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P45621 (GSA_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:GSA1
Synonyms:GSA
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375

Cofactor

Pyridoxal phosphate.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375

Porphyrin-containing compound metabolism; chlorophyll biosynthesis. HAMAP-Rule MF_00375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00375

Subcellular location

Plastidchloroplast HAMAP-Rule MF_00375.

Tissue specificity

Strongly expressed in leaves of etiolated plantlets independently of light treatment and, to a much lesser extent, in leaves of mature plants.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Chloroplast Potential
Chain29 – 466438Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic HAMAP-Rule MF_00375
PRO_0000001260

Amino acid modifications

Modified residue3061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P45621 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5523012AE808DE72

FASTA46649,646
        10         20         30         40         50         60 
MAVSAITGAR LTLGMSLSSS TRSRTVAMAV SIDPKTDNKL TLTKSEEAFA AAKELMPGGV 

        70         80         90        100        110        120 
NSPVRAFKSV GGQPIVIDSV KGSRMWDIDG NEYIDYVGSW GPAIIGHADD QVLAALGETM 

       130        140        150        160        170        180 
KKGTSFGAPC LLENTLAELV IDAVPSIEMV RFVNSGTEAC MGALRLARAY TGREKIIKFE 

       190        200        210        220        230        240 
GCYHGHADPF LVKAGSGVAT LGLPDSPGVP KAATFETLTA PYNDTEAIEK LFEANKGEIA 

       250        260        270        280        290        300 
AVFLEPVVGN AGFIVPKPDF HSFLRKITKE NNTLLVFDEV MTGFRLSYGG AQEYFGITPD 

       310        320        330        340        350        360 
ITTLGKIIGG GLPVGAYGGR RDIMEKVAPA GPMYQAGTLS GNPLAMTAGI ETLQRIKEPG 

       370        380        390        400        410        420 
TYEYLDKITG ELVEGIIEAG KRAGHAICGG HIRGMFGFFF TEGPVYNFAD AKKSDTAKFA 

       430        440        450        460 
RFFWGMLAEG VYLAPSQFEA GFTSLAHTSD DIKKTIAAAE KVFREI 

« Hide

References

[1]"Expression of the soybean (Glycine max) glutamate 1-semialdehyde aminotransferase gene in symbiotic root nodules."
Sangwan I., O'Brian M.R.
Plant Physiol. 102:829-834(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Root nodule.
[2]"gsa1 is a universal tetrapyrrole synthesis gene in soybean and is regulated by a GAGA element."
Frustaci J.M., Sangwan I., O'Brian M.R.
J. Biol. Chem. 270:7387-7393(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Essex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12453 mRNA. Translation: AAA33968.1.
U20260 Genomic DNA. Translation: AAC48996.1.
PIRJQ2263.
RefSeqNP_001238043.1. NM_001251114.1.
UniGeneGma.1779.

3D structure databases

ProteinModelPortalP45621.
SMRP45621. Positions 44-462.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP45621.
ProMEXP45621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsGLYMA06G00510.1; GLYMA06G00510.1; GLYMA06G00510.
GeneID547795.
KEGGgmx:547795.

Phylogenomic databases

KOK01845.

Enzyme and pathway databases

UniPathwayUPA00251; UER00317.
UPA00668.

Gene expression databases

GenevestigatorP45621.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_SOYBN
AccessionPrimary (citable) accession number: P45621
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways