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P45591

- COF2_MOUSE

UniProt

P45591 - COF2_MOUSE

Protein

Cofilin-2

Gene

Cfl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

    GO - Biological processi

    1. actin filament depolymerization Source: InterPro
    2. actin filament organization Source: MGI
    3. muscle cell cellular homeostasis Source: MGI
    4. regulation of dendritic spine morphogenesis Source: ParkinsonsUK-UCL
    5. sarcomere organization Source: MGI

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cofilin-2
    Alternative name(s):
    Cofilin, muscle isoform
    Gene namesi
    Name:Cfl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:101763. Cfl2.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: InterPro
    2. cytoplasm Source: UniProtKB-KW
    3. nuclear matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 166165Cofilin-2PRO_0000214908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei3 – 31Phosphoserine1 Publication
    Modified residuei6 – 61Phosphothreonine1 Publication

    Post-translational modificationi

    The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP45591.
    PaxDbiP45591.
    PRIDEiP45591.

    2D gel databases

    REPRODUCTION-2DPAGEP45591.

    PTM databases

    PhosphoSiteiP45591.

    Expressioni

    Tissue specificityi

    Predominantly expressed in skeletal muscle.

    Gene expression databases

    ArrayExpressiP45591.
    BgeeiP45591.
    CleanExiMM_CFL2.
    GenevestigatoriP45591.

    Interactioni

    Protein-protein interaction databases

    BioGridi198685. 1 interaction.
    IntActiP45591. 4 interactions.
    MINTiMINT-1869247.
    STRINGi10090.ENSMUSP00000077262.

    Structurei

    3D structure databases

    ProteinModelPortaliP45591.
    SMRiP45591. Positions 1-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 153150ADF-HPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 345Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Belongs to the actin-binding proteins ADF family.Curated
    Contains 1 ADF-H domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303866.
    HOGENOMiHOG000039697.
    HOVERGENiHBG000381.
    InParanoidiP45591.
    KOiK05765.
    OMAiCFVKLLP.
    OrthoDBiEOG7353Z9.
    PhylomeDBiP45591.
    TreeFamiTF328601.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR017904. ADF/Cofilin/Destrin.
    [Graphical view]
    PANTHERiPTHR11913. PTHR11913. 1 hit.
    PfamiPF00241. Cofilin_ADF. 1 hit.
    [Graphical view]
    PRINTSiPR00006. COFILIN.
    SMARTiSM00102. ADF. 1 hit.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P45591-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE    50
    EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV 100
    FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG 150
    EKLGGSVVVS LEGKPL 166
    Length:166
    Mass (Da):18,710
    Last modified:November 1, 1995 - v1
    Checksum:i48B6D7E5AE9FE1CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29468 mRNA. Translation: AAA37433.1.
    BC007138 mRNA. Translation: AAH07138.1.
    CCDSiCCDS36448.1.
    PIRiA53812.
    RefSeqiNP_031714.1. NM_007688.2.
    UniGeneiMm.276826.

    Genome annotation databases

    EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929.
    GeneIDi12632.
    KEGGimmu:12632.
    UCSCiuc007nnx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L29468 mRNA. Translation: AAA37433.1 .
    BC007138 mRNA. Translation: AAH07138.1 .
    CCDSi CCDS36448.1.
    PIRi A53812.
    RefSeqi NP_031714.1. NM_007688.2.
    UniGenei Mm.276826.

    3D structure databases

    ProteinModelPortali P45591.
    SMRi P45591. Positions 1-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198685. 1 interaction.
    IntActi P45591. 4 interactions.
    MINTi MINT-1869247.
    STRINGi 10090.ENSMUSP00000077262.

    PTM databases

    PhosphoSitei P45591.

    2D gel databases

    REPRODUCTION-2DPAGE P45591.

    Proteomic databases

    MaxQBi P45591.
    PaxDbi P45591.
    PRIDEi P45591.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078124 ; ENSMUSP00000077262 ; ENSMUSG00000062929 .
    GeneIDi 12632.
    KEGGi mmu:12632.
    UCSCi uc007nnx.1. mouse.

    Organism-specific databases

    CTDi 1073.
    MGIi MGI:101763. Cfl2.

    Phylogenomic databases

    eggNOGi NOG303866.
    HOGENOMi HOG000039697.
    HOVERGENi HBG000381.
    InParanoidi P45591.
    KOi K05765.
    OMAi CFVKLLP.
    OrthoDBi EOG7353Z9.
    PhylomeDBi P45591.
    TreeFami TF328601.

    Miscellaneous databases

    ChiTaRSi CFL2. mouse.
    NextBioi 281820.
    PROi P45591.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P45591.
    Bgeei P45591.
    CleanExi MM_CFL2.
    Genevestigatori P45591.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR017904. ADF/Cofilin/Destrin.
    [Graphical view ]
    PANTHERi PTHR11913. PTHR11913. 1 hit.
    Pfami PF00241. Cofilin_ADF. 1 hit.
    [Graphical view ]
    PRINTSi PR00006. COFILIN.
    SMARTi SM00102. ADF. 1 hit.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle."
      Ono S., Minami N., Abe H., Obinata T.
      J. Biol. Chem. 269:15280-15286(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
      Tissue: Skeletal muscle.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND THR-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCOF2_MOUSE
    AccessioniPrimary (citable) accession number: P45591
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3