Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cofilin-2

Gene

Cfl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.3 Publications

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

  • actin filament depolymerization Source: UniProtKB
  • actin filament fragmentation Source: UniProtKB
  • actin filament organization Source: MGI
  • muscle cell cellular homeostasis Source: MGI
  • positive regulation of actin filament depolymerization Source: MGI
  • sarcomere organization Source: MGI
  • skeletal muscle tissue development Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin-2
Alternative name(s):
Cofilin, muscle isoform
Gene namesi
Name:Cfl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:101763. Cfl2.

Subcellular locationi

  • Nucleus matrix
  • Cytoplasmcytoskeleton

  • Note: Colocalizes with CSPR3 in the Z line of sarcomeres.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149082 – 166Cofilin-2Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei6PhosphothreonineCombined sources1
Modified residuei19N6-acetyllysineBy similarity1

Post-translational modificationi

The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP45591.
PaxDbiP45591.
PeptideAtlasiP45591.
PRIDEiP45591.

2D gel databases

REPRODUCTION-2DPAGEP45591.

PTM databases

iPTMnetiP45591.
PhosphoSitePlusiP45591.
SwissPalmiP45591.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000062929.
CleanExiMM_CFL2.
ExpressionAtlasiP45591. baseline and differential.
GenevisibleiP45591. MM.

Interactioni

Subunit structurei

Interacts with CSRP3; possibly two molecules of CFL2 can interact with one molecule if CSRP3.By similarity

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

Protein-protein interaction databases

BioGridi198685. 1 interactor.
IntActiP45591. 6 interactors.
MINTiMINT-1869247.
STRINGi10090.ENSMUSP00000077262.

Structurei

3D structure databases

ProteinModelPortaliP45591.
SMRiP45591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated
Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiP45591.
KOiK05765.
OMAiGLYDATY.
OrthoDBiEOG091G0PWC.
PhylomeDBiP45591.
TreeFamiTF328601.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE
60 70 80 90 100
EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV
110 120 130 140 150
FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG
160
EKLGGSVVVS LEGKPL
Length:166
Mass (Da):18,710
Last modified:November 1, 1995 - v1
Checksum:i48B6D7E5AE9FE1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29468 mRNA. Translation: AAA37433.1.
BC007138 mRNA. Translation: AAH07138.1.
CCDSiCCDS36448.1.
PIRiA53812.
RefSeqiNP_031714.1. NM_007688.2.
UniGeneiMm.276826.

Genome annotation databases

EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929.
GeneIDi12632.
KEGGimmu:12632.
UCSCiuc007nnx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29468 mRNA. Translation: AAA37433.1.
BC007138 mRNA. Translation: AAH07138.1.
CCDSiCCDS36448.1.
PIRiA53812.
RefSeqiNP_031714.1. NM_007688.2.
UniGeneiMm.276826.

3D structure databases

ProteinModelPortaliP45591.
SMRiP45591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198685. 1 interactor.
IntActiP45591. 6 interactors.
MINTiMINT-1869247.
STRINGi10090.ENSMUSP00000077262.

PTM databases

iPTMnetiP45591.
PhosphoSitePlusiP45591.
SwissPalmiP45591.

2D gel databases

REPRODUCTION-2DPAGEP45591.

Proteomic databases

EPDiP45591.
PaxDbiP45591.
PeptideAtlasiP45591.
PRIDEiP45591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929.
GeneIDi12632.
KEGGimmu:12632.
UCSCiuc007nnx.1. mouse.

Organism-specific databases

CTDi1073.
MGIiMGI:101763. Cfl2.

Phylogenomic databases

eggNOGiKOG1735. Eukaryota.
ENOG41122P5. LUCA.
GeneTreeiENSGT00440000033289.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiP45591.
KOiK05765.
OMAiGLYDATY.
OrthoDBiEOG091G0PWC.
PhylomeDBiP45591.
TreeFamiTF328601.

Miscellaneous databases

ChiTaRSiCfl2. mouse.
PROiP45591.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062929.
CleanExiMM_CFL2.
ExpressionAtlasiP45591. baseline and differential.
GenevisibleiP45591. MM.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOF2_MOUSE
AccessioniPrimary (citable) accession number: P45591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.