P45666 (SCX1_CENLL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Beta-toxin Cll1m Alternative name(s): Neurotoxin 1 Toxin II.8.4.3
Organism	Centruroides limpidus limpidus (Mexican scorpion)
Taxonomic identifier	29941 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides › Centruroides limpidus

Protein attributes

Sequence length	66 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 66	66	Beta-toxin Cll1m		PRO_0000066762
Amino acid modifications
	Modified residue	66	1	Threonine amide By similarity
	Disulfide bond	12 ↔ 65		By similarity
	Disulfide bond	16 ↔ 41		By similarity
	Disulfide bond	25 ↔ 46		By similarity
	Disulfide bond	29 ↔ 48		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P45666 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: CD853945D0A4B1C2	FASTA	66	7,550
	10 20 30 40 50 60 KEGYIVNLST GCKYECYKLG DNDYCLRECK QQYGKGAGGY CYAFGCWCTH LYEQAVVWPL PKKTCT

References

[1]	"Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch." Ramirez A.N., Martin B.M., Gurrola G.B., Possani L.D. Toxicon 32:479-490(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

3D structure databases
ProteinModelPortal	P45666.
SMR	P45666. Positions 1-66.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SCX1_CENLL

Accession

Primary (citable) accession number: P45666

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program