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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene

GSA1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.

Cofactori

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (100819951), Glutamyl-tRNA reductase (gtr1), Glutamyl-tRNA reductase (100810957), Glutamyl-tRNA reductase (100815985), Glutamyl-tRNA reductase (100777511), Glutamyl-tRNA reductase (100776057), Glutamyl-tRNA reductase (100782247)
  2. Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Pathwayi: chlorophyll biosynthesis

This protein is involved in the pathway chlorophyll biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway chlorophyll biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processChlorophyll biosynthesis, Porphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317
UPA00668

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:GSA1
Synonyms:GSA
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28ChloroplastSequence analysisAdd BLAST28
ChainiPRO_000000126029 – 466Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei306N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiP45621
ProMEXiP45621

Expressioni

Tissue specificityi

Strongly expressed in leaves of etiolated plantlets independently of light treatment and, to a much lesser extent, in leaves of mature plants.

Gene expression databases

GenevisibleiP45621 GM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3847.GLYMA06G00510.1

Structurei

3D structure databases

ProteinModelPortaliP45621
SMRiP45621
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IPFV Eukaryota
COG0001 LUCA
InParanoidiP45621
KOiK01845
OMAiVIAEACP
OrthoDBiEOG093608WJ

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSAITGAR LTLGMSLSSS TRSRTVAMAV SIDPKTDNKL TLTKSEEAFA
60 70 80 90 100
AAKELMPGGV NSPVRAFKSV GGQPIVIDSV KGSRMWDIDG NEYIDYVGSW
110 120 130 140 150
GPAIIGHADD QVLAALGETM KKGTSFGAPC LLENTLAELV IDAVPSIEMV
160 170 180 190 200
RFVNSGTEAC MGALRLARAY TGREKIIKFE GCYHGHADPF LVKAGSGVAT
210 220 230 240 250
LGLPDSPGVP KAATFETLTA PYNDTEAIEK LFEANKGEIA AVFLEPVVGN
260 270 280 290 300
AGFIVPKPDF HSFLRKITKE NNTLLVFDEV MTGFRLSYGG AQEYFGITPD
310 320 330 340 350
ITTLGKIIGG GLPVGAYGGR RDIMEKVAPA GPMYQAGTLS GNPLAMTAGI
360 370 380 390 400
ETLQRIKEPG TYEYLDKITG ELVEGIIEAG KRAGHAICGG HIRGMFGFFF
410 420 430 440 450
TEGPVYNFAD AKKSDTAKFA RFFWGMLAEG VYLAPSQFEA GFTSLAHTSD
460
DIKKTIAAAE KVFREI
Length:466
Mass (Da):49,646
Last modified:November 1, 1995 - v1
Checksum:i5523012AE808DE72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12453 mRNA Translation: AAA33968.1
U20260 Genomic DNA Translation: AAC48996.1
PIRiJQ2263
RefSeqiNP_001238043.1, NM_001251114.1
UniGeneiGma.1779

Genome annotation databases

EnsemblPlantsiKRH51376; KRH51376; GLYMA_06G002900
GeneIDi547795
GrameneiKRH51376; KRH51376; GLYMA_06G002900
KEGGigmx:547795

Similar proteinsi

Entry informationi

Entry nameiGSA_SOYBN
AccessioniPrimary (citable) accession number: P45621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health