable
	Disulfide bond	12 ↔ 62		By similarity
	Disulfide bond	16 ↔ 38		By similarity
	Disulfide bond	24 ↔ 43		By similarity
	Disulfide bond	28 ↔ 45		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45669 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EFF355CDB1594839	FASTA	62	6,717
	10 20 30 40 50 60 GREGYPADSK GCKITCFLTA AGYCNTECTL KKGSSGYCAW PACYCYGLPE SVKIWTSETN KC

References

[1]	"The complete amino acid sequence of toxin TsTX-VI isolated from the venom of the scorpion Tityus serrulatus." Marangoni S., Ghiso J., Sampaio S.V., Arantes E.C., Giglio J.R., Oliveira B., Frangione B. J. Protein Chem. 9:595-601(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.
[2]	"Isolation of toxin TsTX-VI from Tityus serrulatus scorpion venom. Effects on the release of neurotransmitters from synaptosomes." Sampaio S.V., Coutinho-Netto J., Arantes E.C., Marangoni S., Oliveira B., Giglio J.R. Biochem. Mol. Biol. Int. 39:729-740(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[3]	"Identification and phylogenetic analysis of Tityus pachyurus and Tityus obscurus novel putative Na+-channel scorpion toxins." Guerrero-Vargas J.A., Mourao C.B., Quintero-Hernandez V., Possani L.D., Schwartz E.F. PLoS ONE 7:E30478-E30478(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.

Cross-references

Sequence databases
PIR	A61484.
3D structure databases
ProteinModelPortal	P45669.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TTX6_TITSE

Accession

Primary (citable) accession number: P45669

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)