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Protein

Glutamine synthetase

Gene

glnII

Organism
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.By similarity

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109MagnesiumBy similarity1
Metal bindingi111MagnesiumBy similarity1
Binding sitei167ATPBy similarity1
Metal bindingi172MagnesiumBy similarity1
Metal bindingi179MagnesiumBy similarity1
Binding sitei278L-glutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processNitrogen fixation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase1 Publication (EC:6.3.1.2By similarity)
Short name:
GS1 Publication
Alternative name(s):
Glutamate--ammonia ligaseCurated
Glutamine synthetase II1 Publication
Short name:
GSII1 Publication
Gene namesi
Name:glnII1 Publication
Encoded oniPlasmid pSymB (megaplasmid 2)0 Publication
OrganismiRhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri382 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532261 – 329Glutamine synthetaseAdd BLAST329

Interactioni

Subunit structurei

Homooctamer and homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP45626
SMRiP45626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.10.20.701 hit
InterProiView protein in InterPro
IPR008147 Gln_synt_b-grasp
IPR036651 Gln_synt_N
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR008146 Gln_synth_cat_dom
IPR027303 Gln_synth_gly_rich_site
IPR027302 Gln_synth_N_conserv_site
PfamiView protein in Pfam
PF00120 Gln-synt_C, 1 hit
PF03951 Gln-synt_N, 1 hit
SMARTiView protein in SMART
SM01230 Gln-synt_C, 1 hit
SUPFAMiSSF54368 SSF54368, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00180 GLNA_1, 1 hit
PS00181 GLNA_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

P45626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKYKLEYIW LDATRPYQTL RGKTQIKEFD AFPTLEQLPL WGFDGSSTLQ
60 70 80 90 100
AEGRTSDCVL KPVTVYPDPV RTNGALVMCE VMMPDAETPH ASNTRATVLD
110 120 130 140 150
DEGAWFGFEQ EYFFYKNGRP LGFPEQGYPA PQGPYYTGVG YKNVGDVARQ
160 170 180 190 200
IVEEHLDICL AAGINHEGIN AEVAKGQWEF QIFGKGSKKA ADEVCVARYL
210 220 230 240 250
LVRLTEKYGI DVEFHCKPLG DTDWNGSGMH ANFSTAYLRE VGGQDYFEAL
260 270 280 290 300
MAAFEKNLHD HINVYGPDNH LRLTGKHETA PWDKFSYGVA DRGASIRVPH
310 320
SFVNNAYPGY LEDRRANSQG DPYQMLLSS
Length:329
Mass (Da):36,966
Last modified:November 1, 1995 - v1
Checksum:iAF74BB020F7D637D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17523 Genomic DNA Translation: CAB37407.1

Similar proteinsi

Entry informationi

Entry nameiGLNA2_RHIML
AccessioniPrimary (citable) accession number: P45626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid