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P45660 (KA165_LEIQH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 16.5
Alternative name(s):
Lqh 15-1
Toxin 15-1
alpha-KTx 1.7
OrganismLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifier6884 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Protein attributes

Sequence length36 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Augments responses to direct muscle stimulation probably by blocking calcium-activated potassium channels.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3636Potassium channel toxin alpha-KTx 16.5
PRO_0000044893

Regions

Region26 – 338Interaction with Ca(2+)-activated K(+) channels Potential

Sites

Site271Basic residue of the functional dyad By similarity
Site361Aromatic residue of the functional dyad By similarity

Amino acid modifications

Disulfide bond7 ↔ 28 By similarity
Disulfide bond13 ↔ 33 By similarity
Disulfide bond17 ↔ 35 By similarity

Sequences

Sequence LengthMass (Da)Tools
P45660 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 11866427AA00C467

FASTA364,144
        10         20         30 
GLIDVRCYDS RQCWIACKKV TGSTQGKCQN KQCRCY 

« Hide

References

[1]"Neuromuscular effects of some potassium channel blocking toxins from the venom of the scorpion Leiurus quinquestriatus hebreus."
Marshall D.L., Vatanpour H., Harvey A.L., Boyot P., Pinkasfeld S., Doljansky Y., Bouet F., Menez A.
Toxicon 32:1433-1443(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP45660.
SMRP45660. Positions 1-36.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKA165_LEIQH
AccessionPrimary (citable) accession number: P45660
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries