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P45591

- COF2_MOUSE

UniProt

P45591 - COF2_MOUSE

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Protein

Cofilin-2

Gene

Cfl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

GO - Biological processi

  1. actin filament depolymerization Source: InterPro
  2. actin filament organization Source: MGI
  3. muscle cell cellular homeostasis Source: MGI
  4. positive regulation of actin filament depolymerization Source: Ensembl
  5. regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
  6. sarcomere organization Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin-2
Alternative name(s):
Cofilin, muscle isoform
Gene namesi
Name:Cfl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:101763. Cfl2.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: InterPro
  2. extracellular space Source: Ensembl
  3. I band Source: Ensembl
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 166165Cofilin-2PRO_0000214908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei3 – 31Phosphoserine1 Publication
Modified residuei6 – 61Phosphothreonine1 Publication

Post-translational modificationi

The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP45591.
PaxDbiP45591.
PRIDEiP45591.

2D gel databases

REPRODUCTION-2DPAGEP45591.

PTM databases

PhosphoSiteiP45591.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle.

Gene expression databases

BgeeiP45591.
CleanExiMM_CFL2.
ExpressionAtlasiP45591. baseline and differential.
GenevestigatoriP45591.

Interactioni

Protein-protein interaction databases

BioGridi198685. 1 interaction.
IntActiP45591. 4 interactions.
MINTiMINT-1869247.
STRINGi10090.ENSMUSP00000077262.

Structurei

3D structure databases

ProteinModelPortaliP45591.
SMRiP45591. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 153150ADF-HPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 345Nuclear localization signalSequence Analysis

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated
Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303866.
HOGENOMiHOG000039697.
HOVERGENiHBG000381.
InParanoidiP45591.
KOiK05765.
OMAiCFVKLLP.
OrthoDBiEOG7353Z9.
PhylomeDBiP45591.
TreeFamiTF328601.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45591 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE
60 70 80 90 100
EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV
110 120 130 140 150
FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG
160
EKLGGSVVVS LEGKPL
Length:166
Mass (Da):18,710
Last modified:November 1, 1995 - v1
Checksum:i48B6D7E5AE9FE1CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29468 mRNA. Translation: AAA37433.1.
BC007138 mRNA. Translation: AAH07138.1.
CCDSiCCDS36448.1.
PIRiA53812.
RefSeqiNP_031714.1. NM_007688.2.
UniGeneiMm.276826.

Genome annotation databases

EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929.
GeneIDi12632.
KEGGimmu:12632.
UCSCiuc007nnx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L29468 mRNA. Translation: AAA37433.1 .
BC007138 mRNA. Translation: AAH07138.1 .
CCDSi CCDS36448.1.
PIRi A53812.
RefSeqi NP_031714.1. NM_007688.2.
UniGenei Mm.276826.

3D structure databases

ProteinModelPortali P45591.
SMRi P45591. Positions 1-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198685. 1 interaction.
IntActi P45591. 4 interactions.
MINTi MINT-1869247.
STRINGi 10090.ENSMUSP00000077262.

PTM databases

PhosphoSitei P45591.

2D gel databases

REPRODUCTION-2DPAGE P45591.

Proteomic databases

MaxQBi P45591.
PaxDbi P45591.
PRIDEi P45591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078124 ; ENSMUSP00000077262 ; ENSMUSG00000062929 .
GeneIDi 12632.
KEGGi mmu:12632.
UCSCi uc007nnx.1. mouse.

Organism-specific databases

CTDi 1073.
MGIi MGI:101763. Cfl2.

Phylogenomic databases

eggNOGi NOG303866.
HOGENOMi HOG000039697.
HOVERGENi HBG000381.
InParanoidi P45591.
KOi K05765.
OMAi CFVKLLP.
OrthoDBi EOG7353Z9.
PhylomeDBi P45591.
TreeFami TF328601.

Miscellaneous databases

ChiTaRSi CFL2. mouse.
NextBioi 281820.
PROi P45591.
SOURCEi Search...

Gene expression databases

Bgeei P45591.
CleanExi MM_CFL2.
ExpressionAtlasi P45591. baseline and differential.
Genevestigatori P45591.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
[Graphical view ]
PANTHERi PTHR11913. PTHR11913. 1 hit.
Pfami PF00241. Cofilin_ADF. 1 hit.
[Graphical view ]
PRINTSi PR00006. COFILIN.
SMARTi SM00102. ADF. 1 hit.
[Graphical view ]
PROSITEi PS51263. ADF_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle."
    Ono S., Minami N., Abe H., Obinata T.
    J. Biol. Chem. 269:15280-15286(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
    Tissue: Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND THR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCOF2_MOUSE
AccessioniPrimary (citable) accession number: P45591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3